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Echinacea extract and preparation method of echinacea extract

A technology of Echinacea purpurea extract and Echinacea purpurea, applied in the direction of drug combination, medical formula, plant raw materials, etc., can solve the problem of low content of active ingredients, and achieve the effect of no drug residue, high safety and good curative effect

Active Publication Date: 2014-11-12
QILU ANIMAL HEALTH PROD
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  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0006] The purpose of the present invention is to solve the problem that the content of active ingredients in the existing Echinacea purpurea extract is relatively low, and to provide a new preparation method for the echinacea purpurea extract, thereby achieving a significant increase in the content of its active ingredients polysaccharides, polyphenols and cichoric acid The purpose is to greatly improve the prevention and treatment effect of Echinacea purpurea extract on poultry diseases

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  • Echinacea extract and preparation method of echinacea extract

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Embodiment 1

[0029] Example 1. Preparation method and test comparison of Echinacea purpurea extract.

[0030] Example 1.1. Reflux extraction in a 30% ethanol solution with a pH of 12, and the filter residue is soaked and extracted with 1% lysozyme aqueous solution

[0031]Take 2kg of Echinacea purpurea, add 16kg of 30% ethanol solution, adjust the pH to 12 with Ca(OH)2, soak for 1 hour, and reflux extraction 3 times, 2 hours each time, combine the extracts, and filter with double-layer filter paper , combined the filtrates to obtain the alcohol extract; add 20kg of 1% lysozyme aqueous solution to the filter residue, soak for 12 hours at 37°C, filter, discard the filter residue, and suction filter the extract with double-layer filter paper, combine the filtrate with the previous alcohol extract, and wash with hydrochloric acid Adjust the pH value to 4.7 and let it stand for 3 hours; filter, precipitate and dry, and then pulverize to obtain 124g of echinacea precipitated powder. The precip...

Embodiment 1

[0039] Embodiment one.4. Conventional water immersion extraction

[0040] Take 2kg of Echinacea purpurea, add 16kg of water, soak for 1 hour, decoct 3 times, 2 hours each time, combine the water decoction, filter with double-layer filter paper, combine the filtrate, concentrate the filtrate to a density of 1.15g / ml, filter, and filtrate Spray-dried to obtain 364g of Echinacea purpurea powder.

[0041] The content of polysaccharides and polyphenols in the above-mentioned Echinacea purpurea extract was detected by ultraviolet spectrophotometer, and the result was 19.46% of polysaccharides and 3.62% of polyphenols; the content of cichoric acid in the above-mentioned Echinacea purpurea extract was detected by high-performance liquid chromatography , The result was 0.36% cichoric acid.

Embodiment 1

[0042] Example 1.5. Conventional ethanol extraction

[0043] Take 2 kg of Echinacea purpurea medicinal material, add 16 kg of ethanol solution with a concentration of 30%, soak for 1 hour, and reflux extraction 3 times, each time for 2 hours, combine the extracts, suction filter with double-layer filter paper, combine the filtrates, and recover the ethanol from the filtrate under reduced pressure to nothing. Alcoholic taste, continue to concentrate to a density of 1.15g / ml, and spray dry to obtain 261g of Echinacea purpurea powder.

[0044] The content of polysaccharides and polyphenols in the above-mentioned Echinacea purpurea extract was detected by ultraviolet spectrophotometer, and the result was 16.92% of polysaccharides and 5.43% of polyphenols; the content of cichoric acid in the above-mentioned Echinacea purpurea extract was detected by high-performance liquid chromatography , The result was 1.24% cichoric acid.

[0045] Can find out by embodiment 1.1-5. five experim...

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Abstract

The invention relates to an echinacea extract and a preparation method of the echinacea extract. The echinacea extract provided by the invention is obtained through carrying out twice extraction on echinacea medicinal materials by alkaline ethanol solution and lysozyme; and in the product, the polysaccharide content is greater than or equal to 21.50 percent, the polyphenol content is greater than or equal to 8.10 percent, and the chicoric acid content is greater than equal to 5.00 percent. Because the polyphenol content and the chicoric acid content of the echinacea extract are obviously increased, the echinacea extract is prepared into ordinary preparations including powder or oral liquid and the like, and the curative effect is greatly improved. In a compound preparation processed by the echinacea extract and bacteriolysant according to a consumption ratio being 3:1, active ingredients of echinacea and lysozyme totally account for 20 percent, wherein the consumption ratio of the echinacea extract to the lysozyme is (4-1):1, auxiliary materials of cane sugar account for 64 percent, and dextrin accounts for 16 percent. The compound preparation has the functions of improving the immunity of live stock and realizing the sterilization and antivirus functions, and can be used as medicine for preventing and treating animal diseases, particularly chicken diseases caused by escherichia coli infection.

Description

technical field [0001] The invention belongs to the field of herbal medicines, and relates to an animal immune enhancer, in particular, to an extract of Echinacea purpurea and its preparation method and application. Background technique [0002] Echinacea purpurea is currently a kind of immunostimulant that is widely valued by the world, and its extract and preparation sales rank among the top 5 in the US pharmaceutical market. Its medicinal history can be traced back to the time of North American Indians. This genus of plants has been regarded as the best medicine for treating trauma, snake bites, headaches and colds. It has outstanding anti-infection and immune-promoting effects, and has attracted great attention from abroad. At present, in China, it is mainly used to enhance immunity, anti-inflammation, and anti-virus. Compared with antibiotics in terms of antibacterial and anti-virus, it can overcome the problems of drug resistance and drug-induced reactions that often o...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K36/28A61K38/47A61P31/04A61P31/14A61P31/16A61P31/20A61P31/22A61P37/04
Inventor 王海挺李成应冉蓉王雅琪吴连勇孔梅田玉柱崔进
Owner QILU ANIMAL HEALTH PROD
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