2,3-dioxyethyl-5-methyl-8,9-dimethoxy benzophenanthridine derivative, and preparation method and application thereof

A technology of dimethoxytriphenanthridine and dioxyethyl is applied in the field of preparing anti-tumor pharmaceutical compositions, which can solve the problem of low tumor cell selectivity and achieve good anti-tumor activity and significant cytotoxic activity Effect
CN102887904AInactive Publication Date: 2013-01-23GUANGXI NORMAL UNIV
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Patent Information

Authority / Receiving Office
CN · China
Patent Type
Applications(China)
Current Assignee / Owner
GUANGXI NORMAL UNIV
Publication Date
2013-01-23
Estimated Expiration
Not applicable · inactive patent

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Abstract

The invention relates to a 2,3-dioxyethyl-5-methyl-8,9-dimethoxy benzophenanthridine derivative disclosed as Formula I, a synthesis method and application thereof in preparing medicines for inhibiting tumor cell activity. The 50% inhibition concentrations IC50 of the 2,3-dioxyethyl-5-methyl-8,9-dimethoxy benzophenanthridine-hydrochloride and hydrobromide for four cancer cell strains of stomach cancer (MGC-803), liver cancer (BEL7402), human nasopharyngeal carcinoma (CNE) and human lung adenocarcinoma (A549) are respectively lower than those of nitidine chloride, and are much lower than those of 5-FU (control drug).
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Description

technical field

[0001] The present invention relates to 2,3-dioxoethyl-5-methyl-8,9-dimethoxybenzophenanthridine derivatives, a preparation method thereof, and an anti-tumor pharmaceutical composition containing the above substances . Background technique

[0002] Tumor is a common and frequently-occurring disease that seriously threatens human health. It is one of the most important diseases that endanger human life at present, and its death has ranked first among various causes of death. Among the three major therapies for malignant tumors, drug therapy occupies an important position. Most of the synthetic chemical anti-tumor drugs are compounds with natural anti-tumor active ingredients as the lead. Finding anti-tumor lead products from natural products and carrying out structural modification to make them new anti-tumor drugs is the current anti-tumor research. hotspots (Chinese Oncology, 2007, 16(9), 705-708). It has been found that current anticancer drugs generally...

Claims

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