Astragalus mongholicus injection and preparation method thereof

A technology of Astragalus injection and injection, which is applied in the direction of medical formula, medical preparations containing active ingredients, drug delivery, etc., can solve the problem of not having the effect of the two major types of ingredients to exert curative effects together, and can not simultaneously improve the total saponins of Astragalus and Astragalus total flavonoids content and other issues, to achieve good adjuvant therapeutic effect, excellent effect, easy to operate

Active Publication Date: 2013-01-30
HEILONGJIANG ZBD PHARMA +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0016] In addition, there are also some research methods for separately purifying total astragalus saponins or total astragalus flavonoids through extraction methods. The resulting composition is a single category with high purity, and cannot simultaneously increase the

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  • Astragalus mongholicus injection and preparation method thereof
  • Astragalus mongholicus injection and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Example Embodiment

[0053] Example 1: Huangqi injection

[0054] 1. Take 1000g of Astragalus, add water and decoct 2 times, add 10 times and 8 times the weight of Astragalus respectively, and cook for 2 hours each time, combine the decoction, filter, and concentrate the filtrate to 745ml (each 1ml is equivalent to 1.34g of original medicinal materials), add 95% ethanol to make the ethanol content 73%, place in refrigeration for 20 hours, filter, recover the ethanol and concentrate until no alcohol taste, add water for injection to dilute to 385ml (each 1ml is equivalent to 2.60g of original medicinal materials ), placed in refrigeration for 20 hours, filtered to obtain a water extract, and recover the medicine residue;

[0055] 2. The recovered medicinal residue was refluxed and extracted twice with ethanol. Each time, 60% ethanol of 8 times the volume of Astragalus was added, and the extraction time was 1.5 hours each time. The extracts were combined, the ethanol was recovered and concentrated to no ...

Example Embodiment

[0057] Example 2: Huangqi Injection

[0058] 1. Take 1000g of astragalus, add water to decoct 2 times, add 8 times the weight of astragalus for the first time to decoct for 2 hours, add 6 times the amount of water to decoct for 1.5 hours, combine the decoction liquid, filter, The filtrate is concentrated to 675ml (each 1ml is equivalent to 1.48g of the original medicinal material), 95% ethanol is added to make the ethanol content 70%, refrigerated for 18 hours, filtered, the ethanol is recovered and concentrated to no alcohol, and diluted with water for injection to 392ml (Each 1ml is equivalent to 2.55g of the original medicinal material), placed in refrigeration for 18 hours, filtered to obtain a water extract, and recover the medicinal residue;

[0059] 2. The recovered medicinal residue was refluxed and extracted twice with ethanol. Each time, 8 times and 6 times the volume of Astragalus were added with 50% ethanol. The extraction time was 2 hours and 1.5 hours respectively. Th...

Example Embodiment

[0061] Example 3: Huangqi Injection

[0062] 1. Take 1000g of Astragalus, add water and decoct 3 times, add 10 times, 8 times, and 8 times of the weight of Astragalus respectively, and cook for 1.5 hours each time. Combine the decoction, filter, and concentrate the filtrate to 688ml ( Each 1ml is equivalent to 1.45g of the original medicinal material), add 95% ethanol to make the ethanol content 72%, refrigerate for 12 hours, filter, recover the ethanol and concentrate to no alcohol, add water for injection and dilute to 396ml (each 1ml is equivalent to 2.53g of original medicinal materials), put in refrigeration for 12 hours, filter, obtain water extract, and recover medicinal residue;

[0063] 2. The recovered medicinal residue was refluxed and extracted twice with ethanol. Each time, 10 times the volume of Astragalus and 8 times the volume of 95% ethanol were added. The extraction time was 1.5 hours. The extracts were combined, the ethanol was recovered and concentrated until no...

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Abstract

The invention relates to Astragalus mongholicus injection and a preparation method thereof. The injection contains two effective components: astragaloside and calycosin-7-glycoside. 1ml of Astragalus mongholicus injection contains 0.08-0.8mg of astragaloside and 0.02-0.4mg of calycosin-7-glycoside, wherein the astragaloside accounts for 1-10 percent of total solids, and the calycosin-7-glycoside accounts for 0.20-5 percent of the total solids. The injection provided by the invention is better in adjuvant therapeutic effect in the aspects of treating myocarditis, myocardial ischemia, cardiac failure, myocardial infarction and arrhythmia, and the therapeutic effect of the injection is superior to that of the prior art.

Description

technical field [0001] The invention relates to the field of astragalus preparations, in particular to an astragalus injection and a preparation method thereof. Background technique [0002] Astragalus is the root of the leguminous herb Astragalus mongolica and Astragalus membranaceus. Pharmacological studies have confirmed that Astragalus has the effects of strengthening the heart and expanding blood vessels, and Astragalus can improve cardiac systolic function while improving cardiac diastolic function, eliminating heart failure. In addition, it has a protective effect on the myocardium, which can protect the myocardium infected with ischemia and hypoxia, ischemia-reperfusion and virus, and can improve the electrical activity of cardiomyocytes, and has anti-arteriosclerosis and other effects. [0003] The chemical components of Astragalus mainly include saponins, flavonoids, polysaccharides and amino acids, among which saponins and flavonoids are the main medicinal compone...

Claims

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Application Information

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IPC IPC(8): A61K36/481A61K31/7048A61K9/08A61P9/04A61P9/06A61P9/10
Inventor 方同华
Owner HEILONGJIANG ZBD PHARMA
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