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Novel composite sun-screening agent nano-structure lipid carrier and preparation method thereof

A technology of nano-structured lipids and compound lipids, which is applied in pharmaceutical formulations, cosmetic preparations, cosmetic preparations, etc., can solve the problems of low loading, low stability of sunscreens, and inability of sunscreens to protect against UV rays, and achieves The effect of increasing load capacity, reducing drug leakage, and increasing SPF value

Inactive Publication Date: 2012-10-03
SOUTHEAST UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0008] The purpose of the present invention is to provide a novel composite sunscreen agent nano-structured lipid carrier with high stability, high loading capacity and high sun protection index, which solves the problem of low stability of sunscreen agents in the prior art, low load capacity, and the inability of a single sunscreen agent Full-band UV protection and other issues

Method used

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  • Novel composite sun-screening agent nano-structure lipid carrier and preparation method thereof
  • Novel composite sun-screening agent nano-structure lipid carrier and preparation method thereof
  • Novel composite sun-screening agent nano-structure lipid carrier and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0036] Embodiment 1 Preparation of novel composite sunscreen agent nanostructure lipid carrier

[0037] Composition formula

[0038]

[0039] Such as figure 1 Shown, the preparation steps of this embodiment are as follows:

[0040] 1. Weigh 9.6 grams of ceteareth-6 olive oil, 2.4 grams of cetearyl olive oil, 1.5 grams of acetylated monoglycerides, and 13.5 grams of caprylyl capric acid glycerides into a beaker , heated in a water bath at 75°C.

[0041] 2. After the lipid and emulsifier in the beaker are completely melted, add 1.7 g of ethylhexyl triazone and 3.3 g of diethylamino hydroxybenzoyl hexyl benzoate, and heat to dissolve for 30 minutes.

[0042] 3. Weigh 68.0 g of deionized water into a beaker, and heat in a water bath at 75°C.

[0043] 4. Add the water phase to the above system, stir evenly, and at the same time, turn on the high-pressure homogenizer and preheat it with 75°C deionized water;

[0044] 5. Inject the uniformly stirred high-temperature emulsion sy...

Embodiment 2

[0046] Embodiment 2 Preparation of novel composite sunscreen agent nanostructure lipid carrier

[0047] Composition formula

[0048]

[0049]

[0050] Preparation steps:

[0051] 1. Weigh 9.6 grams of ceteareth-6 olive oil, 2.4 grams of cetearyl olive oil, 1.5 grams of acetylated monoglycerides, 12.0 grams of glyceryl caprylate, 1.5 grams Glyceryl monostearate was put into a beaker and heated in a water bath at 75°C.

[0052] 2. After the lipid and emulsifier in the beaker are completely melted, add 3.3 grams of ethylhexyl triazone and 6.7 grams of diethylamino hydroxybenzoyl hexyl benzoate, and heat to dissolve for 30 minutes.

[0053] 3. Weigh 63.0 g of deionized water into a beaker, and heat it in a water bath at 75°C.

[0054] 4. Add the water phase to the above system, stir evenly, and at the same time, turn on the high-pressure homogenizer and preheat it with 75°C deionized water;

[0055] 5. Inject the uniformly stirred high-temperature emulsion system into a ...

Embodiment 3

[0057] Example 3 Preparation of Novel Composite Sunscreen Agent Nanostructured Lipid Carrier

[0058] Composition formula

[0059]

[0060] Preparation steps:

[0061] 1. Weigh 9.6 grams of ceteareth-6 olive oil, 2.4 grams of cetearyl olive oil, 1.5 grams of acetylated monoglycerides, 12.0 grams of glyceryl caprylate, 1.5 grams Glyceryl monostearate was put into a beaker and heated in a water bath at 75°C.

[0062] 2. After the lipid and emulsifier in the beaker are completely melted, add 10.0 g of ethylhexyl triazone and 20.0 g of diethylamino hydroxybenzoyl hexyl benzoate, and heat to dissolve for 30 minutes.

[0063] 3. Weigh 43.0 g of deionized water into a beaker, and heat it in a water bath at 75°C.

[0064] 4. Add the water phase to the above system, stir evenly, and at the same time, turn on the high-pressure homogenizer and preheat it with 75°C deionized water;

[0065] 5. Inject the uniformly stirred high-temperature emulsion system into a high-pressure homoge...

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Abstract

The invention discloses a novel composite sun-screening agent nano-structure lipid carrier. The carrier is loaded with two active ingredients, i.e., ethylhexyl triazone and diethylaminohydroxylbenzoylhexyl benzoate, and is characterized in that: the nano-structure lipid carrier comprises the following components in percentage by weight: 1-10 percent of ethylhexyl triazone, 2-20 percent of diethylaminohydroxylbenzoylhexyl benzoate, 3-15 percent of an emulsifying agent, 10-15 percent of a composite lipid material and the balance of deionized water, wherein the composite lipid material is a mixture of a solid lipid material and a liquid lipid material, and is selected from at least one of the following compounds: caprylic capric triglyceride, acetylated monoglyceride, glycerin monostearate, grape seed oil and glyceride L. The nano-structure lipid carrier has high stability; and a preparation method of the nano-structure lipid carrier is simple and controllable, has high repeatability, and can be applied to preparation of a cosmetic containing ethylhexyl triazone and diethylaminohydroxylbenzoylhexyl benzoate.

Description

technical field [0001] The invention belongs to the technical field of carrier systems in cosmetics preparation technology, relates to a nano-scale carrier and a preparation method thereof, in particular to a drug active drug containing ethylhexyl triazone and diethylamino hydroxybenzoyl hexyl benzoate Ingredient nanostructured lipid carriers and methods for their preparation. Background technique [0002] Sunscreen cosmetics are a hot spot in the development of the global cosmetics industry in recent years. With the improvement of people's living standards, the requirements for the design of sunscreen products have also developed from UVB protection to organic molecule protection that takes into account UVA. [0003] SPF is the protection against UVB in sunscreen cosmetics. Generally speaking, the SPF of the lowest sunscreen products is SPF2-6, the medium sunscreen product is SPF6-8, the high-end sunscreen product is SPF8-12, and the products with SPF value in the range o...

Claims

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Application Information

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IPC IPC(8): A61K8/06A61K8/49A61K8/44A61K8/92A61K8/86A61Q17/04
Inventor 夏强陈衍玲
Owner SOUTHEAST UNIV
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