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1, 7-meta dicarbadecaborane carboxylic acid triphenyl stannic chloride compound as well as preparation method and application of compound

A technology of meta-decaborane carboxylic acid and triphenyltin chloride, applied in tin organic compounds, organic chemistry, drug combination, etc., to achieve good fat solubility, low cost, and high anticancer activity

Inactive Publication Date: 2012-11-14
LIAOCHENG UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, there are few reports in the literature on dicarbocaborane dicarboxylate organotin compounds

Method used

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  • 1, 7-meta dicarbadecaborane carboxylic acid triphenyl stannic chloride compound as well as preparation method and application of compound

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0015] Will 1.0mmol m-c 4 B 10 H 12 O 4 , 2.0mmol net 3 Soluble at 15ml CH 3 In OH, then add 2.0 mmol pH 3 Sncl's CH 3 In the OH solution, after the normal temperature is 0.5h, the 1.0 mmol3,5-pyridine di carboxylic acid is added to the above-mentioned hybrid solution, and the normal temperature will be stirred for 12 hours.Filter, the filter fluid is static at room temperature.After the three-year period, the colorless crystal is obtained, and the melting point is 226-228 ° C.The production rate of this compound was 69.8%.

[0016] The organic tin compounds of the present invention are analyzed by infrared spectrum and X-single crystal diffraction analysis. The results are as follows: IR (KBR, CM -1 ): V = 1643.1, 1384.4 (COO), 543.9 (SN-C), 454.9 (SN-O).

[0017] Crystal data: The crystal system of this chemical compound belongs to the orthogonal crystal system, the space group is PBCA, and the crystal parameters are: A = 20.2440 (18)?, B = 18.2560 (15)?, C = 20.2435 (19)?, Α =9...

Embodiment 2

[0019] Will 1.0mmol m-c 4 B 10 H 12 O 4 (1,7-interval binocarboline carboxylic acid), 2.0 mmol net 3 Soluble at 15ml CH 3 In OH, then add 2.0 mmol pH 3 Sncl's CH 3 In the OH solution, after the normal temperature is 0.5h, the 1.0 mmol3,5-pyridine di carboxylic acid is added to the above-mentioned hybrid solution, and the normal temperature will be mixed for 16h.Filter, the filter fluid is static at room temperature.After the three-year period, the colorless crystal is obtained, and the melting point is 226-228 ° C.The production rate of this compound was 65.3%.

Embodiment 3

[0021] Will 1.0mmol m-c 4 B 10 H 12 O 4 , 2.0mmol net 3 Soluble at 15ml CH 3 In OH, then add 2.0 mmol pH 3 Sncl's CH 3 In the OH solution, after the normal temperature is 0.5h, the 1.0 mmol3,5-pyriarine di carboxylic acid is added to the above-mentioned hybrid solution, and the normal temperature will be stirred for 20 hours.Filter, the filter fluid is static at room temperature.After the three-year period, the colorless crystal is obtained, and the melting point is 226-228 ° C.The production rate of this compound was 64.6%.

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Abstract

The invention discloses a 1, 7-meta dicarbadecaborane carboxylic acid triphenyl stannic chloride compound and a preparation method thereof. The organotin compound has high anti-cancer activity and can be used for preparing medicaments for treating chronic myeloid leukemia erythroleukemia and cervical cancers as a raw material. Compared with a platinum anti-cancer drug which is generally used at present, the organotin compound has the characteristics of high anti-cancer activity, good lipid solubility, low cost, simple preparation method and the like.

Description

Technical field [0001] The present invention involves 1,7-inter-carbon ten-boron-carboxyl carboxylic acid triazol chloride pitching compounds and its preparation methods, as well as the application of the compound in anticancer drugs. Background technique [0002] Organic tin carboxylic acid matches are widely used in plastic, coatings, catalytic and insecticidal (fungi).In recent years, studies have shown that compounds containing or hydrolyzed can produce SN-O bonds have good biological activity and their potential anti-cancer activity, which has been increasingly valued by the door. [0003] Borne derivatives use boron neutron capture therapy in the treatment of cancer have potential application prospects. They show higher choice affinity to certain cancer cells in the human body.So far, some single-carbon acid components formed through dietary tenrane, such as {[1,7-C 2 B 10 H 11 -L-CoO) buu 2 SN] 2 O} 2 (Gielen M, Bouhdid A, Willem R, Bregadze Vi, Ericink Ert. J. Organometal...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C07F19/00C07F7/22A61P35/02A61P35/00
Inventor 王怀伟韩重李大成窦建民
Owner LIAOCHENG UNIV
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