Evodiamine dispersion tablets and preparation method thereof

A technology of evodial alkaloid and dispersible tablet, which is applied in the field of evodial alkaloid dispersible tablet and its preparation, and achieves the effects of high dispersion uniformity, favorable absorption and improved bioavailability

Inactive Publication Date: 2012-10-17
TEACHING HOSPITAL OF CHENGDU UNIV OF T C M
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] At present, there is no report on preparing evodiamine into dispersible tablets

Method used

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  • Evodiamine dispersion tablets and preparation method thereof
  • Evodiamine dispersion tablets and preparation method thereof
  • Evodiamine dispersion tablets and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0027] Embodiment 1 The preparation of evodiamine dispersible tablets of the present invention

[0028] Evodiamine dispersible tablets include the following weight percentage components to make 1000 tablets

[0029]

[0030] Preparation method: (1) Weigh the raw and auxiliary materials according to the prescription ratio;

[0031] (2) Take evodiamine, grind it to a particle size of 1-10 μm, mix it with poloxamer 188, and prepare a solid dispersion by melting;

[0032] Melting method of the present invention can be carried out according to conventional method, or adopt following operating steps:

[0033] Melt the poloxamer in a constant temperature water bath at 80°C, add evodiamine, stir evenly, pour it out quickly, and move it to -20°C to freeze and solidify, take it out and dry it, crush it, and sieve it for later use.

[0034] (3) Take the solid dispersion prepared in step (2), crush it through an 80-mesh sieve, and mix it evenly with microcrystalline cellulose, lactos...

Embodiment 2

[0036] Embodiment 2 Preparation of evodiamine dispersible tablets of the present invention

[0037] Evodiamine dispersible tablets include the following weight percentage components to make 1000 tablets

[0038]

[0039] Preparation method: (1) Weigh the raw and auxiliary materials according to the prescription ratio;

[0040] (2) Take evodiamine and grind it to a particle size of 1-10 μm, then mix it with PEG-6000, and prepare a solid dispersion by melting method;

[0041] (3) Take the solid dispersion prepared in step (2), crush it through an 80-mesh sieve, mix it with microcrystalline fiber, lactose, L-HPc, PVPP, aspartame, magnesium stearate and micropowder silica gel, and then directly Tablet

Embodiment 3

[0042] Embodiment 3 Preparation of Evodia Evodia Dispersible Tablets of the present invention

[0043] Evodiamine dispersible tablets include the following weight percentage components to make 1000 tablets

[0044]

[0045] Preparation method: (1) Weigh the raw and auxiliary materials according to the prescription ratio;

[0046] (2) Take evodiamine and grind it to a particle size of 1-10 μm, then mix it with PEG-4000, and prepare a solid dispersion by melting method;

[0047] (3) Take the solid dispersion prepared in step (2), crush it through an 80-mesh sieve, mix it with microcrystalline fiber, L-HPc, PVPP, aspartame, magnesium stearate and micropowder silica gel, and then directly compress it into tablets

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PUM

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Abstract

The present invention provides a drug for treating hyperuricemia and gout, ie., evodiamine dispersion tablets. The evodiamine dispersion tablets are the preparation prepared from the following raw materials and additives, by weight, 7-13 parts of evodiamine, 30-50 parts of a solid dispersion water-soluble carrier material, 70-90 parts of a filler, and 8-14 parts of a disintegrating agent. The present invention further provides a preparation method and uses of the dispersion tablets. The evodiamine dispersion tablets of the present invention have characteristics of short disintegration time and high dispersion uniformity. According to the present invention, the dissolution of the insoluble drug evodiamine in the solid preparation can be significantly improved, the absorption of the evodiamine in the human body is prompted, the bioavailability of the drug is increased, and new selections are provided for clinical medication for treatments of hyperuricemia and gout.

Description

technical field [0001] The invention relates to an evodiamine dispersible tablet and a preparation method thereof. Background technique [0002] Evodiamine is the main medicinal ingredient of Evodia rutaecarpa. Modern pharmacological studies have shown that evodiamine has pharmacological activities such as dilating blood vessels, anti-inflammation, analgesia, weight loss, regulating body temperature, anti-tumor and inhibiting cancer cell metastasis, and has broad development prospects. Through long-term experiments, it has been found that evodiamine also has the effect of significantly lowering blood uric acid and resisting animal acute gouty arthritis foot swelling, and can be applied to the treatment of hyperuricemia and gout (Song Ying, et al., Evodiamine in the treatment of gout. Scientific Research, Pharmacology and Clinical Practice of Traditional Chinese Medicine, Issue 6, 2011). However, evodiamine is insoluble in water. If it is prepared into a common oral preparat...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/20A61K31/519A61P19/06
Inventor 宋英盛蓉谈静袁燕李涓刘莉陈佳
Owner TEACHING HOSPITAL OF CHENGDU UNIV OF T C M
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