Medicine composition with effects of clearing heat, purging fire, removing toxin, removing stasis, cooling blood, and stopping bleeding and preparation method thereof

A technology for cooling blood, stopping bleeding, clearing away heat and purging fire, which is applied in the direction of drug combinations, pharmaceutical formulas, medical preparations containing active ingredients, etc., to achieve the effects of simple extraction process, reducing the content of other inactive substances, and reducing production processes and working hours

Active Publication Date: 2013-01-16
CHENGDU KANGHONG PHARMA CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Based on this calculation, the extraction rate of the active ingredient baicalin in Yiqing capsule Scutellaria baicalensis is only about 40%, and the extraction rate of the active ingredients emodin and chrysophanol in rhubarb is only about 5%.

Method used

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  • Medicine composition with effects of clearing heat, purging fire, removing toxin, removing stasis, cooling blood, and stopping bleeding and preparation method thereof
  • Medicine composition with effects of clearing heat, purging fire, removing toxin, removing stasis, cooling blood, and stopping bleeding and preparation method thereof
  • Medicine composition with effects of clearing heat, purging fire, removing toxin, removing stasis, cooling blood, and stopping bleeding and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0059] Cut 660g of Coptis chinensis, 2000g of rhubarb and 1000g of Scutellaria baicalensis into 3000-7000mm lengths, add water to decoct twice, add 8 times of water for 3 hours for the first time, add 6 times of water for 1 hour for the second time, and combine the decoctions , filtered, the filtrate was concentrated under reduced pressure, and spray-dried to obtain Scutellaria baicalensis extract powder and mixed extract powder of Rhubarb and Coptis chinensis. The two kinds of extract powder were respectively granulated, dried, pulverized, added with appropriate amount of starch, talc and magnesium stearate, mixed well, put into capsules (0.5g per capsule), and a total of 1170 capsules were obtained. Among them, each capsule requires 0.56g of Coptis chinensis, 1.71g of Rhubarb, and 0.85g of Scutellaria baicalensis.

Embodiment 2

[0061] 660g of Coptis chinensis, 2000g of rhubarb, and 1000g of Scutellaria baicalensis were crushed to 0.8-1000 mm, and extracted twice by adding water. The first time was 12 times the amount of water for 1 hour at 80°C, and the second time, 10 times the amount of water was added to extract at 80°C for 3 hours, and the extracts were combined. , filtered, the filtrate was concentrated under reduced pressure, and spray-dried to obtain Scutellaria baicalensis extract powder and mixed extract powder of Rhubarb and Coptis chinensis. The two kinds of extract powder were respectively granulated, dried, pulverized, added with appropriate amount of starch, talc and magnesium stearate, mixed well, put into capsules (0.5g per capsule), and a total of 1422 capsules were obtained. Among them, each capsule requires 0.46g of Coptis chinensis, 1.41g of Rhubarb, and 0.70g of Scutellaria baicalensis.

Embodiment 3

[0063] Pulverize 660g of Coptis chinensis, 2000g of rhubarb and 1000g of Scutellaria baicalensis to 0.80-500mm, place them in equipment that can be concentrated at the same time of extraction, add 12 times the amount of water, extract at 80°C for 4 hours, concentrate while extracting, and concentrate evaporated. The aqueous liquid is condensed and returned to the extraction solution, the filtrate is concentrated under reduced pressure respectively, the Scutellaria baicalensis concentrate is dried to obtain Scutellaria baicalensis extract powder, the rhubarb and Coptis chinensis concentrates are combined and mixed, and dried to obtain the mixed extract powder of Coptis chinensis and rhubarb. The two kinds of extract powder were respectively granulated, dried, pulverized, added with appropriate amount of starch, talc and magnesium stearate, mixed evenly and filled into capsules (0.5g per capsule), a total of 1821 capsules were obtained. One capsule requires 0.36g of Coptis chinen...

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Abstract

The invention relates to a medicine composition with the effects of clearing heat, purging fire, removing toxin, removing stasis, cooling blood, and stopping bleeding and a preparation method thereof. According to the invention, the medicine formulation is obtained by studying and redeveloping based on the formulation of existing Yiqing capsules, thus the amount of medicinal materials is greatly reduced without reducing and even raising the curative effect of the medicine, and the medicinal material resources are saved by an average of 15-45%.

Description

technical field [0001] The invention relates to a traditional Chinese medicinal composition and a preparation method thereof, in particular to a medicinal composition for clearing heat, purging fire, detoxifying, removing blood stasis, cooling blood and stopping bleeding and a preparation method thereof. Background technique [0002] Developed from the "Xiexin Decoction" in the famous medical book "Synopsis of the Golden Chamber" in the Han Dynasty, its formula is composed of rhubarb, scutellaria baicalensis, and Coptis chinensis. , hematemesis, epistaxis, constipation and redness; accumulation of heat in the triple energizer, red and swollen eyes, sore mouth and tongue, external syndrome sores, dysphoria in the heart and chest, constipation in stool; jaundice due to damp heat, dysphoria and fullness in the chest, yellow and greasy coating on the tongue, rapid and rapid pulse By. Yiqing Capsules and Granules are developed according to the Han Dynasty prescription, and the f...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/718A61P1/02A61P1/10A61P11/04A61P7/04A61P27/02
Inventor 柯尊洪郑强滕传震
Owner CHENGDU KANGHONG PHARMA CO LTD
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