Compositions and methods for enhancing proteasome activity

A compound and hydrate technology, applied in the field of compositions and methods for improving proteasome activity, can solve problems such as affecting the degradation rate of substrates
CN102844313AInactive Publication Date: 2012-12-26PRESIDENT & FELLOWS OF HARVARD COLLEGE
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Patent Information

Authority / Receiving Office
CN · China
Current Assignee / Owner
PRESIDENT & FELLOWS OF HARVARD COLLEGE
Publication Date
2012-12-26
Estimated Expiration
Not applicable · inactive patent

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Abstract

Proteinopathies result from the proteasome not acting efficiently enough to eliminate harmful proteins and prevent the formation of the pathogenic aggregates. As described herein, inhibition of proteasome-associated deubiquitinase Usp 14 results in increased proteasome efficiency. The present invention therefore provides novel compositions and methods for inhibition of Uspl4, enhancement of proteasome activity and treatment of proteinopathies.
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Description

[0001] related application

[0002] This application claims the benefit of U.S. Provisional Patent Application No. 61 / 373,404, filed August 13, 2010, and U.S. Provisional Patent Application No. 61 / 336,959, filed January 28, 2010, both of which are hereby incorporated by reference in their entirety enter.

[0003] governmental support

[0004] This invention was made with US Government support under Grant Nos. GM065592, GM66492 and DK082906 from the National Institutes of Health. The US Government has certain rights in this invention. Background technique

[0005] The proteasome is a large protein complex containing 33 different subunits. The proteasome complex acts as a protease that partially degrades unwanted or misfolded proteins. Proteasome can regulate many aspects of cell physiology, and its dysfunction can cause various diseases, including cancer and neurodegenerative diseases (Finley D., (2009), Annu.Rev.Biochem., 78,477-513; Hoeller and Dikic, (2009), Nature, 458...

Claims

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