Capsule containing flupirtine maleate and preparation method thereof

A technology of flupirtine maleate and capsules, which is applied in the field of medicine, can solve the problems of difficult storage, poor stability, and low dissolution rate, and achieve the effect of convenient product storage and enhanced stability

Inactive Publication Date: 2012-12-26
TIANJIN CHASE SUN PHARM CO LTD
2 Cites 3 Cited by

AI-Extracted Technical Summary

Problems solved by technology

[0005] Flupirtine maleate is easily degraded when exposed to light, and is not easy to store
Through long-term research, we have found that the currently commercially available flupirt...
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Abstract

The invention relates to a medicinal composition containing flupirtine maleate and a preparation method of the medicinal composition containing flupirtine maleate. The flupirtine maleate composition provided by the invention contains dried solid particles containing flupirtine maleate and a pharmaceutically acceptable adjuvant which is not contained in the particles. The composition is high in storage stability.

Application Domain

Nervous disorderAntipyretic +3

Technology Topic

DrugFLUPIRTINE MALEATE +3

Image

  • Capsule containing flupirtine maleate and preparation method thereof
  • Capsule containing flupirtine maleate and preparation method thereof
  • Capsule containing flupirtine maleate and preparation method thereof

Examples

  • Experimental program(5)

Example Embodiment

[0054] Example 1. The prescription of flupirtine maleate capsules:
[0055]
[0056] Process:
[0057] 1) Pass the calcium hydrogen phosphate through a 100-mesh sieve and set aside;
[0058] 2) Crush flupirtine maleate through a 600 mesh sieve for use;
[0059] 3) Mix flupirtine maleate, calcium hydrogen phosphate, 10g silicon dioxide, and 10g magnesium stearate evenly;
[0060] 4) Put the above-obtained materials in a dry granulator to make dried materials, and crush them into dry granules by a swing granulator;
[0061] 5) Pass the obtained dry particles through 24 mesh and 80 mesh stainless steel screens in sequence, and collect the upper part of the 80 mesh screen as qualified particles;
[0062] 6) Add additional auxiliary materials crospovidone, 10g silicon dioxide, 3g magnesium stearate to the above materials, and mix them evenly;
[0063] 7) Fill the capsule.

Example Embodiment

[0064] Example 2. The prescription of flupirtine maleate capsules:
[0065]
[0066] Process:
[0067] 1) Pass the calcium hydrogen phosphate through a 100-mesh sieve and set aside;
[0068] 2) Crush flupirtine maleate through a 600 mesh sieve for use;
[0069] 3) Mix flupirtine maleate with calcium hydrogen phosphate, 10g silicon dioxide, and 10g magnesium stearate.
[0070] 4) Put the material obtained above into a dry granulator to make a dried material, and crush it into dry granules by a swing granulator;
[0071] 5) Pass the obtained dry particles through 24 mesh and 80 mesh stainless steel screens in sequence, and collect the upper part of the 80 mesh screen as qualified particles;
[0072] 6) Add additional auxiliary materials crospovidone, 10g silicon dioxide, 3g magnesium stearate to the above materials, and mix well;
[0073] 7) Fill the capsule.

Example Embodiment

[0074] Example 3. The prescription of flupirtine maleate capsules:
[0075]
[0076] 1) Pass the calcium hydrogen phosphate through a 100-mesh sieve and set aside;
[0077] 2) Crush flupirtine maleate through a 600 mesh sieve for use;
[0078] 3) Mix flupirtine maleate with calcium hydrogen phosphate, 20g silicon dioxide, and 20g magnesium stearate;
[0079] 4) Put the material obtained above into a dry granulator to make a dried material, and crush it into dry granules by a swing granulator;
[0080] 5) Pass the obtained dry particles through 24 mesh and 80 mesh stainless steel screens in sequence, and collect the upper part of the 80 mesh screen as qualified particles;
[0081] 6) Add additional auxiliary materials crospovidone, 20g silicon dioxide, 6g magnesium stearate to the above materials, and mix well;
[0082] 7) Fill the capsule.

PUM

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Description & Claims & Application Information

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