Method for preparing novel individual degradable artificial intraosseous stent

Abstract

The invention discloses a method for preparing a novel individual degradable artificial intraosseous stent, which belongs to the technical field of biomedicine. The method comprises the following steps of making a light-cured resin mold of which the form is consistent with the marrow cavity of a tubular bone massive comminuted fracture segment by using a rapid forming technology; and pouring an artificial intraosseous stent by using a compound material. The stent has the advantages of easiness in operating, reliable curative effect, high bone healing speed and small quantity of complications when applied to operation of tubular bone massive comminuted fractures, can be particularly applied to treatment of comminuted fractures of tubular bone metaphysis, and has very high potential clinical application value.

Description

technical field [0001] The invention belongs to the technical field of biomedicine, relates to the technology of repairing and treating tubular bone defects, and specifically relates to a method for preparing a novel individualized degradable artificial intramedullary stent. Background technique [0002] High-energy trauma causes comminuted fractures of the tubular bones of the extremities, resulting in segmental bone defects of the tubular bones. The treatment of large segmental comminuted fractures of the tubular bone is not only extremely difficult, but also requires a large amount of bone graft, and also needs to meet various biological functions such as postoperative load-bearing, especially the clinical treatment of such fractures involving the metaphysis is difficult Larger, postoperative fracture nonunion and deformities such as shortening of the affected limb have a high probability, so comminuted fractures of large segments of tubular bones have always been a very ...

AI Technical Summary

Problems solved by technology

There are several kinds of bone transplantation techniques at present: 1) Although autologous bone transplantation has great advantages, the lack of autologous bone mass, donor site infection, postoperative pain and other reasons limit the use of autologous bone transplantation to a large extent. use

2) Although various bone banks have been established to solve the problem of source of allogeneic bone, the residual immunogenicity and the missed diagnosis of pathogenic bacteria are inevitable, coupled with the destruction of osteogenic activity during the treatment process, resulting in bone loss after surgery. Slow healing, many complications

3) Artificial bone has no immune rejection, strong plasticity, and good biocompatibility, but has no osteogenic activity, and slow bone healing is its Achilles heel

The research on a variety of artificial bone composite materials and the addition of growth factors (such as BMP, FGFs, TGF2, etc.) have greatly improved the bone healing speed, but so far, no satisfactory artificial bone substitute material has been found.

Images