Magnetic mesoporous bioactive glass drug delivery system and preparation method thereof

A technology of biological glass and delivery system, applied in the fields of medical science, prosthesis, inorganic inactive ingredients, etc., can solve the problems of cytotoxicity and increase biocompatibility, and achieve increased drug loading, broad application prospects, and excellent drug loading. and sustained release properties

Inactive Publication Date: 2015-01-21
SHANGHAI NORMAL UNIVERSITY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, their invention and preparation did not completely solve the related disease problems caused by bone repair transplantation, which made us have to build a new functional material system in order to achieve the purpose of reducing cytotoxicity and increasing biocompatibility

Method used

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  • Magnetic mesoporous bioactive glass drug delivery system and preparation method thereof
  • Magnetic mesoporous bioactive glass drug delivery system and preparation method thereof
  • Magnetic mesoporous bioactive glass drug delivery system and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1-6

[0025] First place 4gP123 in 50mL of ethanol and stir vigorously to obtain a uniform surfactant ethanol dispersion solution; then prepare the inorganic precursor, in order to obtain the SiO as shown in Table 1 2 :CaO:P 2 o 5 :Fe 3 o 4 The mass ratio of the magnetic mesoporous bioglass drug delivery system, respectively adding inorganic substances in order, wherein the first group of embodiments specifically: 1.25g calcium nitrate tetrahydrate, 8.6mL (8g) tetraethyl orthosilicate (TEOS) , 0.35mL (0.37g) triethyl phosphate (TEP), 0.142g nano Fe 3 o 4 particles, then add 1-3 mL of dilute HNO 3 (1mol / L) solution is catalytically hydrolyzed at a reaction temperature of 40°C; after the inorganic precursor is hydrolyzed and dispersed evenly, the surfactant ethanol dispersion solution is added, and the reaction is fully mixed for soft template sealing and self-assembly into a sol-gel. Dry in an oven at ℃ for 1-3 days, and calcinate the gel obtained after aging at 550-700℃ for 5-...

Embodiment 7

[0029] According to the steps in Example 1, no magnetic nanoparticles were added, other processes and conditions were the same as in Example 1, and finally a non-magnetic mesoporous bioglass drug delivery system was obtained, which was the blank control group.

Embodiment 8

[0031]The magnetic mesoporous bioglass drug delivery system prepared in Example 1 was selected for drug loading and sustained release experiments.

[0032] (1) Drug loading: Weigh 30mg powder gentamicin sulfate in the glove box under the protection of inert gas, dissolve it in 50mL deionized water to make a 600μg / mL gentamicin sulfate solution; take 0.5g sample and put it in the solution , under constant temperature and vigorous stirring at 37°C for 24h. Centrifuge at 8000r / min, dry the lower precipitate in a vacuum oven at 37°C, and keep the upper clear for drug loading test.

[0033] (2) Drug release: Weigh 0.2 g of the drug-loaded sample, press it into a sheet with a diameter of 2-3 cm with a tablet machine, soak the sample in 100 mL of deionized water, and use UV- A visible spectrophotometer detects the drug concentration in solution. Its drug release profile is as follows Figure 4 shown.

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Abstract

The invention discloses a magnetic mesoporous bioactive glass drug delivery system and a preparation method thereof, and the preparation process is carried out with a surface active agent as a soft template by a sol-gel method. The magnetic mesoporous bioactive glass drug delivery system is provided with a specific surface area of the material of 300-1000 cm<2> / g and a mesoporous diameter of 2-50 nm, and the structure of the mesoporous is adjustable. Through loading gentamicin sulphate and other antibiotics on the surface of the material and carrying out drug sustained release, the results shows that the magnetic mesoporous bioactive glass drug delivery system has good drug loading efficiency and slow release performance, and is not influenced by the types of the loaded antibiotics and the like.

Description

technical field [0001] The invention relates to the technical field of inorganic non-metallic materials and medical materials, in particular to the preparation of a magnetic mesoporous bioglass drug delivery system. Background technique [0002] Bioglass, as a kind of bone repair and scaffold material, has been successfully applied to a variety of tissue repair materials after clinical operations. The most important reason is that its chemical composition is very similar to human bone and has excellent biocompatibility And self-degradation performance, it can form a tight combination with bone after implanted in the human body, and quickly and effectively promote bone repair, so it has good osteogenesis performance. Nowadays, for bone defects caused by bone tumors and other diseases, biomaterials are not only required to effectively repair bone, but also have the function of treating related diseases. The development and expansion of new high-efficiency bioglass has become ...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K47/08A61K47/02A61L27/12A61L27/02A61L27/56
Inventor 郭亚平余锡宾刘怡卓阳俊
Owner SHANGHAI NORMAL UNIVERSITY
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