Beta-aminopropionitrile consecutive reaction process

A technology of aminopropionitrile and reaction, applied in the field of synthesis of organic compounds, can solve the problems of low selectivity of β-aminopropionitrile, high content of by-products, decreased selectivity, etc., to achieve enhanced selectivity, strong reaction selectivity, Effect of Yield Improvement

Inactive Publication Date: 2012-12-19
江西兄弟医药有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0011] Above (2) (3) (4) three all adopt typical batch tank reactor to carry out, and some bibliographical reports thereafter also mainly adopt this method, and its major shortcoming is exactly the selectivity of β-aminopropionitrile Low, usually below 50%, the content of by-products is quite high, and the reaction pressure is high, there are certain potential safety hazards
[0012] In the traditional batch reaction, acrylonitrile and liquid ammonia are stirred in the kettle at the same time

Method used

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  • Beta-aminopropionitrile consecutive reaction process

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0037] Add 1500L of ammonia water with a content of 35% to the 2000L ammonia distribution kettle 1, and then add 100L of the phase transfer catalyst of the mixture of isopropanol and n-propanol configured in proportion; add 240kg of acrylonitrile into the acrylonitrile storage tank 2; Connect the ammonia water and acrylonitrile to the two inlets of the proportional pump 3 respectively, and enter the pipeline reactor 4 according to the volume ratio of ammonia water: acrylonitrile = 5:1. The ammonia water first passes through the preheating section, and then mixes with acrylonitrile and enters the reactor In the section, circulating water is used to control the temperature to ensure that the temperature of the reactor is 100-150°C and the pressure is below 1.0MPa. Ammonia, the material at the bottom of the tower is continuously transferred to the decompression ammonia flooding kettle 6 for further decompression and decompression of ammonia. After the ammonia flooding, the materia...

Embodiment 2

[0040] When testing in the laboratory, add 1500ml of ammonia water with a content of 35% to the 2000ml constant pressure funnel, and then add 100ml of the phase transfer catalyst of the mixture of isopropanol and n-propanol configured in proportion; Add 240g of acrylonitrile; connect the ammonia water and acrylonitrile to the two inlets of the proportional pump respectively, and enter the pipeline reactor according to the volume ratio of ammonia water: acrylonitrile = 5:1. The ammonia water first passes through the preheating section, and then mixes with acrylonitrile Enter the reactor section, use circulating water to control the temperature, ensure that the reactor temperature is 100-150°C, and the pressure is below 1.0MPa to react. After passing through the pipeline reactor, the material is decompressed to 0.05MPa through the pressure reducing valve and enters the ammonia removal tower In addition to ammonia, the material at the bottom of the tower is continuously transferre...

Embodiment 3

[0043]Add 750L of ammonia liquor with a content of 35% configured in the ammonia distribution kettle, then add 50L of a mixture phase transfer catalyst of isopropanol and n-propanol configured in proportion; add 120kg of acrylonitrile to acrylonitrile storage tank 2; mix ammonia liquor and Acrylonitrile is respectively connected to the two inlets of the proportional pump 3, and enters the pipeline reactor 4 according to the volume ratio of ammonia water: acrylonitrile=5:1. The ammonia water first passes through the preheating section, and then mixes with acrylonitrile and enters the reactor section. The temperature of the circulating water is controlled to ensure that the temperature of the reactor is 100-150°C and the pressure is below 1.0MPa. The material is continuously transferred to the decompression ammonia flooding kettle 6 for further decompression and ammonia flooding. After the ammonia flooding is completed, the material continuously enters the water distillation towe...

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Abstract

The invention discloses a beta-aminopropionitrile consecutive reaction process, which comprises the following steps: mixing ammonia water and a phase-transfer catalyst, reacting the ammonia water and acrylonitrile according to certain proportion under certain temperature condition, then performing ammonia removal under reduced pressure, dehydrating and removing a solvent, and then distilling to obtain the beta-aminopropionitrile. The invention employs the consecutive reaction technology, the usage of the special phase-transfer catalyst enables strong reaction selectivity, the side reaction is inhibited, and the ammonification reaction yield is substantially enhanced, simultaneously, the reaction pressure is greatly reduced, and the reaction can be completed below 1.0 MPa, thereby the safety coefficient of the reaction can be substantially increased.

Description

technical field [0001] The invention relates to a synthesis method of an organic compound, in particular to a continuous reaction process of an organic chemical intermediate β-aminopropionitrile. Background technique [0002] Nitrile compounds are a class of chemical substances (R-CN) containing cyano functional groups, and are important synthetic raw materials. Starting from nitrile compounds, a class of compounds with higher value and wider application range such as amides, amino acids, and carboxylic acids can be obtained. They can be used as chemical raw materials, pharmaceutical intermediates, and vitamin precursors. [0003] β-aminopropionitrile is an important organic chemical intermediate, which can be used as a raw material for the synthesis of alanine and pantothenic acid. It can be used to prepare 1,3-diaminopropane through hydrogenation reduction. Its most important use is to react with phosgene Preparation of isocyanates, which in turn react with p-nitroaniline...

Claims

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Application Information

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IPC IPC(8): C07C255/24C07C253/30
Inventor 李健平李来成陈英明崔胜凯
Owner 江西兄弟医药有限公司
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