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Soft capsule containing desloratadine and preparation method thereof

A technology of desloratadine and soft capsules, which is applied in the field of medicine and can solve the problems of instability of desloratadine when it encounters oxygen, light and humidity

Active Publication Date: 2012-12-12
AVENTIS PHARMA HAINAN
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0009] The purpose of the present invention is to overcome existing technical defect, provide a kind of soft capsule of desloratadine, solve the problem that desloratadine encounters oxygen, light, the unstable problem of humidity, improve the desloratadine preparation Security and stability to function more effectively

Method used

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  • Soft capsule containing desloratadine and preparation method thereof
  • Soft capsule containing desloratadine and preparation method thereof
  • Soft capsule containing desloratadine and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0026]

[0027]

[0028] Capsule material preparation: Weigh the prescribed amount of sorbitol and water, stir evenly, add the prescribed amount of sodium methylparaben, sodium propylparaben, titanium dioxide and tartrazine, stir to mix evenly, quickly add the prescribed amount of gelatin Carry out sol, degas, and set aside.

[0029] Preparation of the contents: heat and stir the prescribed amount of beeswax and vegetable oil in the liquid preparation tank through interlayer steam until the beeswax is completely dissolved, and after cooling to room temperature, add the prescribed amount of butyl anisole (BHA) and desloratadine, Mix well and set aside.

[0030] Preparation of soft capsules: pressing pills, washing pills and drying by pressing method.

Embodiment 2

[0032]

[0033]

[0034]

[0035] Capsule material preparation: Weigh the prescribed amount of sorbitol and water, stir evenly, add the prescribed amount of sodium methylparaben, sodium propylparaben, titanium dioxide and tartrazine, stir to mix evenly, quickly add the prescribed amount of gelatin Carry out sol, degas, and set aside.

[0036] Preparation of the contents: heat and stir the prescribed amount of beeswax and vegetable oil in the liquid preparation tank through interlayer steam until the beeswax is completely dissolved, and after cooling to room temperature, add the prescribed amount of butyl anisole (BHA) and desloratadine, Mix well and set aside.

[0037] Preparation of soft capsules: pressing pills, washing pills and drying by pressing method.

Embodiment 3

[0039]

[0040]

[0041] Capsule material preparation: Weigh the prescribed amount of sorbitol and water, stir evenly, add the prescribed amount of sodium methylparaben, sodium propylparaben, titanium dioxide and tartrazine, stir to mix evenly, quickly add the prescribed amount of gelatin Carry out sol, degas, and set aside.

[0042] Preparation of the contents: heat and stir the prescribed amount of beeswax and vegetable oil in the liquid preparation tank through interlayer steam until the beeswax is completely dissolved, and after cooling to room temperature, add the prescribed amount of butyl anisole (BHA) and desloratadine, Mix well and set aside.

[0043] Preparation of soft capsules: pressing pills, washing pills and drying by pressing method.

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PUM

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Abstract

The invention belongs to the technical field of medicines and particularly relates to a soft capsule containing desloratadine and a preparation method thereof. Content of the soft capsule is prepared by esloratadine, antioxygen, dispersion media and suspending agents according to certain proportion, safety and stability of the soft capsule are improved by means of the soft capsule mode, so that the soft capsule is fast in dissolving, high in bioavailability, accurate in dose and fast in effect, the preparation method is simple, and the soft capsule is easy to produce and wide in application prospect.

Description

1. Technical field [0001] The invention relates to a pharmaceutical composition and a preparation method thereof, in particular to a desloratadine-containing soft capsule and a preparation method thereof, belonging to the technical field of medicine. 2. Background technology [0002] Desloratadine is a non-sedative long-acting tricyclic antihistamine, which is the active metabolite of loratadine, which can inhibit various allergic inflammatory chemical reactions by selectively blocking peripheral H1 receptors. The release of mediators, such as: inhibiting mast cells and basophils from releasing histamine, prostaglandins, interleukins, etc., to relieve symptoms related to allergic rhinitis or chronic idiopathic urticaria. [0003] Desloratadine is a white or off-white solid, slightly soluble in water, easily soluble in ethanol and propylene glycol. Its structure is as follows: [0004] [0005] It can be seen from the structure that desloratadine is an amine compound, an...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/48A61K31/4545A61P37/08
Inventor 马莉郭夏宋雪梅
Owner AVENTIS PHARMA HAINAN
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