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Extraction method of traditional Chinese medicinal materials

An extraction method and technology of traditional Chinese medicinal materials, which are applied in pharmaceutical formulations, antipyretics, drug combinations, etc., can solve the problems of large differences in yield and chemical composition, mildew of extracts, and high equipment costs, and achieve high utilization of medicinal materials. and extraction rate, low extraction temperature, and the effect of reducing paste yield

Active Publication Date: 2012-11-07
四川乐嘉药业有限公司
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  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The maturity of supercritical fluid extraction and subcritical water extraction is not high
Although supercritical extraction has many advantages compared with other extraction methods, the yield and chemical composition are very different; process changes and the resulting drug equivalence and toxicity are issues that should be studied; supercritical extraction devices are high-pressure equipment, there are problems such as high equipment cost and safety, and should also be paid attention to when promoting applications
At the same time, they have high requirements for equipment precision and high cost, and more investment is required to realize large-scale production in enterprises
[0004] The maceration method is a static extraction method, which is to crush the medicinal materials and soak them for extraction. The energy consumption is low, but the extraction cycle is long. When the water is used as a solvent for extraction, it will cause mildew in the extract and affect the safety of the preparation; the extraction process by pressing, It is mainly used in the extraction of vegetable oil and sugar in the food industry, and has a high degree of maturity. However, in the field of traditional Chinese medicine, it is only used for the separation of liquid from medicinal residues, and there are no reports on the extraction of medicinal materials.
[0005] At present, there are no relevant reports on the combination of maceration and pressing methods used in the extraction of Chinese herbal medicines

Method used

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  • Extraction method of traditional Chinese medicinal materials

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0018] Embodiment 1 Extraction method of the present invention

[0019] (1) Take Chinese herbal medicines, steam them for 10-30 minutes, and slice them;

[0020] (2) Take the steamed Chinese medicinal materials, add 11 times the weight of water, soak for 4 hours, and the soaking temperature is 60°C;

[0021] (3) Squeeze the soaked Chinese herbal medicine together with the soaking solvent while it is hot to extract the juice, the pressing pressure is 25-30MPa, and the extract and dregs are used for later use;

[0022] (4) Take the dregs of the medicine, add water to wash twice, and combine the obtained washing liquid with the extract of step (3) to obtain the Chinese medicinal material extract; wherein, the specific operation of washing is as follows: take 2 times the weight of the original Chinese medicinal material in water, After mixing, squeeze the juice under 25-30MPa to obtain the washing liquid.

[0023] Taking Radix Astragali as an example, Scutellaria baicalensis is ...

Embodiment 2

[0024] Embodiment 2 The screening of Chinese medicine extraction method of the present invention

[0025] Taking Scutellaria baicalensis as an example, study the optimal process of the method of the present invention.

[0026] 1 Experimental instruments and materials

[0027] 1.1 Instrument

[0028] LC-10AT high performance liquid chromatography (Shimadzu Corporation of Japan); UV-1700 ultraviolet spectrophotometer (Shimadzu Corporation of Japan); BP211D electronic analytical balance (Sartorius Corporation of Germany); DZF-1B vacuum drying oven (Shanghai Yuejin Medical equipment factory); squeezer (Henan Jinnai Technology Development Co., Ltd.); electronic constant temperature water bath (Beijing Zhongxing Weiye Instrument Co., Ltd.); SZ-93 automatic double pure water distiller (Shanghai Yarong Biochemical Instrument Factory).

[0029] 1.2 Materials

[0030] Scutellaria baicalensis pieces (Sichuan Kelun Natural Medicine Liquid Co., Ltd., batch number: 120302); baicalin refe...

Embodiment 3

[0060] Embodiment 3 The comparison of the extraction method of the present invention and the traditional soaking method

[0061] Traditional warm soaking method: take Scutellaria baicalensis slices and steam for 30 minutes, soak at 60°C for 4 hours, take 11 times the amount of water, after the first extraction, measure the content of baicalin according to the method of Example 2, the content of baicalin is 72 mg / g; The slag was then soaked in 10 times the amount of water for 3 hours, and the content of baicalin after the second extraction was measured to be 19 mg / g, and the total content of baicalin in the two warming experiments was 91 mg / g.

[0062] According to the optimal process of "soaking-pressing" screened out in Example 2 of the present invention, the content of baicalin is 109 mg / g, and compared with the traditional warm soaking method for one extraction, the content of baicalin has increased by 51%; compared with the traditional warm soaking method Compared with the...

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PUM

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Abstract

The invention provides an extraction method of traditional Chinese medicinal materials, which is a new method applied to the extraction of the traditional Chinese medicinal materials after combining an immersion method and a pressing method. According to the invention, the extraction method obtained by combining the immersion method and the pressing method is capable of only more completely extracting the effective components in the medicinal materials and guaranteeing higher utilization ratio and extraction ratio of the medicinal materials, but also effectively reducing the extraction amount, thereby being convenient for the preparation at later period. The extraction method provided by the invention has the advantages of low extraction temperature, less solvent dose, and the like, is capable of saving a plurality of cost, and is beneficial for saving energy and environmental protection, thereby providing a new idea for an extraction technology of the traditional Chinese medicinal materials.

Description

technical field [0001] The invention relates to a new method for extracting Chinese medicinal materials. Background technique [0002] Scutellaria baicalensis is the dry root of Scutellaria baicalensis, a plant of the Labiatae family. It is one of the traditional bulk medicinal materials in my country. Anti-abortion and other effects, it is widely used clinically for lung heat, hemoptysis, enteritis and dysentery, jaundice, metrorrhagia, carbuncle and sore swelling. Scutellaria baicalensis medicinal materials are commonly extracted with water extraction and alcohol extraction, and water extraction is commonly used in industrial production. The extraction methods of Scutellaria baicalensis include decoction method, reflux method, room temperature immersion method, ultrasonic extraction method, microwave extraction method, supercritical water extraction method and subcritical water extraction method. [0003] The decoction method and the reflux method extraction are common me...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/539B01D11/02A61P29/00A61P11/00A61P7/04A61P15/06A61P1/12A61P17/02A61P39/02A61K125/00
Inventor 杨小容唐梅田开鑫
Owner 四川乐嘉药业有限公司