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Use of 5'-AMP in septicemia treatment

A sepsis and application technology, applied in the application field of 5'-AMP for the treatment of sepsis, can solve the problem of undetected sepsis and achieve the effect of reducing infiltration

Inactive Publication Date: 2013-01-30
王云龙 +2
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  • Summary
  • Abstract
  • Description
  • Claims
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AI Technical Summary

Problems solved by technology

[0007] 5'-AMP is the English alias of 5'-adenosine, and its Chinese aliases also include adenosine-5'-phosphate (+4°C), adenosine 5'-phosphate, 5'-phosphate adenosine, 5'- Adenosine-phosphate, etc., so far no report on the use of 5'-AMP for the treatment of sepsis has been found

Method used

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  • Use of 5'-AMP in septicemia treatment
  • Use of 5'-AMP in septicemia treatment
  • Use of 5'-AMP in septicemia treatment

Examples

Experimental program
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Embodiment Construction

[0018] The present invention uses 5'-AMP to induce hypothermia to treat sepsis, and observes the expression level of inflammatory factors and the infiltration of inflammatory cells, so as to provide possible theoretical guidance and basis for clinical research and development of new sepsis drugs.

[0019] Content and requirements:

[0020] Using rat sepsis animal model, H&E staining of pathological sections and other technical methods, low temperature was applied to the study of sepsis for the first time, ELISA was used to detect the expression levels of inflammatory factors and anti-inflammatory factors, and lung tissue was routinely analyzed for pathology.

[0021] Technical indicators:

[0022] 1. Control group: Rats were not treated with injection.

[0023] LPS group: rats were only injected with LPS intraperitoneally.

[0024] Prevention group: rats were intraperitoneally injected with 5'-AMP, and 1 hour later with intraperitoneal injection of LPS.

[0025] Treatment g...

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PUM

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Abstract

The present invention discloses a use of 5'-AMP in preparation of drugs for treatment or prevention of septicemia. Related test results show that: with application of the 5'-AMP in septicemia treatment, an inflammatory factor expression level in septicemia can be significantly reduced, an anti-inflammatory factor expression level can be improved, and lung tissue inflammation cell infiltration of the septicemia can be significantly reduced. In addition, the 5'-AMP is adopted as an injection drug for septicemia treatment, such that no obvious damage is generated to animals, no adverse side effect is generated, and the 5'-AMP is a safe and reliable drug for septicemia treatment.

Description

technical field [0001] The present invention relates to the new use of 5'-AMP for treating diseases, in particular to the use of 5'-AMP for treating sepsis. Background technique [0002] Sepsis refers to the acute systemic infection caused by pathogenic bacteria or opportunistic pathogenic bacteria invading the blood circulation, growing and multiplying in the blood, and producing toxins. Most of the onset is sudden, with chills or chills first, followed by high fever, variable heat type, flaccid fever or persistent fever; frail, severe malnutrition and young infants may have no fever, or even lower than normal body temperature. The patient is listless or irritable. In severe cases, the complexion may be pale or gray, confusion, cold extremities, shortness of breath, rapid heart rate, decreased blood pressure, and jaundice may also occur in infants and young children. [0003] Lipopolysaccharide (LPS) is a major component of the outer membrane of Gram-negative bacteria. Whe...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/7076A61P31/04
Inventor 王云龙苗志敏李长贵
Owner 王云龙
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