Looking for breakthrough ideas for innovation challenges? Try Patsnap Eureka!

Injection bone filling composition

A composition and injection technology, which is applied in the field of bone filling materials, can solve the problem of short operation time interval and achieve the effect of reducing the possibility of operation failure

Inactive Publication Date: 2012-11-07
FAR EASTERN NEW CENTURY COPRRATION
View PDF1 Cites 2 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Known calcium sulphate bone cements cannot meet these characteristic requirements due to the usually short operating time interval (approximately 2 minutes) available for modulation

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • Injection bone filling composition
  • Injection bone filling composition
  • Injection bone filling composition

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1～8

[0021] Take 7 grams of calcium sulfate hemihydrate (average particle size 10 μm) and 8 grams of HA (average particle size 2 μm) and mix them uniformly. Take 6 grams of distilled water, add it to the mixed powder at room temperature, and stir with a hand-held stirring rod at a stirring rate of 1 revolution / second for 50 seconds to form a slurry. Afterwards, after standing for 1, 3, 5, 7, 9, 11, 13, and 15 minutes, take 5 grams of the slurry respectively, use the AR-G2 rheometer (TA Instruments), and according to its operation manual, to Viscosity was determined by the parallel plate viscosity test method. At the same time, another 5 grams of slurry was filled into the injection cylinder (the inner diameter of the injection port was 0.3 cm), and then the slurry was extruded from the injection cylinder and injected into distilled water. The appearance of the slurry was then observed to see if it maintained its shape or fell apart. The test results are shown in Table 1:

[0022...

Embodiment 9～15

[0029] Take 15.8 grams of calcium sulfate hemihydrate (average particle size 950 nm) and 5.2 grams of HA (average particle size 42 μm) and mix them uniformly. Take 6.5 g of distilled water, add it to the mixed powder at room temperature, and then stir with a hand-held stirring rod at a stirring rate of 1 revolution / second for 50 seconds to form a slurry. Afterwards, after standing for 1, 3, 5, 7, 9, 11, and 13 minutes, take 5 grams of the slurry to test according to the detection methods and conditions of Examples 1-8, and the test results are shown in Table 2:

[0030] Table II

[0031]

[0032] Note: "+": easy to inject; "-": slightly difficult to inject, but still injectable; "—": unable to inject; "△": slightly spread out, but can still roughly maintain its shape; "○": won't fall apart

[0033] From the test results obtained in Examples 9-15, it can be found that the injectable bone filling composition of the present invention can be used as an injectable bone cement ...

Embodiment 16～22

[0037] Take 10 grams of calcium sulfate hemihydrate (average particle size 33 μm), 2.36 grams of HA (average particle size 9 μm) and 2.36 grams of tricalcium phosphate (average particle size 3 μm) and mix them uniformly. Take 6.5 g of physiological saline, add it to the above mixed powder at room temperature, and then stir with a hand-held stirring rod at a stirring rate of 1 revolution / second for 50 seconds to form a slurry. Afterwards, after standing for 1, 3, 5, 7, 9, 11, and 13 minutes, take 5 grams of the slurry to test according to the detection methods and conditions of Examples 1-8, and the test results are shown in Table 3:

[0038] Table three

[0039]

[0040] Note: "+": easy to inject; "-": slightly difficult to inject, but still injectable; "—": unable to inject; "△": slightly spread out, but can still roughly maintain its shape; "○": won't fall apart

[0041] From the test results obtained in Examples 16-22, it can be found that the injectable bone filling c...

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

PUM

PropertyMeasurementUnit
particle sizeaaaaaaaaaa
particle sizeaaaaaaaaaa
particle sizeaaaaaaaaaa
Login to View More

Abstract

The invention relates to an injection bone filling composition which is a semi-solid slurry. The slurry is mainly obtained by uniformly mixing a pulvis and a blended aqueous solution, wherein the pulvis includes a calcium sulfate powder and a calcium phosphate powder and the calcium phosphate accounts for 20-60 wt% of the gross weight of the pulvis; and the amount by weight of the blended aqueous solution is 20-50 parts relative to 100 parts by weight of the pulvis. The slurry has viscosity of 20,000 poise to 80,000,000 poise. The injection bone filling composition provided by the invention has a wide blending operation time period, which is beneficial to blending operation of bone cement for doctors and helps minimize the possibility of surgical failures.

Description

technical field [0001] The invention relates to a bone filling material, in particular to an injectable orthopedic filling material. Background technique [0002] Human bones are often malfunctioned or deformed due to accidental injury, disease or degeneration, which compresses organs and nerves. Medical treatment for this condition usually requires appropriate corrective surgery or implantation of replacement material to replace bone tissue in order to speed bone healing and restore some function. [0003] It is known that when repairing skeletal defects in an organism, large amounts of bone filling material are usually applied. Most of the artificial bone filling materials currently used clinically are made of biologically active ceramics, such as hydroxide apatite, tricalcium phosphate, or treated animal bones (allograft), etc., which are developed into granular or massive forms. Implantation of material to help bone repair by filling it directly into the area of ​​the ...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

Application Information

Patent Timeline
no application Login to View More
Patent Type & Authority Applications(China)
IPC IPC(8): A61L27/12A61L27/02
Inventor 黄若暐张根源陈柏仰张至宏许元铭
Owner FAR EASTERN NEW CENTURY COPRRATION
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Patsnap Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Patsnap Eureka Blog
Learn More
PatSnap group products

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic, Popular Technical Reports.

© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap|About US| Contact US: help@patsnap.com