Unlock instant, AI-driven research and patent intelligence for your innovation.

Preparation method of Astragalus mongholicus-toad oral colon targeting tablets for treating colorectal carcinoma

A colon targeting and colon cancer technology, which can be used in medical preparations containing active ingredients, pharmaceutical formulations, and medical raw materials derived from amphibians, etc., and can solve the problems of limited varieties of Chinese medicines and Chinese medicine compound preparations on the market.

Active Publication Date: 2013-01-02
ZHEJIANG CHINESE MEDICAL UNIVERSITY
View PDF0 Cites 0 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Nowadays, the research and development of colon-targeted preparations using Western medicines as raw materials is quite common, but the marketed varieties of traditional Chinese medicines and traditional Chinese medicine compound preparations are very limited

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • Preparation method of Astragalus mongholicus-toad oral colon targeting tablets for treating colorectal carcinoma
  • Preparation method of Astragalus mongholicus-toad oral colon targeting tablets for treating colorectal carcinoma
  • Preparation method of Astragalus mongholicus-toad oral colon targeting tablets for treating colorectal carcinoma

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0036] Embodiment 1: the preparation of mixed extract

[0037] Radix Astragali 15g, add 6 times of 80% ethanol and carry out reflux extraction, extract 3 times, each time 1.5 hours, combine ethanol extract to obtain extract A, extract A recovers ethanol to have no alcohol taste, concentrates to the solid-liquid ratio is 1: 0.5, to obtain the concentrated solution of astragalus alcohol extraction;

[0038] Add 10 times of water to 12g of raw rehmannia and astragalus dregs, decoct 3 times, 1.5 hours each time, combine the water extracts to obtain extract B, add ethanol to the extract B after concentration, so that the alcohol content reaches 50%, and let it stand After 24 hours, filter with suction to obtain crude polysaccharide Ⅰ. After wiping off ethanol, add water until the ratio of medicine to liquid is 1:1, then add ethanol to make the alcohol content reach 50%. After standing for 24 hours, filter with suction to obtain crude polysaccharide II;

[0039] Dried toad skin 9g...

Embodiment 2

[0044] Embodiment 2: the preparation of mixed extract

[0045] Astragalus 12g plus 10 times 90% ethanol for reflux extraction, extraction 2 times, 1 hour each time, combined ethanol extract to obtain extract A, extract A was recovered from ethanol until it had no alcohol smell, and concentrated until the ratio of solid to liquid was 1:1 , to obtain the concentrated solution of astragalus alcohol extraction;

[0046] Add 8 times of water to 6g of raw land and astragalus dregs, decoct twice for 2 hours each time, combine the water extracts to obtain extract B, add ethanol to the extract B after concentration, so that the alcohol content reaches 60%, and let it stand After 48 hours, filter with suction to obtain crude polysaccharide Ⅰ. After wiping off ethanol, add water to a liquid ratio of 1:0.5, then add ethanol to make the alcohol content reach 60%. After standing still for 48 hours, filter with suction to obtain crude polysaccharide II;

[0047] Add 10 times 80% ethanol to...

Embodiment 3

[0052] Embodiment 3: the preparation of mixed extract

[0053] Astragalus membranaceus 30g plus 8 times 70% ethanol for reflux extraction, extraction 2 times, 1.5 hours each time, combined ethanol extract to obtain extract A, extract A was recovered from ethanol until it had no alcohol smell, and concentrated to a solid-liquid ratio of 1:0.8 , to obtain the concentrated solution of astragalus alcohol extraction;

[0054] Add 6 times of water to 15g of raw land and astragalus dregs, decoct 3 times, 2 hours each time, combine the water extracts to obtain extract B, add ethanol to the extract B after concentration, so that the alcohol content reaches 70%, and let it stand After 24 hours, filter with suction to obtain crude polysaccharide Ⅰ. After wiping off ethanol, add water until the ratio of medicine to liquid is 1:1, then add ethanol to make the alcohol content reach 70%. After standing for 24 hours, filter with suction to obtain crude polysaccharide II;

[0055] Add 3g of ...

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

PUM

No PUM Login to View More

Abstract

The invention discloses a preparation method of Astragalus mongholicus-toad oral colon targeting tablets for treating colorectal carcinoma, belonging to the technical field of traditional Chinese medicine preparation, comprising the following steps: 1) weighing Astragalus mongholicus, dried radix rehmanniae, dried toad skin and sophora flavescens according to the ratio of the prescription; 2) respectively extracting the effective portion of each raw medical material, and mixing the extracted effective portions to obtain a mixed extract; 3) weighing the mixed extract, a filler and a glidant, adding the filler in the mixed extract, uniformly mixing, granulating by wet process to obtain wet particles, drying, and conducting granulation to obtain dry particles, then adding the glidant, and tabletting to obtain Astragalus mongholicus-toad plain tablets; and 4) weighing a film forming agent, a plasticizer and an antiadherent to obtain a coating liquid, coating the Astragalus mongholicus-toad plain tablets to obtain pH-dependent Astragalus mongholicus-toad oral colon targeting tablets or pH-time lag combined Astragalus mongholicus-toad oral colon targeting tablets for treating colorectal carcinoma. The technology disclosed herein is feasible, has the effects of raising body immunity function, resisting tumor, and reducing toxic and side effect, and can provide a reference basis for screening a clinic safe dosage.

Description

technical field [0001] The invention belongs to the technical field of traditional Chinese medicine preparations, and in particular relates to a preparation method of Qichan oral colon targeting tablet for treating colon cancer. Background technique [0002] Colon cancer (carcinoma of colon) is a common malignant tumor of the digestive tract, which can occur in any part of the colon, and the sigmoid colon is the most common. According to the world epidemiological survey, colon cancer has the highest incidence rate in North America, Western Europe, Australia, New Zealand and other places, ranking the top two or three among malignant tumors. In my country, according to the latest research data, the incidence and mortality of colorectal cancer are increasing year by year, especially in some big cities, the incidence of colorectal cancer is rising rapidly, such as Shanghai, the incidence of colorectal cancer has increased from earlier The incidence rate of lung cancer has risen ...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

Application Information

Patent Timeline
no application Login to View More
IPC IPC(8): A61K36/804A61K9/32A61K9/36A61P1/00A61P35/00A61K35/56A61K35/65
Inventor 宋霄宏昝日增胡万杨黄玉叶余跃田港张小燕
Owner ZHEJIANG CHINESE MEDICAL UNIVERSITY