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Medicine composition with effects of clearing heat, purging fire, removing toxin, removing stasis, cooling blood, and stopping bleeding and preparation method thereof

A technology that cools blood, stops bleeding, clears away heat and relieves fire, and is applied in drug combinations, pharmaceutical formulas, medical preparations containing active ingredients, etc., to achieve the effects of reducing production processes and working hours, increasing extraction rates, and ensuring safety and effectiveness

Active Publication Date: 2014-07-23
CHENGDU KANGHONG PHARMA CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Based on this calculation, the extraction rate of the active ingredient baicalin in Yiqing capsule Scutellaria baicalensis is only about 40%, and the extraction rate of the active ingredients emodin and chrysophanol in rhubarb is only about 5%.

Method used

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  • Medicine composition with effects of clearing heat, purging fire, removing toxin, removing stasis, cooling blood, and stopping bleeding and preparation method thereof
  • Medicine composition with effects of clearing heat, purging fire, removing toxin, removing stasis, cooling blood, and stopping bleeding and preparation method thereof
  • Medicine composition with effects of clearing heat, purging fire, removing toxin, removing stasis, cooling blood, and stopping bleeding and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0058] Cut 660g of Coptis chinensis, 2000g of rhubarb, and 1000g of Scutellaria baicalensis into 3000-7000mm, add water to decoct twice, add 8 times of water for the first time and decoct for 3 hours, add 6 times of water for the second time and decoct for 1 hour, and combine the decoction , filtered, and the filtrate was concentrated under reduced pressure and spray-dried to obtain the extract powder of Scutellaria baicalensis and the mixed extract powder of rhubarb and rhubarb. The two extract powders were granulated separately, dried, crushed, added appropriate amount of starch, talcum powder and magnesium stearate, mixed evenly, packed into capsules (0.5g per capsule), and a total of 1170 capsules were obtained. After calculation, Each capsule requires 0.56g of Coptis rhizome, 1.71g of rhubarb, and 0.85g of Scutellaria baicalensis.

Embodiment 2

[0060] Crush 660g of Coptidis rhizome, 2000g of rhubarb and 1000g of Scutellaria baicalensis to 0.8-1000mm, add water to extract twice, add 12 times of water for the first time, extract at 80°C for 1 hour, add 10 times of water for the second time, extract at 80°C for 3 hours, and combine the extracts , filtered, and the filtrate was concentrated under reduced pressure and spray-dried to obtain the extract powder of Scutellaria baicalensis and the mixed extract powder of rhubarb and rhubarb. The two extract powders were granulated separately, dried, crushed, added appropriate amount of starch, talcum powder and magnesium stearate, mixed evenly, packed into capsules (0.5g per capsule), and a total of 1422 capsules were obtained. After calculation, Among them, each capsule needs 0.46g of coptis, 1.41g of rhubarb, and 0.70g of skullcap.

Embodiment 3

[0062] Crush 660g of Coptidis rhizome, 2000g of rhubarb, and 1000g of baicalin to 0.80-500mm, place them respectively in equipment capable of concentrating while extracting, add 12 times the amount of water, extract at 80°C for 4 hours, concentrate while extracting, concentrate and evaporate The water liquid is condensed and then flowed back into the extraction solution, the filtrates are respectively concentrated under reduced pressure, the Scutellaria baicalensis concentrate is dried to obtain Scutellaria baicalensis extract powder, the rhubarb and Coptidis rhizome concentrates are combined and mixed, and dried to obtain a mixed extract powder of Coptis chinensis and rhubarb. The two extract powders were made into granules respectively, dried, crushed, added appropriate amount of starch, talcum powder and magnesium stearate, mixed evenly and packed into capsules (0.5g per capsule), and a total of 1821 capsules were obtained. Capsules require 0.36g of rhubarb, 1.10g of rhubarb...

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Abstract

The invention relates to a pharmaceutical composition for clearing heat, purging fire, detoxifying, removing blood stasis, cooling blood and stopping bleeding and a preparation method thereof. The medicine prescription of the invention is based on the original prescription of Yiqing Capsules, and is redeveloped through research to ensure that the curative effect of the medicine is not reduced or even reduced. Under the premise of the improvement, the dosage of medicinal materials is greatly reduced, and an average of 15-45% of medicinal material resources is saved.

Description

technical field [0001] The invention relates to a traditional Chinese medicinal composition and a preparation method thereof, in particular to a medicinal composition for clearing heat, purging fire, detoxifying, removing blood stasis, cooling blood and stopping bleeding and a preparation method thereof. Background technique [0002] Developed from the "Xiexin Decoction" in the famous medical book "Synopsis of the Golden Chamber" in the Han Dynasty, its formula is composed of rhubarb, scutellaria baicalensis, and Coptis chinensis. , hematemesis, epistaxis, constipation and redness; accumulation of heat in the triple energizer, red and swollen eyes, sore mouth and tongue, external syndrome sores, dysphoria in the heart and chest, constipation in stool; jaundice due to damp heat, dysphoria and fullness in the chest, yellow and greasy coating on the tongue, rapid and rapid pulse By. Yiqing Capsules and Granules are developed according to the Han Dynasty prescription, and the f...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K36/718A61P1/02A61P1/10A61P11/04A61P7/04A61P27/02
Inventor 柯尊洪郑强滕传震
Owner CHENGDU KANGHONG PHARMA CO LTD