Methods for synthesizing molybdopterin precursor z derivatives

A compound and reaction technology, applied in the field of synthesizing molybdenum pterin precursor Z derivatives, can solve problems such as limited availability of therapeutically active agents
CN102766165AInactive Publication Date: 2012-11-07阿莱克申药物国际公司
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Patent Information

Authority / Receiving Office
CN · China
Current Assignee / Owner
阿莱克申药物国际公司
Publication Date
2012-11-07
Estimated Expiration
Not applicable · inactive patent

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Abstract

Provided herein are synthetic methods for preparing a compound of formula (I): Also provided herein are synthetic methods for preparing a compound of formula (XIII): The disclosure also provides useful intermediates, derivatives, prodrugs, and pharmaceutically acceptable salts, solvates and hydrates of the formula (I) and formula (XIII) compounds. These compounds are useful for treating diseases associated with molybdenum cofactor deficiency.
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Description

[0001] Cross References to Related Applications

[0002] This application claims the benefit of U.S. Provisional Applications 61 / 444,389 filed February 18, 2011, 61 / 498,801 filed June 20, 2011, 61 / 498,808 filed June 20, 2011, and Priority of 61 / 599,314 filed, the entire contents of which are incorporated into this application by reference. technical field

[0003] The present application provides a synthetic method for preparing molybdopterin (molybdopterin) derivative precursor Z and a new synthetic intermediate for synthesizing it. The present application also provides useful intermediates, derivatives, prodrugs and pharmaceutically acceptable salts, solvates and hydrates of precursor Z. These compounds are especially useful in the treatment of diseases associated with molybdenum cofactor deficiency. Background technique

[0004] Molybdenum coenzyme (Moco) deficiency is a pleiotropic genetic disorder. Moco consists of molybdenum covalently linked to one or two dithiolat...

Claims

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