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Chinese medicine active component composition capable of relaxing blood vessels

An active ingredient and vasodilator technology, applied in the field of active ingredient compositions of traditional Chinese medicine, can solve the problems of unclear active ingredients, too many prescription drugs, and low standard levels, and achieve a clear mechanism of action, clear effective substances, and controllable quality. Effect

Inactive Publication Date: 2012-10-24
CHINA PHARM UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, most of the existing traditional Chinese medicine compound medicines have too many prescriptions, large dosage, unclear active ingredients, unstable quality, and low standard level, which cannot be accepted by the international market, and the application of Chinese medicine in clinical treatment cannot compete with Western medicine.

Method used

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  • Chinese medicine active component composition capable of relaxing blood vessels
  • Chinese medicine active component composition capable of relaxing blood vessels

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0019] Embodiment 1: the preparation of composition

[0020] 5 kinds of active ingredients and 5 doses of high, second high, medium, low and zero, according to the orthogonal experiment design 5 factors 5 levels table [L 25 (5 6 )], forming a combination of different weight ratios.

Embodiment 2

[0021] Embodiment 2: Rat thoracic aortic vessel ring experiment

[0022] Pinoresinol diglucoside, rhynchophylline, leonurine, prunella saponin and baicalin were prepared according to Example 1. The pinoresinol diglucoside and leonurine solution used K-H nutrient solution as a solvent, and the baicalin solution used dimethyl The sulfoxide is used as a solvent, and the solution of rhynchophylline and prunella vulgaris saponin uses ethanol as a solvent, wherein the final concentration of dimethyl sulfoxide and ethanol is less than 0.1%.

[0023] In each group of experiments, 5 kinds of active ingredient solutions were mixed according to different proportions and added to the bath. The final concentration of each active ingredient was consistent with the design of the orthogonal experiment, and each group of experiments was repeated 6 times.

[0024] Rat thoracic aorta vascular ring experiment screening, according to the vasodilation effect, the weight ratio of the composition wit...

Embodiment 3

[0027] Embodiment 3: experiment on spontaneously hypertensive rats

[0028] Pinoresinol diglucoside, rhynchophylline, leonurine, prunella saponin and baicalin, the compositions screened according to Example 2, were given by intragastric administration with SHR, and the systolic pressure of the tail artery of rats was detected for a total of four weeks. Single-component and composition administration results are as follows:

[0029] The influence of table 2 single component and composition on SHR systolic blood pressure (n=6)

[0030]

[0031] Note: Compared with blank control group, *P<0.05; **P<0.01

[0032] The results showed that: with the growth of age, the blood pressure of SHR rats was also increasing, from about 180mmHg to about 195mmHg in four weeks, and the single component of five vasodilation active ingredients could reduce the systolic pressure of tail artery of SHR rats , after combining the five active ingredients of pinoresinol diglucoside, rhynchophylline,...

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Abstract

The invention discloses a Chinese medicine active component composition capable of relaxing blood vessels. The composition comprises active components including pinoresinol diglucoside, rhynchophylline, leonurine, selfheal saponin and baicalin extracted from five common blood pressure reducing Chinese medicines including eucommia bark, uncaria, leonurus, selfheal and radix scutellariae, and the weight ratio of the pinoresinol diglucoside to the rhynchophylline to the leonurine to the selfheal saponin to the baicalin is 12:8:8:1:2. The composition can remarkably relax rat thoracic aorta vasoconstriction caused by norepinephrine, and can reduce spontaneously hypertensive rat (SHR) tail systolic arterial pressure. As the five Chinese medicines are clinical common blood pressure reducing medicines and are compatible with compound eucommia bark tablets recorded in the sixth volume of Chinese medicine component preparations from drug standards in department of health, the Chinese medicine active component composition capable of relaxing the blood vessels can serve as a clinical blood pressure reducing medicine.

Description

technical field [0001] The invention relates to a traditional Chinese medicine active component composition for relaxing blood vessels and its application in medicine. The traditional Chinese medicine active ingredients contained in the composition are pinoresinol diglucoside, rhynchophylline, motherurine, prunella vulgaris saponin and baicalin, and the total content of the active ingredients meets the requirements of the national new drug declaration of traditional Chinese medicine. The composition can be used as a blood pressure lowering drug for clinical application. Background technique [0002] Hypertension is one of the most common cardiovascular diseases, with a large number of patients, and the incidence rate is increasing year by year. At the same time, hypertension is a major risk factor for stroke and coronary heart disease, so effective prevention and treatment of it has become a public health issue of common concern worldwide. Investigations have shown that th...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/7048A61K31/7024A61K31/4375A61K31/235A61P9/08A61P9/12
Inventor 卞筱泓许激扬赵刚刚许娟王旻
Owner CHINA PHARM UNIV
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