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Medicinal composition for improving non-dyskinesia of Parkinson disease

A Parkinson's disease, non-exercise technology, applied in drug combinations, pharmaceutical formulas, plant raw materials, etc., can solve problems such as inconvenient access, anxiety, insomnia, nightmares and depression for patients

Active Publication Date: 2015-04-22
JILIN BAINIAN HANKE PHARM CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Drugs for the treatment of PD, such as levodopa preparations (Xining), dopamine release accelerators, most of which are likely to cause abnormal mental behaviors and other adverse reactions, the more common ones are restlessness, insomnia, nightmares and depression, etc., resulting in reduced sleep efficiency and sleep latency The more types of prolonged medication, the more likely these adverse reactions will appear
[0006] At present, there is no Chinese patent medicine that is convenient for patients to take and treat depression and sleep disorders in Parkinson's disease non-movement disorders at the same time

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0039] Example 1 A Tablet for Improving Parkinson's Disease Non-Motion Impairment

[0040] Determination method of icariin content: use liquid phase analysis method to detect the content of icariin. Take PERKIN-EIMER-SH / 5C 18 The column is an analytical column, using acetonitrile: water: 36% acetic acid (25:73.5:1.5) as the mobile phase, the flow rate is 1.0ml / min, and the UV detection wavelength is 270nm.

[0041] Weigh the reference substance W 1 g, using methanol to prepare the reference solution, the area of ​​liquid phase detection of icariin is A 1 , Weigh the sample as W 2 g, the same method is made into sample solution, the area of ​​icariin is A 2 , according to the content of icariin=A 2 ×W 1 ×100% / (A 1 ×W 2 ).

[0042] Determination method of total flavonoids in Epimedium: Determination according to Pharmacopoeia method, that is, determination by ultraviolet spectrophotometry.

[0043] Determination method of glycyrrhizic acid content: use the liquid phase...

Embodiment 2

[0057] Example 2 The effect of the tablet prepared in Example 1 on improving the depressive symptoms in Parkinson's disease non-movement disorders

[0058] 1 Materials and methods

[0059] 1.1 Research object

[0060] The diagnosis of PD is consistent with Martila's proposal that at least two of the following four classic symptoms should be present, namely, resting tremor, decreased movement, increased muscle tone, and postural reflex disturbance, excluding symptomatic PD and previous psychosis.

[0061] 1.2 Research Methods

[0062] The disease severity of PD patients was assessed by disease classification and the International Unified Outcome Standards (UPDS). For depression, the 17-item version of the Hamilton Depression Scale (HAMD) was used. 0-8 points were no depressive symptoms, and 9-16 points were mild. Depression, >17 points are divided into moderate-severe depression, ≥16 points are included in the criteria, and patients with severe cardiopulmonary, liver and kidn...

Embodiment 3

[0079] Example 3 The effect of the tablet prepared in Example 1 on improving sleep disorders in Parkinson's disease non-movement disorders

[0080] 1 Materials and methods

[0081] 1.1 Research object

[0082] General information: 60 patients with Parkinson's disease (Hoehn-Yahr grade I-V) with sleep disorders, including 34 males and 26 females. The age ranged from 45 to 83 years (62.25 ± 6.70 years), and the course of disease was 1.50 to 12.00 years (3.25 ± 2.65 years). Hoben-Yanr classification: 4 cases of grade I, 19 cases of grade II. There were 23 cases of grade III, 10 cases of grade IV, and 4 cases of grade V.

[0083] Inclusion criteria: All cases met the diagnostic criteria of the United Kingdom Parkinson Disease Society (UKPDS), showed slow onset, and had at least 2 of the 3 symptoms of resting tremor, muscle rigidity, and slow movement, and levodopa The treatment test response was positive.

[0084] Exclusion criteria: Parkinson's syndrome and Parkinson's plus ...

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PUM

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Abstract

The invention relates to a medicinal composition for improving depression and sleep disorder in non-dyskinesia of Parkinson disease. The medicinal composition comprises the following components in parts by weight: 1 to 60 parts of epimedium extract, 1 to 300 parts of common cephalanoplos herb flower aqueous extract, 1 to 300 parts of liquorice aqueous extract, and 10 to 600 parts of white paeony root alcoholic extract, wherein the epimedium extract, the liquorice aqueous extract and the white peony root alcoholic extract have the effect of inhibiting depression, while the common cephalanoplos herb flower aqueous extract has a remarkable effect for treating agrypnia. Interaction with medicaments for treating Parkinson disease, such as dopamine precursor, levodopa and a dopamine receptor stimulant, can be reduced due to the compatibility of the components, and the effects of inhibiting depression and sleep disorder can be strengthened. The composition can be produced into solid preparation and / or liquid preparation, and can be applied to preparation of medicaments for improving depression and / or sleep disorder in the non-dyskinesia of Parkinson disease.

Description

technical field [0001] The invention relates to a pharmaceutical composition for auxiliary treatment of Parkinson's disease, in particular to a pharmaceutical composition for improving non-movement disorders of Parkinson's disease. Background technique [0002] Parkinson's disease (Parkinson Disease, PD) is a chronic neurodegenerative disease, the main clinical manifestations are tremor, stiffness, bradykinesia and posture instability, the incidence rate gradually increases with the aging of the population, and PD in the elderly aged 60 and above The prevalence is about 1%. For PD, there are currently drug treatments, surgical damage to the globus pallidus, deep brain electrode burial, electrical stimulation, cell transplantation, and gene therapy. Due to the limitations of many factors, drug treatment is still the main method. The most commonly used western medicines in clinical practice are Madopar and Sinine, etc., which belong to alternative treatments. Western medicin...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K36/71A61P25/20A61P25/24A61P25/16
Inventor 苏建丽
Owner JILIN BAINIAN HANKE PHARM CO LTD