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Preparation method for 2.0 generation of polyamidoamine PAMAM dendrimer

A technology of polyamidoamine dendrimers and macromolecules, which is applied in the field of polymer material preparation, can solve the problems of unreported research on polyamidoamine dendrimers, cumbersome synthesis steps, and high preparation costs, so as to reduce separation time and energy The effect of low consumption, simple preparation, and reduced number of separations

Inactive Publication Date: 2013-02-06
ANHUI UNIVERSITY OF TECHNOLOGY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] At present, the synthesis methods of polyamidoamine dendrimers mainly include divergent method, convergent method and divergent-convergent combination method, but no matter which synthesis method is adopted, multi-step reactions are required and multiple vacuum distillations are required for separation.
For example, when synthesizing 1.0-generation polyamidoamine dendrimers, two times of vacuum distillation are required; when synthesizing 2.0-generation polyamidoamine dendrimers, four times of vacuum distillation are required; to synthesize n-generation polyamidoamine dendrimers 2n times of vacuum distillation are required, which results in cumbersome synthesis steps and high preparation costs, which limit its application in industry
After literature search, it was found that there is no report on the preparation of polyamidoamine dendrimers by "one-pot method".

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0011] Example 1: First, add 0.01 mole of ethylenediamine and 0.1 mole of anhydrous methanol successively into a 250ml three-necked flask, slowly add 0.04 mole of methyl acrylate dropwise under stirring conditions, and react at a reaction temperature of 30°C 6h; then directly dropwise add ethylenediamine with a molar ratio of 0.04 moles for amidation reaction, and add anhydrous methanol with a molar ratio of 0.02 moles at the same time, and react for 24 hours at a reaction temperature of 20°C to obtain anhydrous methanol solution. Under stirring conditions, slowly add 0.08 moles of methyl acrylate dropwise, and react for 12 hours at a reaction temperature of 20°C; then add 0.08 moles of ethylenediamine dropwise for amidation reaction, and simultaneously add 0.04 moles of anhydrous methanol, At a reaction temperature of 20° C., react for 20 h, and finally distill off anhydrous methanol under reduced pressure to obtain a 2.0-generation polyamidoamine dendrimer.

Embodiment 2

[0012] Example 2: First, add 0.01 mole of ethylenediamine and 0.1 mole of anhydrous methanol successively into a 250ml three-necked flask, slowly add 0.04 mole of methyl acrylate dropwise under stirring conditions, and react at a reaction temperature of 25°C 10h; then directly dropwise add ethylenediamine with a molar ratio of 0.04 moles for amidation reaction, and add anhydrous methanol with a molar ratio of 0.02 moles at the same time, and react for 18 hours at a reaction temperature of 25°C to obtain anhydrous methanol solution. Under stirring conditions, slowly add 0.08 moles of methyl acrylate dropwise, and react for 12 hours at a reaction temperature of 20°C; then add 0.08 moles of ethylenediamine dropwise for amidation reaction, and simultaneously add 0.04 moles of anhydrous methanol, At a reaction temperature of 20° C., react for 24 hours, and finally distill off anhydrous methanol under reduced pressure to obtain a 2.0-generation polyamidoamine dendrimer.

Embodiment 3

[0013] Example 3: First, add 0.01 mole of ethylenediamine and 0.1 mole of anhydrous methanol into a 250ml three-necked flask, slowly add 0.04 mole of methyl acrylate dropwise under stirring conditions, and react at a reaction temperature of 20°C 12h; then directly dropwise add ethylenediamine with a molar ratio of 0.04 moles for amidation reaction, and add anhydrous methanol with a molar ratio of 0.02 moles at the same time, and react for 24 hours at a reaction temperature of 20°C to obtain anhydrous methanol solution. Under stirring conditions, slowly add 0.08 moles of methyl acrylate dropwise, and react for 12 hours at a reaction temperature of 20°C; then add 0.08 moles of ethylenediamine dropwise for amidation reaction, and simultaneously add 0.04 moles of anhydrous methanol, At a reaction temperature of 30° C., react for 12 hours, and finally distill off anhydrous methanol under reduced pressure to obtain a 2.0-generation polyamidoamine dendrimer.

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Abstract

The invention provides a preparation method for 2.0 generation of polyamidoamine (PAMAM) dendrimer, and belongs to the technical field of polymer materials. The method adopts a 'one-pot method' to synthesize PAMAM dendrimer, which greatly reduces synthetic procedures, lowers preparation cost, greatly reduces raw material and solvent consumption, and reduces separating frequency and dendrimer synthesize cost. The method can accelerate the realization of large-scale application of the PAMAM dendrimer in related industrial fields.

Description

technical field [0001] The invention belongs to the technical field of polymer material preparation, and in particular relates to a preparation method of 2.0 generation polyamidoamine dendrimers. Background technique [0002] Polyamidoamine dendrimers are a kind of polymer materials with hyperbranched structure, which are different from traditional branched polymers in structure, with controllable size and shape, internal cavities, and abundant functional groups on the surface. Dendrimers have been proposed for more than 20 years and are one of the current research hotspots. Dendrimers are usually composed of three different parts: the first part is the active center, which is the initial part of the dendrimer; the second part is the inner layer composed of multiple repeating branch units, located in the tree The middle part of the dendrimer; the third part is the outer layer with abundant surface functional groups, which is the end part of the dendrimer. These three parts ...

Claims

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Application Information

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IPC IPC(8): C08G83/00
Inventor 章昌华管猛王丽丽吴英古绪鹏杨建国乔红斌田雪梅
Owner ANHUI UNIVERSITY OF TECHNOLOGY
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