Unlock instant, AI-driven research and patent intelligence for your innovation.

Method for extracting total flavone from guava leaves

A technology for guava leaves and total flavonoids, which is applied in the field of extracting total flavonoids, can solve the problems of high cost and low content of total flavonoids, and achieves the effects of low cost, simple method and high efficiency

Inactive Publication Date: 2013-02-13
哈药集团中药二厂
View PDF0 Cites 8 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] The present invention aims to solve the technical problems of high cost and low content of total flavonoids in the obtained extract in the traditional extraction method, thereby providing a method for extracting total flavonoids from guava leaves

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Examples

Experimental program
Comparison scheme
Effect test

specific Embodiment approach 1

[0016] Specific embodiment one: a kind of method extracting total flavonoids from guava leaf in the present embodiment is carried out according to the following steps:

[0017] 1. Take 50-60kg of guava leaves, decoct them with water for at least 2 times, filter, combine the decoction liquid, and concentrate at a temperature of 60-80°C until the relative density is 1.12-1.14g / cm 3 The clear paste; wherein the first decocting water consumption is 14 to 20 times the guava leaf quality, the second decoction water consumption is 10 to 14 times the guava leaf quality, each decoction water consumption Decrease by 20% to 30% in turn, and each decoction takes 1 to 3 hours;

[0018] 2. Add water to the clear paste obtained in step 1 until the volume is 150-200L, then adjust the pH value to 6.0-7.0 with 2-4mol / L sodium hydroxide solution, soak for 12-24 hours, collect the supernatant, and use 4 ~5mol / L hydrochloric acid solution to adjust the pH value of the supernatant to 2.0~3.0, let ...

Embodiment approach

[0022] This embodiment includes the following effects:

[0023] 1. This embodiment adopts the polyamide purification method. The polyamide resin is a kind of polymer material formed by the polymerization of amides. It has strong adsorption properties for flavonoids, mainly through hydrogen bonds and van der Waals forces. In this embodiment, only low-cost eluents such as ethanol and acetone are used, so the cost is low, and the method is simple, high in efficiency, good in stability and easy to regenerate, and the obtained product is safe and free of heavy metal and organic solvent toxicity problems such as residues;

[0024] 2. According to the pharmaceutical method, the total flavonoids of the effective parts of guava leaves in this embodiment can be made into various pharmaceutical preparations suitable for clinical use. Various dosage forms include oral formulations as well as parenteral formulations. The oral preparations can be made into granules, tablets, capsules, pil...

specific Embodiment approach 2

[0026] Embodiment 2: The difference between this embodiment and Embodiment 1 is that each decoction in step 1 takes 1.5 hours. Others are the same as in the first embodiment.

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

PUM

PropertyMeasurementUnit
Relative densityaaaaaaaaaa
Login to View More

Abstract

The invention discloses a method for extracting the total flavone from guava leaves and relates to a method for extracting the total flavone from raw materials, solving the technical problems that the conventional extraction method is high in cost and the total flavone content of the obtained extract is low. The method comprises the following steps of: 1, decocting the guava leaves with water and then concentrating so as to obtain clear paste; 2, mixing the clear paste with the water, standing, collecting supernatant, so that extracting solution is obtained; 3, pretreating with a polyamide resin column; 4, purifying the extracting solution through the polyamide resin, and collecting ethanol eluant; and 5, distilling the ethanol eluant at reduced pressure, and carrying out reduced pressure concentration and reduced pressure drying so as to obtain the guava leaf extract. The method is applied to the field of preparation of the guava leaf extract.

Description

technical field [0001] The invention relates to a method for extracting total flavonoids from raw materials. Background technique [0002] The guava leaves are the dry leaves and tender stems with leaves of the Myrtaceae plant Psidium Guajaua L. Recorded in "Guangxi Standards of Chinese Medicinal Materials", it is called "Ma Guo" in Brown language. The air is delicate and fragrant, the taste is astringent, slightly sweet and bitter, has astringent and antidiarrheal, anti-inflammatory and hemostasis. For chronic dysentery, diarrhea, diabetes, wound bleeding, skin eczema, itching, prickly heat, toothache, modern pharmacological research shows that guava leaves have hypoglycemic, antibacterial, antiviral, and antioxidant effects. [0003] There are many studies on guava leaves in the literature. Pharmacological studies have shown that the active ingredients extracted from guava leaves are effective for patients with type 2 diabetes, and suggest that their pharmacological effe...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

Application Information

Patent Timeline
no application Login to View More
IPC IPC(8): A61K36/61A61P3/10A61P31/04A61P31/12A61K127/00A61K135/00
Inventor 吴志军李云涛任瑞涛王丽娜单钰毓陈玉李殿明
Owner 哈药集团中药二厂