Composite gel for plant capsules and preparation method for composite gel

Abstract

The invention discloses composite gel for plant capsules and a preparation method for the composite gel. The composite gel is prepared by fully and evenly mixing raw materials in a mixing machine, wherein the raw materials comprise 1-15 parts of K-carrageenan, 0.5-7.5 parts of iota-carrageenan and 77.5-98.5 parts of component C (cellulose derivative and / or plant polysaccharide) in parts by weight. The composite gel for the plant capsules is proper in raw material ratio and can be suitable for producing various plant capsules, thus, the percent of pass of plant capsule products is greatly increased. Through controlling the viscosity and the temperature stability of the gel, the empty plant capsules meeting the standard of China pharmacopoeia are prepared. The waterproof rate and oxygen-proof rate of the capsules are improved and the waterproof effect and the oxygen-proof effect of the capsules are enhanced, thus, the content can be stabilized and the quality guarantee periods of the products can be prolonged. Meanwhile, the problems that the raw materials for producing the plant capsules are various, the operation is complicated and the quality standard is not stable and cannot be controlled are solved.

Description

technical field [0001] The invention relates to a film-forming material for capsules, in particular to a composite glue for vegetable capsules and a preparation method thereof. Background technique [0002] Medicinal empty capsules are a kind of pharmaceutical excipients (drug packaging materials), which are mainly used in drug homogeneous preparations. Generally, gelatin used in capsules is used as the main film-forming material, and it has a history of 100 years. In recent years, the disadvantages of gelatin empty capsules have gradually emerged, especially the high water content, high requirements for drug stability, and easy cross-linking reactions with compounds containing aldehyde groups. In addition, due to reasons such as Muslim fasting and potential zoonotic diseases, people began to look for vegetable film-forming materials to replace capsule gelatin to prepare medicinal hollow capsules. [0003] At present, some non-animal source film-forming materials have been ...

AI Technical Summary

Problems solved by technology

The disadvantage is that although the dosage of K-carrageenan is relatively low, potassium or calcium salt is added, and the formed potassium or calcium salt of K-carrageenan makes the capsule disintegrate for as long as 15-16.5 minutes, which does not meet the current Pharmacopoeia Standard (the disintegration time limit in the stomach is within 10 minutes)

[0008] There are many shortcomings in the above patented technology itself, and it is difficult to realize industrialization

At present, there are three kinds of plant capsules made of plant-based film-forming materials that can be seen on the market: the first is HPMC capsules produced by the US-owned Suzhou Capsule Company. The main raw material is hypromellose, but because of its raw material selection There is a problem with the quality standard of the capsule, which makes the appearance of the capsule rough and dull, with poor elasticity and long disintegration time; the second is the seaweed polysaccharide plant capsule of Qinhuangdao Pharmaceutical Capsule Company, the main raw materials are K-carrageenan and hypromellose, However, its raw material ratio and monomer quality standards are unstable, its production cost is high, and its qualified rate is low; the third type is the pullulan capsule produced by Jicheng Biotechnology in Yingxian County, Shanxi Province. The main raw material is pullulan polysaccharide, and the appearance of the product is very transparent. Good but poor toughness, the surface of the product is easy to absorb moisture and become sticky, the storage period is short and the requirements for storage conditions are high

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