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Preparation method of Bitongxiao cataplasm

A technology of arthralgia and preparation steps is applied in the field of preparation of arthralgia and poultice, which can solve the problems of liver first-pass effect, inconvenient use of poultice and the like, and achieves the effects of good clinical effect and convenient use.

Inactive Publication Date: 2013-02-06
孔祥文
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, this cataplasm is not very convenient to use, and it is easy to cause the "first pass effect" of the liver

Method used

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Examples

Experimental program
Comparison scheme
Effect test

preparation example Construction

[0011] The preparation steps of the present invention are: dissolving some adhesives such as PVP-K30, gelatin, CMC-Na, etc. in water respectively, adding diatomaceous earth and stirring and mixing as phase A after merging; sodium polyacrylate (PANa), carbomer respectively Stir and mix with glycerin and use it as phase B; mix Bitongxiaoyao powder, glycolic aluminum and tartaric acid with glycerin and use it as phase C; slowly add phase B to phase A under stirring conditions, fully swell and mix, Then slowly add phase C into the mixed matrix of phase A and phase B, stir and mix thoroughly to form a viscous semi-solid fluid, immediately apply it on a pap plaster coating machine, and press to form it.

[0012] The proportioning of the present invention is: the content of PANa is 1~6%, the content of carbomer is 0.1~1.2%, the content of CMC-Na is 1~12%, the content of PVP-K 30 The content of tartaric acid is 2-8%, the content of gelatin is 1-10%, the content of tartaric acid is 0.8...

Embodiment 1

[0013] Embodiment 1: the content of PANa is 6%, the content of carbomer is 1.2%, the content of CMC-Na is 1%, PVP-K 30 The content of the gelatin is 8%, the content of the gelatin is 10%, the content of the tartaric acid is 1.4%, and the content of the aluminum glycylate is 0.7%.

Embodiment 2

[0014] Embodiment 2: the content of PANa is 1%, the content of carbomer is 0.1%, the content of CMC-Na is 1%, PVP-K 30 The content of the gelatin is 2%, the content of the gelatin is 5%, the content of the tartaric acid is 0.9%, and the content of the aluminum glycylate is 0.4%.

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PUM

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Abstract

The invention belongs to the field of medicine processing, and specifically relates to a preparation method of a Bitongxiao cataplasm. The Bitongxiao cataplasm provided by the invention is safe, and is convenient to apply. The Bitongxiao cataplasm provided by the invention is prepared from: 1-6% of PANa, 0.1-1.2% of carbomer, 1-12% of CMC-Na, 2-8% of PVP-K30, 1-10% of gelatin, 0.8-1.4% of tartaric acid, and 0.4-0.7% of dihydroxyaluminium aminoacetate.

Description

Technical field: [0001] The invention belongs to the field of medicine processing, and more specifically relates to a preparation method of Bitongxiao cataplasm. Background technique: [0002] Catapult patch, also known as cataplasm patch, is an external patch with water-soluble polymer as the matrix skeleton material, which was developed from ancient clay potions. Since the industrialized production in Japan in the 1970s, cataplasms have developed rapidly in Japan, and successfully entered the European and American markets in the 1980s. Introduced into our country at the same time. It belongs to a kind of transdermal drug delivery system or percutaneous absorption preparation. It is a type of preparation that is applied through the skin, and the drug is absorbed through the skin into the blood circulation of the whole body and reaches an effective blood concentration to achieve disease treatment or prevention. [0003] The effects of Babu patches are: it can avoid the fi...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/714A61K9/70A61K47/42A61P29/00A61P19/00
Inventor 孔祥文
Owner 孔祥文
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