Traditional Chinese medicine composition for resisting ovarian failure and application thereof

A technology of ovarian function and composition, which is applied in the field of traditional Chinese medicine composition for anti-ovarian function decline, can solve problems such as clinical application limitations, achieve a large market advantage, expand the scope of application, and achieve the effect of huge market potential

Active Publication Date: 2013-01-02
南京美福天然药物科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] Hormone replacement therapy (HRT) is an important method in the treatment of ovarian aging-related symptoms and diseases in modern medicine, but existing studies have clearly shown that it has a variety of side effects and long-term carcinogenicity, which limits its clinical application.

Method used

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  • Traditional Chinese medicine composition for resisting ovarian failure and application thereof
  • Traditional Chinese medicine composition for resisting ovarian failure and application thereof
  • Traditional Chinese medicine composition for resisting ovarian failure and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0034] Get 100 kilograms of dodder, 50 kilograms of medlar, 40 kilograms of mulberry, 30 kilograms of rehmannia glutinosa and 8 kilograms of safflower, and pulverize them with a pulverizer to obtain their powder, and the number of meshes is controlled at 80 meshes. Mix the above-mentioned powdery dodder, medlar, mulberry, rehmannia glutinosa and safflower with 20,000 kg of ethanol solution with a concentration of 70% and a pH value of 6, and stir evenly in a mixer, then slowly flow into the container through a pipeline, and in the pipeline There is an ultrasonic generator on the wall of the pipe, and he performs ultrasonic vibration and crushing on the slow-flowing mixture in the pipe. The processing time is 30 minutes, so that the active ingredients in the original cells are fully dissolved into the ethanol solution. Filter the mixture solution after the ultrasonic treatment to remove the residue, and obtain about 20000 kg of the crude product solution of the Chinese patent me...

Embodiment 2

[0036] Get 200 kilograms of dodder, 100 kilograms of medlar, 80 kilograms of mulberry, 70 kilograms of rehmannia glutinosa and 20 kilograms of safflower, and pulverize them with a pulverizer to obtain their powders, and the number of meshes is controlled at 20 meshes. Mix the above-mentioned powdery dodder, medlar, mulberry, rehmannia glutinosa and safflower with 5000 kg of ethanol solution with a concentration of 75% and a pH value of 6.3, and stir evenly in a stirrer, and then heat and reflux for 12 hours to make the original cells The active ingredient in is fully dissolved in ethanol solution. The residue was filtered off to obtain a crude product solution of about 4500 kilograms of Chinese patent medicine of the present invention. Put the above-mentioned crude product solution in a vacuum desiccator, carry out low-temperature vacuum drying at -20°C, take it out after drying for 48 hours, and obtain about 56.4 kg of dry extract of the Chinese patent medicine of the present...

Embodiment 3

[0038] Get 400 kilograms of dodder, 200 kilograms of medlar, 150 kilograms of mulberries, 120 kilograms of rehmannia glutinosa and 31 kilograms of safflower, and pulverize them with a pulverizer to obtain their powders, and the number of meshes is controlled at 20 meshes. Mix the above-mentioned powdery dodder, wolfberry, mulberry, rehmannia glutinosa and safflower with 10000 kg of ethanol solution with a concentration of 80% and a pH value of 5.8, and stir evenly in a blender, and then heat and reflux for 12 hours to make the original cells The active ingredient in is fully dissolved in ethanol solution. The residue was filtered off to obtain a crude product solution of about 9000 kilograms of Chinese patent medicine of the present invention. Put the above crude product solution in a vacuum desiccator, carry out low-temperature vacuum drying at -20°C, take it out after drying for 48 hours, and obtain about 100 kg of dry extract of the Chinese patent medicine of the present in...

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Abstract

The invention belongs to the field of traditional Chinese medicine, and discloses a traditional Chinese medicine composition for resisting ovarian failure and application thereof. The traditional Chinese medicine composition for resisting ovarian failure mainly comprises 30 to 70% of cuscuta chinensis, 10 to 50% of fructus lycii, 4 to 20% of mulberry, 10 to 20% of radix rehmanniae recen, and 1 to 10% of flowers carthami. The Chinese patent medicine for resisting ovarian failure prepared from such composition can be applied to preparing the medicine for resisting ovarian failure; the ovarian failure symptoms are preferably shown as polycystic ovarian syndrome, functional abnormal menstruation, premature ovarian failure or climacteric syndrome. As the results shown, the traditional Chinese medicine composition for resisting ovarian failure is obvious in effect of generating on separated ovarian granular cells, and has the capacity of obviously improving progestogen secretion level of the separated ovarian granular cells, obviously improving the anti-apoptosis effect of the separated ovarian granular cells, reducing the levels of FSH (Follicle-Stimulating Hormone), LH (Luteinizing Hormone) and T (Triiodothyronine) of a model mice with the polycystic ovarian syndrome, and adjusting the sex hormone of a rate subjected to premature ovarian failure caused by cyclophosphamide.

Description

technical field [0001] The invention belongs to the field of traditional Chinese medicine, and relates to a traditional Chinese medicine composition for resisting ovarian function decline and its application. Background technique [0002] Ovarian function decline can lead to a series of diseases such as infertility, reproductive system, cardiovascular system, and osteoporosis. Premature ovarian failure (POF, namely premature ovarian failure) leads to a decline in the quality of life of patients. In addition, with the development of society and economy, more and more professional women choose to delay their childbearing time, but the optimal reproductive time window for women is also severely limited by ovarian function. Therefore, exploring the aging mechanism of ovarian function decline, the indicators for predicting ovarian function decline, and the measures to prevent premature ovarian function decline are the research hotspots and difficulties in the field of reproductiv...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/815A61P15/00A61P15/12
Inventor 吕晔马红韦敏
Owner 南京美福天然药物科技有限公司
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