Iron protein succinylate oral solution and preparation method thereof

A technology of iron protein succinate and oral solution, which is applied in the field of medicine to achieve the effects of stable quality, good taste and good solubility

Active Publication Date: 2014-06-25
JUMPCAN PHARMA GRP
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

At present, there are few studies on the dosage form of iron protein succinate, so it is necessary for the public to provide an oral solution of iron protein succinate with good taste, convenient administration and good compliance

Method used

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  • Iron protein succinylate oral solution and preparation method thereof
  • Iron protein succinylate oral solution and preparation method thereof
  • Iron protein succinylate oral solution and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0030] A kind of ferric protein succinate oral solution, it is prepared by following method:

[0031] 1) Weigh 45 grams of iron protein succinate, add 600ml of purified water and stir, adjust the pH value to about 6.0 with 4mol / L sodium hydroxide solution, and fully stir to dissolve;

[0032] 2) Weigh 50 grams of sorbitol, 1 gram of sodium methylparaben (sodium methylparaben), 0.1 grams of sodium propylparaben (sodium propylparaben) and 2.5 grams of stevia, and use 100ml Dissolve in water (60°C), add to the above solution after complete dissolution;

[0033] 3) Add 20 grams of propylene glycol and 4.0 grams of orange essence, stir evenly, adjust the pH value to 7.2-7.4 with 4mol / L sodium hydroxide solution, add purified water to make the volume to 1L, stir well, and filter;

[0034] 4) Detect the pH value and iron content. After passing the test, fill it, add a Seza cover, and sterilize at 100°C for 30 minutes;

[0035] 5) Subpackaging in units of 15ml to obtain the iron pro...

Embodiment 2

[0037] A kind of ferric protein succinate oral solution, it is prepared by following method:

[0038] 1) Weigh 65 grams of iron protein succinate, add 600ml of purified water and stir, adjust the pH value to about 6.0 with 4mol / L sodium hydroxide solution, heat to 65°C, and fully stir to dissolve;

[0039] 2) Weigh 120 grams of sorbitol, 10 grams of sodium methylparaben (sodium methylparaben), 3 grams of sodium propylparaben (sodium propylparaben) and 10 grams of stevia, and use 100ml Dissolve in water (60°C), add to the above solution after complete dissolution;

[0040] 3) Add 100 grams of propylene glycol and 10 grams of orange essence, stir evenly, adjust the pH value to 7.2-7.4 with 4mol / L sodium hydroxide solution, add purified water to make the volume to 1L, stir well, and filter;

[0041] 4) Detect the pH value and iron content. After passing the test, fill it, add a Seza cover, and sterilize at 100°C for 30 minutes;

[0042] 5) Subpackaging in units of 15ml to obtai...

Embodiment 3

[0044] A kind of ferric protein succinate oral solution, it is prepared by following method:

[0045] 55.3 grams of iron protein succinate, 93.3 grams of sorbitol, 66.7 grams of propylene glycol, 3.0 grams of sodium methylparaben, 1.0 grams of sodium propylparaben, 2.5 grams of stevia, 4.0 grams of orange flavor, appropriate amount of sodium hydroxide , after dissolving, dilute to 1000 ml with purified water.

[0046] 1) Weigh 55.3 grams of iron protein succinate, add 600ml of purified water and stir, adjust the pH value to about 6.0 with 4mol / L sodium hydroxide solution, and fully stir to dissolve;

[0047] 2) Weigh 93.3 grams of sorbitol, 3.0 grams of sodium methylparaben (sodium methylparaben), 1.0 grams of sodium propylparaben (sodium propylparaben) and 2.5 grams of stevia, and use 100ml Dissolve in water (60°C), add to the above solution after complete dissolution;

[0048]3) Add 66.7 grams of propylene glycol and 4.0 grams of orange essence, stir evenly, adjust the pH ...

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Abstract

The invention belongs to the technical field of medicines and in particular relates to iron protein succinylate oral solution and a preparation method thereof. The oral solution is obtained by dissolving 45-65g of iron protein succinylate, 50-120g of sorbitol, 20-100g of propylene glycol, 1-10g of sodium methyl parahydroxybenzoate, 0.1-3.0g of sodium propyl parahydroxybenzoate, 1-10g of sodium cyclamate, 1-10g of orange essence and defined amount of sodium hydroxide and then metering the volume to 1000ml with purified water. The oral solution has good taste and good compliance and is convenient to take. The preparation method has the advantages of simpleness in operation and no need for special equipment.

Description

technical field [0001] The invention belongs to the technical field of medicines, in particular to a ferric protein succinate oral solution and a preparation method thereof. Background technique [0002] Anemia refers to the pathological phenomenon that the number of red blood cells or hemoglobin in the circulating blood is lower than the normal value for a long time. Usually anemia is divided into three categories: iron deficiency anemia (iron deficiency aneima, IDA), megaloblastic anemia and aplastic anemia. Iron-deficiency anemia is mainly caused by blood loss or insufficient iron absorption, such as chronic hemorrhagic anemia such as female menorrhagia, peptic ulcers, and hemorrhoids, and iron-deficiency anemia such as malnutrition, pregnancy, and growing children. [0003] Along with the raising of people's living standard at present, broad masses of the people pay more and more attention to health. In order to prevent and control iron deficiency anemia, various appro...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K38/17A61K9/08A61P7/06
Inventor 曹龙祥董自波夏立武杭夏清邵建国
Owner JUMPCAN PHARMA GRP
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