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Antibacterial agent

An antibacterial agent, mass fraction technology, applied in the direction of antibacterial drugs, inorganic active ingredients, skin diseases, etc., to achieve the effect of quick effect, improved compliance and convenient use

Active Publication Date: 2013-08-14
张晋瑞
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

So far, no bacteria can escape the killing effect of ionized silver

Method used

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  • Antibacterial agent
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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0016] An antibacterial agent, especially an antibacterial agent that can promote wound healing, its 1000g formula includes: 20g of silver nitrate solution with a mass fraction of 5%, 8g of chitosan derivatives, 165g of glyceryl monostearate, Glycerin 100g, ethanol 45g, mint 8g, triethanolamine 2g, ethylparaben 1g, and the rest is purified water.

[0017] At 55°C, dissolve glycerol monostearate, mint and ethylparaben with ethanol, then add glycerin and mix well to make an organic phase; dissolve triethanolamine and chitosan derivatives with purified water, Slowly add the organic phase under stirring, stir evenly, then add a silver nitrate solution with a mass fraction of 5%, and mix well to obtain a brown cream.

[0018] Wherein the chitosan derivative is obtained by the following method:

[0019] Weigh 4.5g chitosan, add 250mL mixed solution of 0.1mol / L hydrochloric acid and 0.2mol / L sulfuric acid (the volume ratio of 0.1mol / L hydrochloric acid and 0.2mol / L sulfuric acid is ...

Embodiment 2

[0021] An antibacterial agent, especially an antibacterial agent that can promote wound healing, its 1000g formula includes: 15g of silver nitrate solution with a mass fraction of 5%, 6g of chitosan derivatives, 150g of glyceryl monostearate, Glycerin 80g, ethanol 30g, mint 5g, triethanolamine 1g, ethylparaben 0.5g, and the rest is purified water.

[0022] At 50°C, dissolve glycerol monostearate, mint and ethylparaben with ethanol, then add glycerin and mix well to make an organic phase; dissolve triethanolamine and chitosan derivatives with purified water, Then add a silver nitrate solution with a mass fraction of 5%, and finally add the organic phase slowly under stirring, stir well, and obtain a brown cream after fully mixing.

[0023] Wherein the chitosan derivative is obtained by the following method:

[0024] Weigh 3g of chitosan, add 200mL of a mixed solution of 0.1mol / L hydrochloric acid and 0.2mol / L sulfuric acid (the volume ratio of 0.1mol / L hydrochloric acid to 0.2...

Embodiment 3

[0026] An antibacterial agent, especially an antibacterial agent that can promote wound healing, its 1000g formula includes: 25g of silver nitrate solution with a mass fraction of 5%, 10g of chitosan derivatives, 180g of glyceryl monostearate, Glycerin 120g, ethanol 60g, mint 10g, triethanolamine 3g, ethylparaben 2g, and the rest is purified water.

[0027] At 60°C, dissolve glycerol monostearate, mint and ethylparaben with ethanol, then add glycerin and mix well to make an organic phase; dissolve triethanolamine and chitosan derivatives with purified water, Slowly add the organic phase under stirring, then add a silver nitrate solution with a mass fraction of 5%, and mix thoroughly to obtain a brown cream.

[0028] Wherein the chitosan derivative is obtained by the following method:

[0029] Weigh 6g of chitosan, add 300mL of a mixed solution of 0.1mol / L hydrochloric acid and 0.2mol / L sulfuric acid (the volume ratio of 0.1mol / L hydrochloric acid to 0.2mol / L sulfuric acid is ...

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Abstract

The invention provides an antibacterial agent which takes nano-silver and chitosan or derivatives of nano-silver and chitosan as active ingredients. The prepared emulsifiable paste has the functions of resisting bacteria, diminishing inflammation, relieving itching and promoting the skin surface tissue repair and trauma surface healing, and has the characteristics of quick absorption, quick acting and convenience in use, cannot cause drug resistance, and is capable of shortening the wound healing time; and moreover, the product can be stored for a long time, has not change in color, and is contributed to improvement of the compliance of a patient.

Description

technical field [0001] The invention relates to an antibacterial agent, in particular to an antibacterial agent capable of promoting wound healing. Background technique [0002] Currently commonly used trauma treatment products include: traditional Chinese medicines, chemical agents, band-aids, wound healing protective films, etc. Traditional Chinese medicines have few side effects, but are slow to take effect and take a long time to heal wounds; chemical agents are prone to drug resistance, and some are irritating, causing discomfort during use; Pay attention to waterproofing, which brings inconvenience to patients to a certain extent. [0003] Silver can block electron transport in bacteria, increase the stability of bacterial DNA and weaken bacterial cell replication. Silver can also destroy the structure and receptor function of bacteria to form insoluble and ineffective metabolic compounds, thus contributing to the prevention and treatment of infection. controlled wit...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K33/38A61P31/04A61P17/02A61K31/722
Inventor 张晋瑞
Owner 张晋瑞