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New application of traditional Chinese medicine fennel

A technology of fennel and traditional Chinese medicine, applied in the field of new application of traditional Chinese medicine fennel, can solve problems such as low efficiency, inability to effectively overcome the natural barrier function of the intestinal tract, and lack of practical value

Active Publication Date: 2014-04-02
SHANGHAI UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Although the stability of protein drugs has been improved, it still cannot effectively overcome the natural barrier function of the intestinal tract. The absorption efficiency of protein drugs into the blood is very low, and the bioavailability usually does not exceed 1%. Sodium alginate drug-loaded microspheres Use alone still lacks practical value

Method used

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  • New application of traditional Chinese medicine fennel
  • New application of traditional Chinese medicine fennel

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0017] Example 1: Preparation of Fennel Intestinal Absorption Promoter Decoction: The traditional Chinese medicine Fennel is decocted according to the conventional method to obtain a decoction of 0.3g / ml (dry weight / medicine solution), and the dose for intragastric administration is 0.5ml decoction / piece mice.

Embodiment 2

[0018] Example 2: Preparation of lysozyme sodium alginate microspheres: prepared by W / O emulsification-ion cross-linking method according to literature reference. The main preparation parameters are: sodium alginate concentration 5% (W / V), lysozyme concentration 1% (W / V), fructose concentration 2% (W / V). The performance of drug-loaded microspheres: spherical, smooth and round surface, less adhesion, no damage, good dispersion and stability, average particle size (9.45±3.1) μm, encapsulation rate 57.6%, drug loading capacity It was 7.2%, and the enzyme activity was 76.1% of the initial lysozyme activity.

Embodiment 3

[0019] Example 3: Oral administration and dosage: Fennel decoction and drug-loaded sodium alginate microspheres were administered to mice at the same time, once a day, and the dose of fennel decoction was 0.5 ml / mouse. The dose of drug-loaded sodium alginate microspheres was 14mg / mouse.

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Abstract

The invention relates to a new application of traditional Chinese medicine fennel. Fennel can promote intestinal absorption of lysozyme protein in the orally-taken sodium alginate microspheres so as to increase the lysozyme blood concentration and remarkably improve the bioavailability of lysozyme.

Description

technical field [0001] The invention relates to a new application of the traditional Chinese medicine fennel, in particular to the application of the traditional Chinese medicine fennel as an intestinal absorption promoter in improving the intestinal absorption efficiency of oral lysozyme. Background technique [0002] Lysozyme (Lysozyme) is a protein-based biological enzyme with antibacterial, antiviral, immune regulation, hemostasis, swelling, and accelerated tissue repair functions. It is an important non-specific immune factor and has a wide range of applications in the field of medicine Applications. [0003] The existing oral lysozyme drugs are mainly buccal tablets, powders and enteric-coated capsules, and their drug targets are mainly directly acting on pathogenic bacteria in the gastrointestinal tract, or as in vitro drugs, and the efficiency of in vivo absorption into the blood is very low. Very limited use. Intravenous injection can effectively increase the b...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K36/23A61K38/47A61P37/02A61P31/04A61P31/12A61P43/00
Inventor 陈宇光何佳郭敏苏洁戴小峰
Owner SHANGHAI UNIV