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Solution for surgery and endoscope washing and preparation method thereof

A technique for irrigating liquid and solution, applied in the field of surgical and endoscopic rinsing solutions and their preparation, can solve problems such as cartilage softening, collagen swelling, iatrogenic damage to articular cartilage, etc. The effect of stability

Inactive Publication Date: 2012-12-26
北京金康驰医药投资有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, because normal saline only contains sodium chloride as a single electrolyte component, and the pH value is slightly acidic, a large amount of liquid is used for lavage in a relatively short period of time during the operation, which will change the internal environment of the joint during arthroscopic surgery, resulting in the washing of proteoglycans in the articular cartilage. Detachment, a large amount of water enters the articular cartilage to soften the cartilage and swell the collagen, which can cause iatrogenic damage to the articular cartilage
However, in official laparoscopic plasma bipolar resection, there is a large difference in the composition of normal saline and plasma electrolytes.

Method used

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  • Solution for surgery and endoscope washing and preparation method thereof
  • Solution for surgery and endoscope washing and preparation method thereof
  • Solution for surgery and endoscope washing and preparation method thereof

Examples

Experimental program
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Effect test

Embodiment 1

[0030] Example 1: Solution

[0031] 1. Raw materials: sodium chloride (NaCl) 526g, sodium acetate (C 2 h 3 NaO 2 ·3H 2 O) 368g, sodium gluconate (C 6 h 11 ·NaO 7 ) 502g, potassium chloride (KCl) 37g and magnesium chloride (MgCl 2 ·6H 2 O) 30g.

[0032] 2. Preparation method: Add 20 liters of water for injection into the concentrated preparation tank, weigh the prescribed amount of sodium chloride, sodium gluconate, sodium acetate, potassium chloride and magnesium chloride, put them in the concentrated preparation tank, and put them in after stirring and dissolving 0.1% (g / mL) activated carbon for needles, boil for 15 minutes, stir well, let it stand for adsorption for 15 minutes, cool to 60°C, pass through a 5μm titanium rod for decarbonization and circulation for 15 minutes, and then inject it through a titanium rod and a 0.45μm filter element Dilute cans. Add water for injection to 100 liters in the dilute preparation tank, stir and circulate for 15 minutes, adjust...

Embodiment 2

[0033] Example 2: Solution

[0034] 1. Raw materials: sodium chloride (NaCl) 526g, sodium acetate (C 2 h 3 NaO 2 ·3H 2O) 368g, sodium gluconate (C 6 h 11 ·NaO 7 ) 502g, potassium chloride (KCl) 37g and magnesium chloride (MgCl 2 ·6H 2 O) 30g.

[0035] 2. Preparation method: Add 20 liters of water for injection into the concentrated preparation tank, weigh the prescribed amount of sodium chloride, sodium gluconate, sodium acetate, potassium chloride and magnesium chloride, put them in the concentrated preparation tank, and put them in after stirring and dissolving 0.1% (g / mL) activated carbon for needles, boil for 15 minutes, stir well, let it stand for adsorption for 15 minutes, cool to 60°C, pass through a 5μm titanium rod for decarbonization and circulation for 15 minutes, and then inject it through a titanium rod and a 0.45μm filter element Dilute cans. Add water for injection to 100 liters in the dilute preparation tank, stir and circulate for 20 minutes, adjust ...

Embodiment 3

[0036] Example 3: Solution

[0037] 1. Raw materials: sodium chloride (NaCl) 526g, sodium acetate (C 2 h 3 NaO 2 ·3H 2 O) 368g, sodium gluconate (C 6 h 11 ·NaO 7 ) 502g, potassium chloride (KCl) 37g and magnesium chloride (MgCl 2 ·6H 2 O) 30g.

[0038] 2. Preparation method: Add 20 liters of water for injection into the concentrated preparation tank, weigh the prescribed amount of sodium chloride, sodium gluconate, sodium acetate, potassium chloride and magnesium chloride, put them in the concentrated preparation tank, and put them into the concentrated preparation tank after stirring and dissolving 0.1% (g / mL) activated carbon for needles, boil for 15 minutes, stir well, let it stand for adsorption for 15 minutes, cool to 60°C, pass through a 5μm titanium rod for decarbonization and circulation for 15 minutes, and then inject it through a titanium rod and a 0.45μm filter element Dilute cans. Add water for injection to 100 liters in the dilute preparation tank, stir ...

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Abstract

The invention relates to a solution for surgery and endoscope washing and a preparation method of the solution. Each 100mL of the solution contains 526mg of sodium chloride, 368mg of sodium acetate, 502mg of sodium gluconate, 37mg of potassium chloride and 30mg of magnesium chloride; and the pH value of the solution is 6.7 to 7.2 and the osmotic pressure is 280 to 300mOsmol / kg. The production process of the solution provided by the invention is managed according to the relevant quality standards of an injection, and the bacterial endotoxins and the insoluble particles completely accord with the requirements of the injection; and moreover, the polypropylene infusion bottles are served as an inner packing material, the contents and the packing material have good biocompatibility, so that the solution is convenient for clinical use and transportation and storage.

Description

technical field [0001] The invention relates to the field of pharmaceutical preparations, in particular to a solution for surgery and laparoscopic flushing and a preparation method thereof. Background technique [0002] Various operations under arthroscopy, gynecological laparoscopy, transurethral resection of the prostate, pneumatic lithotripsy under ureteroscopy, and laparoscopy all require continuous perfusion of sterile liquid with a certain pressure and flow rate to achieve flushing. , dilation and clear vision. Whether a certain amount of sterile fluid can be perfused continuously as needed is one of the important prerequisites for the success of the operation. In addition, the flushing fluid can also be used as a carrier for drugs such as antibiotics, thereby preventing infection and reducing postoperative complications. It has been proven that the amount of flushing fluid entering the systemic circulation is relatively large. Therefore, these flushing fluids must b...

Claims

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Application Information

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IPC IPC(8): A61K33/14A61K9/08A61P41/00A61K31/19A61K31/191
Inventor 刘向荣杨惠超
Owner 北京金康驰医药投资有限公司
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