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Tetradotoxin mask and preparation method thereof

A technology of tetrodotoxin and sticking film, which is applied in the directions of pharmaceutical formulations, medical preparations containing active ingredients, and sheet delivery, etc., to achieve the effects of convenient use, hygienic use, and increased toxin production.

Active Publication Date: 2013-02-13
河北施坦纳生物科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] Botulinum toxin has been used as the main drug for beauty and wrinkle removal for many years. However, botulinum toxin is mainly injected, which is painful and needs to be implemented by professionals in specialized beauty institutions.

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment Construction

[0021] The present invention will be further described in detail below in conjunction with examples (the following drugs are calculated in parts by mass).

[0022] Apply the drugs in Examples 1 to 5 evenly on medical gauze or make a patch. The thickness of the drugs is subject to covering the gauze, which can be used to relieve itching and analgesia; evenly apply the drugs in Examples 7 to 9 It can be used for beauty and wrinkle removal on the mask paper or made into a sticker.

[0023] The preparation steps are:

[0024] A. Tetrodotoxin extraction:

[0025] Collect the tetrodotoxin dialysis culture broth, and then centrifuge it at 0℃. Take the supernatant and mix it with picric acid at a ratio of 1.1:1. The resulting mixture is mixed with boiling water at a ratio of 1:6 and filtered while hot ;

[0026] Cool the filtrate to obtain a crystalline precipitate, separate the crystalline precipitate, and recrystallize the precipitate in boiling water three times to obtain a yellow needle-...

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PUM

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Abstract

The invention discloses a tetradotoxin mask and a preparation method of the mask. The tetradotoxin mask comprises an active pharmaceutical ingredient tetradotoxin, stabilizer lactose, a complex solubilizer citric acid, zinc oxide, rosin, vaseline and mint essential oil and the like. Based on different amounts of tetradotoxin contained in the mask, the mask has the effects of relieving itching, easing pain and lifting face. The tetradotoxin mask changes the traditional administration manner of tetradotoxin, and is more convenient to use. The tetradotoxin mask is low in price, simple and easy to manufacture, fast in effect, long in lasting time, healthy and clean. In addition, the mask further conquers the social safety hazard caused by the original tetradotoxin injection is missed, and facilitates promoting normalization of the face lifting item. The consumer can quickly, conveniently and comfortably care the skins without beautifying medical institutions.

Description

Technical field [0001] The invention relates to a medicine for external use of tetrodotoxin, in particular to a tetrodotoxin film. Background technique [0002] Tetrodotoxin (TTX) is a small molecular weight, non-protein compound, its molecular formula: C 11 H 17 N 3 O 8 , The molecular weight is 319.27. Tetrodotoxin has a local stimulating effect on the intestinal tract. After it enters the body and is absorbed, it acts on the nerve endings and nerve center through the blood circulation. It can block the voltage-dependent sodium ions on the nerve excitatory membrane with high selectivity and high affinity Channel, thereby blocking the biological potential, inhibiting the excitatory conduction between nerves and muscles, and ultimately leading to related physiological dysfunctions, mainly manifested as muscle and nerve paralysis, which can play the role of analgesia, anesthesia, and detoxification. Clinically, it is mainly used in internal medicine, surgery, dermatology and othe...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/70A61K31/529A61P17/04A61P17/16A61P29/02
Inventor 林涛武斌
Owner 河北施坦纳生物科技有限公司
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