Universal and efficient photonic crystal microchip for detecting multiple substrates

A photonic crystal and microchip technology, used in fluorescence/phosphorescence, material excitation analysis, etc., can solve the problems of reducing detection limit and increasing luminescence intensity, and achieves high detection density, simple process, excellent environmental friendliness and chemical economy. Effect

CN102680439AInactive Publication Date: 2012-09-19INST OF CHEM CHINESE ACAD OF SCI
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Patent Information

Authority / Receiving Office
CN · China
Current Assignee / Owner
Publication Date
2012-09-19
Estimated Expiration
Not applicable · inactive patent

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Abstract

The invention belongs to the fields of micro-nano materials and photochemical analysis, and relates to a universal and efficient multi-band-gap photonic crystal microchip for detecting multiple substrates. The photonic crystal microchip arranged in array is prepared through fast self-assembly of multi-sprayer fine ink-jet printing technology and polyacrylic acid-polymethyl acrylate (shell)-polystyrene (core) polymer nano spheres. The microchip is provided with a design of full-band-gap photonic crystal array, and can perform fluorescence enhancement and amplification to fluorescent chemosensors such as oligomerization ethylenediamine and the like marked by 8-quinolineol or dansyl chloride at different wavelengths, and identifiable detection and analysis of the multi-substrate which cannot be finished by a single and a simple chemosensor can be achieved. By building a multi-band-gap photonic crystal micro-array, detection and analysis of the multiple substrates using the single chemosensor is achieved. The microchip has broad-spectrum universality and high operability in identification and detection of the multi-substrate in various complicated environments.
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Description

technical field

[0001] The invention belongs to the field of micro-nano materials and photochemical analysis, in particular to a photonic crystal high-efficiency and general-purpose multi-substrate detection and analysis microchip arranged in multiple forbidden bands. Background technique

[0002] The detection and analysis of multiple substrates and complex environments has very realistic research significance and application prospects for industry, food monitoring and living organism analysis. Based on organic fluorescent compounds, although scientists have developed hundreds of thousands of organic compounds that can be used in sensors, the response of a single chemical sensor is single or very limited, and it is usually impossible to realize the recognition and analysis of multiple substrates. Based on combinatorial chemical design and compound array chip technology, scientists such as Anslyn have developed a sensor array that uses a variety of sensor compounds to realiz...

Examples

Embodiment 1

[0037] 1) Select 4-pyrenyl-8-hydroxyquinoline as the chemical sensor, and measure the reaction of 4-pyrenyl-8-hydroxyquinoline on AlCl in tetrahydrofuran (THF) solution respectively. 3 , FeCl 3 , CoCl 2 , NiCl 2 , CuCl 2 , ZnCl 2 , HgCl 2 , CdCl 2 , CaCl 2 , MgCl 2 Fluorescence spectra of metal cation responses. (Such as image 3) According to the fluorescence spectrum characteristics of 4-pyrenyl-8-hydroxyquinoline metal cation response, photonic crystal arrays with forbidden bands at 390nm (near ultraviolet), 450nm (blue), 540nm (yellow) and 610nm (red) were selected to form an array. Detection analysis.

[0038] 2) Prepare polyacrylic acid-polymethyl acrylate (shell)-polystyrene (core) polymer nanoemulsion particles by block emulsion polymerization, and use surfactant (sodium dodecylsulfonate) to adjust and control the preparation Latex microspheres with different particle sizes (150-350nm).

[0039] 3) The photonic crystal latex microsphere emulsion with the fo...

Embodiment 2

[0047] 1) Select 8-quinolinol as the chemical sensor, and measure the reaction of 8-quinolinol on AlCl in tetrahydrofuran (THF) solution respectively. 3 , FeCl 3 , CoCl 2 , NiCl 2 , CuCl 2 , ZnCl 2 , HgCl 2 , CdCl 2 , CaCl 2 , MgCl 2 Fluorescence spectra of metal cation responses. (Such as image 3) According to the fluorescence spectrum characteristics of the 8-quinolinol metal cation response, photonic crystal arrays with forbidden bands at 390nm (near ultraviolet), 450nm (blue), 540nm (yellow) and 610nm (red) were selected for detection and analysis.

[0048] 2) Prepare polyacrylic acid-polymethyl acrylate (shell)-polystyrene (core) polymer nanoemulsion particles by block emulsion polymerization, and use surfactant (sodium dodecylsulfonate) to adjust and control the preparation Latex microspheres with different particle sizes (150-350nm).

[0049] 3) The photonic crystal latex microsphere emulsion with the forbidden bands prepared in step 2) at 390nm (near ultrav...

Embodiment 3

[0057] 1) Select dansyl-triethylenediamine as the chemical sensor, and measure the reaction of dansyl-triethylenediamine on AlCl in tetrahydrofuran (THF) solution respectively. 3 , FeCl 3 , CoCl 2 , NiCl 2 , CuCl 2 , ZnCl 2 , HgCl 2 , CdCl 2 , CaCl 2 , MgCl 2 Fluorescence spectra of metal cation responses. (Such as image 3) According to the fluorescence spectrum characteristics of dansyl-triethylenediamine metal cation response, photonic crystal arrays with forbidden bands at 430nm (blue), 480nm (cyan), 500nm (green) and 550nm (yellow) were selected for detection and analysis .

[0058] 2) Prepare polyacrylic acid-polymethyl acrylate (shell)-polystyrene (core) polymer nanoemulsion particles by block emulsion polymerization, and use surfactant (sodium dodecylsulfonate) to adjust and control the preparation Latex microspheres with different particle sizes (150-350nm).

[0059] 3) The photonic crystal latex microsphere emulsions with forbidden bands at 430nm (blue), ...