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Preparation method of carboxymethyl pachymaran

A technology for carboxymethyl tuckahoe and tuckahoe polysaccharide, which is applied in the field of preparation of carboxymethyl tuckahoe polysaccharide, can solve the problems of poor quality, low yield of carboxymethyl tuckahoe polysaccharide, etc., so as to improve the leaching rate, the yield and the product. Quality, the effect of improving product quality

Inactive Publication Date: 2013-01-30
HUBEI HONGYUAN PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0010] In order to solve the problems of low yield and poor quality in the production of carboxymethylparia cocos polysaccharide, the embodiment of the present invention provides a preparation method of carboxymethylparia cocos polysaccharide

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0048] The embodiment of the present invention provides a kind of preparation method of carboxymethyl pachyrhin, the specific preparation process is as follows:

[0049] 101. Peel the poria cocos block (that is, the sclerotia of Poria cocos), dry, repeatedly crush and pass through a No. 5 sieve (180±7.6 μm, 80 mesh) until the sieving rate is 90% to obtain a dry powder of Poria cocos, that is, pass through a No. 5 sieve , after crushing those that cannot be sieved, carry out No. 5 sieve again, until the quality of sieved Poria cocos dry powder is greater than 90% of the processed Poria cocos sclerotia mass, stop processing and obtain Poria cocos dry powder. Weigh 1 kg of Poria cocos dry powder and put it into a reaction kettle, prepare 10 L of 1.25 mol / L sodium hydroxide solution, put it into the reaction kettle, and stir and alkalinize it at 30°C for 1 hour to obtain an alkaline pachyrhin solution.

[0050] 102. According to the aforementioned method for detecting pachymane, d...

Embodiment 2

[0055] The embodiment of the present invention provides a kind of preparation method of carboxymethyl pachyrhin, the specific preparation process is as follows:

[0056] 201. Peel the poria cocos (i.e. Poria cocos sclerotia), dry, repeatedly crush and pass through a No. 5 sieve (180±7.6 μm, 80 mesh) until the sieving rate is 90% to obtain Poria cocos dry powder, weigh 1kg of Poria cocos dry powder and put it into In the reaction kettle, 10 L of 0.75 mol / L sodium hydroxide solution was prepared, put into the reaction kettle, and stirred and alkalized at 25° C. for 1 hour to obtain an alkaline pachymanan solution.

[0057] 202 . According to the aforementioned method for detecting pachyan, detect the quality of pachyan in the alkaline pachyan solution obtained in step 201 . In the embodiment of the present invention, it is detected that the quality of Poria cocos polysaccharide is 65.3% of the quality of Poria cocos dry powder, and if it is less than 70%, it is determined that t...

Embodiment 3

[0060] The embodiment of the present invention provides a kind of preparation method of carboxymethyl pachyrhin, the specific preparation process is as follows:

[0061] 301. Peel the poria cocos block (that is, the sclerotia of poria cocos), dry, repeatedly crush and pass through a No. 6 sieve (150±6.6 μm, 100 mesh) until the sieving rate is 92% to obtain a dry poria cocos powder, weigh 1 kg of poria cocos dry powder and put it into In the reaction kettle, 15 L of 0.75 mol / L sodium hydroxide solution was prepared, put into the reaction kettle, and stirred and alkalized at 25° C. for 3 hours to obtain an alkaline pachymanan solution.

[0062] 302 . According to the aforementioned method for detecting pachyan, detect the quality of pachyan in the alkaline pachyan solution obtained in step 301 . In the embodiment of the present invention, it is detected that the mass of Poria cocos polysaccharide is 72.3% of the mass of Poria cocos dry powder, if it is greater than 70%, step 303...

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Abstract

The invention discloses a preparation method of carboxymethyl pachymaran, belonging to the field of high-molecular polysaccharide. The method comprises the following steps: (1) dissolving dry powder of Poria cocos in a sodium hydroxide solution, conducting alkalization reaction to obtain an alkaline pachymaran solution, wherein the dry powder of Poria cocos is prepared by drying Poria cocos sclerotium, repeatedly crushing and sieving with No.5-7 sieves until the sieving rate is 90%; (2) detecting whether the weight of the pachymaran in the alkaline pachymaran solution is larger than 70% of the weight of the dry powder of Poria cocos, if yes, conducting the step (3); (3) adding a mixed solution of chloroacetic acid and sodium hydroxide to the alkaline pachymaran solution, conducting carboxymethylation to obtain a carboxymethyl pachymaran mixed liquor; and (4) separating and purifying the carboxymethyl pachymaran mixed liquor to obtain a finished product of carboxymethyl pachymaran. According to the invention, by strictly controlling the particle size of the dry powder of Poria cocos and the content of the pachymaran in the alkaline pachymaran solution in the preparation process of carboxymethyl pachymaran, the yield and product quality of carboxymethyl pachymaran are raised.

Description

technical field [0001] The invention belongs to the field of macromolecular polysaccharides, and in particular relates to a preparation method of carboxymethyl pachymane. Background technique [0002] Poria cocos, first recorded in "Shen Nong's Materia Medica", is called "the magic medicine of the four seasons". Its main components are β-tuckahoe polysaccharides and triterpenoids. Using traditional decoction methods, only less than 2 % of the active ingredient, the bioavailability is extremely low, and pachyran is insoluble in water and difficult to be absorbed by the human body, so it has no biological activity. Carboxymethyl pachyan is a deep-processed product of Poria cocos, which is a water-soluble polysaccharide semi-synthesized from carboxymethylated polysaccharide. Modern pharmacological studies have shown that carboxymethyl pachyrhin has the functions of anti-tumor, regulating the body's immune function, protecting the liver and reducing enzymes, indirect anti-virus...

Claims

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Application Information

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IPC IPC(8): C08B37/00
Inventor 冯菊红刘明良邱敏芳丁志华胡立志刘展良
Owner HUBEI HONGYUAN PHARMA
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