Preparation method of prulifloxacin

A technology of prulifloxacin and reaction kettle, applied in the direction of organic chemistry and the like, can solve the problems of difficulty in source and storage, poor reactivity and effect, low reactivity, etc., and achieves the advantages of industrialized production, easy operation, and high activity in the preparation process. Effect
CN102718781BActive Publication Date: 2015-04-29SICHUAN KELUN PHARMA RES INST CO LTD
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Patent Information

Authority / Receiving Office
CN ยท China
Patent Type
Patents(China)
Current Assignee / Owner
SICHUAN KELUN PHARMA RES INST CO LTD
Publication Date
2015-04-29

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Abstract

The invention relates to a synthetic method of prulifloxacin, comprising the steps of: stirring DMDO-Cl and sodium iodide in an organic solvent, carrying out a one-pot reaction of the unseparated reaction liquid, a compound 2 and alkali substances to obtain the prulifloxacin. The synthetic method of the invention is advantaged in that the raw material DMDO-Cl used in the invention is cheap, easily available, and easily stored and transported, the prulifloxacin synthesized by the method has high yield, increased purity, and the operation is convenient.
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Description

technical field

[0001] The invention relates to a new preparation method of quinolone antibacterial drugs, in particular to a preparation method of prulifloxacin. Background technique

[0002] Prulifloxacin is a fluoroquinolone antibacterial drug jointly developed by Nippon Shinyaku Co., Ltd. and Meiye Zhika Co., Ltd. It was first launched in Japan in 2002. This product has broad-spectrum antibacterial activity, the antibacterial activity against Staphylococcus aureus is similar to ofloxacin (ofloxacin), greater than ciprofloxacin (ciprofloxacin), the activity against streptococcus is 5 times greater than ofloxacin, and the activity against large intestine The activity of bacilli is equivalent to that of ciprofloxacin, and its antibacterial activity against Klebsiella pneumoniae, Serratia marcescens, and Pseudomonas aeruginosa is 2 to 3 times greater than that of ciprofloxacin and ofloxacin, and it can be used clinically to treat pneumonia , Acute and chronic bronchitis, ph...

Claims

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