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Synovitis treating medicine and preparation method thereof

A technology for synovitis and medicine, applied in the field of medicine, can solve the problems of extensive extraction method, unsatisfactory anti-inflammatory and analgesic effects, and imperfect formula composition, and achieves the effects of reasonable proportioning and anti-inflammatory and analgesic effects.

Active Publication Date: 2013-02-27
SHINEWAY PHARMA ZHANGJIAKOU
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, there are still some unsatisfactory aspects in the existing traditional Chinese medicine preparations for the treatment of synovitis, such as: the formula composition is not perfect, and the extraction method is relatively extensive, resulting in unsatisfactory anti-inflammatory and analgesic effects

Method used

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  • Synovitis treating medicine and preparation method thereof
  • Synovitis treating medicine and preparation method thereof
  • Synovitis treating medicine and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0020] The preparation of embodiment 1 granule

[0021] a. Weigh 15.5g of Prunella vulgaris, 10.3g of Smilax smilax, 9.5g of Hanfangji, 13.0g of coix seed, 7.8g of salvia miltiorrhiza, 5.3g of angelica, 3.9g of euphemum, 4.5g of Achyranthes bidentata, 6.7g of loofah, 6.7g Brassica officinalis, 8.4g Astragalus membranaceus, 6.5g Ligustrum lucidum, 6.5g Gonggong leaves, decoct twice with water, 2 hours each time, filter after decoction, combine the filtrates of the two decoctions and concentrate to relative density is 1.05 (66°C), and clear paste is obtained;

[0022] b. Add an equal volume of ethanol to the clear paste, stir evenly, let it stand for 24 hours, filter, recover ethanol from the filtrate, concentrate to a relative density of 1.34 (66°C), and obtain a thick paste;

[0023] c. After the thick paste is dried and pulverized, 50 mL of ethanol is added as a binding agent, and 20 g of starch is used as a filler, and wet granules are made by extrusion, and the granules fo...

Embodiment 2

[0024] The preparation of embodiment 2 capsules

[0025] a. Weigh 16.7g of Prunella vulgaris, 10.6g of Smilax smilax, 10.3g of Hanfangji, 13.8g of Coix seed, 8.8g of Salvia miltiorrhiza, 6.7g of angelica, 4.5g of Eupatorium, 5.0g of Achyranthes bidentata, 7.6g of loofah, and Stem 7.6g, Astragalus 9.0g, Ligustrum lucidum 7.2g, Gonggong leaves 7.2g, decoct 4 times with water, 5 hours each time, filter after decoction, combine the filtrates and concentrate to a relative density of 1.14 (66°C ), to get clear ointment;

[0026] b. Add 2 times the volume of ethanol to the clear ointment, stir evenly, let it stand for 48 hours, filter, recover ethanol from the filtrate, concentrate to a relative density of 1.36 (66°C), and obtain a thick ointment;

[0027] c. Add 5 g of sucrose and 10 g of dextrin to the thick paste, mix well, make wet granules, dry, mix well again, pack into capsule shells, and make capsules for treating synovitis.

Embodiment 3

[0028] The preparation of embodiment 3 tablet

[0029] a. Weigh 16.0g of Prunella vulgaris, 10.8g of Smilax smilax, 10.2g of Hanfangji, 13.3g of Coix seed, 8.7g of Salvia miltiorrhiza, 6.5g of angelica, 4.3g of Eupatorium, 4.7g of Achyranthes bidentata, 7.1g of loofah, and Stem 7.3g, Astragalus 8.6g, Ligustrum lucidum 6.9g, Gonggong leaves 6.9g, decoct 3 times with water, 3 hours each time, filter after decoction, combine the filtrates and concentrate to a relative density of 1.12 (66°C ), to get clear ointment;

[0030]b. Add 1.5 times the volume of ethanol to the clear ointment, stir evenly, let it stand for 36 hours, filter, recover ethanol from the filtrate, concentrate to a relative density of 1.35 (66°C), and obtain a thick ointment;

[0031] c. After the thick paste is dried and pulverized, 10 g of lactose and 50 g of microcrystalline cellulose are added, mixed evenly and pressed into a tablet for treating synovitis.

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Abstract

The invention discloses a synovitis treating medicine and a preparation method thereof. The medicine is prepared from the following traditional Chinese medicines in parts by weight: 12.0-14.0 parts of spica prunellae, 8.7-9.5 parts of rhizoma smilacis glabrae, 8.7-9.5 parts of tetrandra root, 13.0-13.8 parts of semen coicis, 6.3-7.1 parts of radix salviae miltiorrhizae, 4.1-4.9 parts of Chinese angelica and 6.5-7.3 parts of herba siegesbeckiae. The invention also provides the preparation method of the medicine, which comprises the steps of decocting, filtering and concentrating to obtain a thick paste, and adding conventional accessories into the thick paste to obtain the medicine in a clinically acceptable form. The synovitis treating medicine disclosed by the invention has good anti-inflammation and analgesic effects.

Description

technical field [0001] The invention belongs to the field of medicine, and in particular relates to a medicine for treating synovitis and a preparation method thereof. Background technique [0002] Synovitis is a multiple disease, its clinical manifestation is usually joint pain, and its etiology includes trauma, rheumatism, joint degenerative disease, tuberculosis infection and so on. According to the theory of traditional Chinese medicine, the pathogenesis of synovitis is "damp-heat block collaterals, water-dampness stagnation", protracted illness can consume qi and blood and be depleted, while synovitis caused by trauma is often accompanied by blood stasis. [0003] At present, synovitis can be treated clinically by arthrocentesis, pressure bandage, local immobilization, physical therapy, and intra-articular steroid injection. The above-mentioned treatment methods have a long course of treatment, and the therapeutic effect is not ideal enough. In contrast, the use of tr...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/90A61P19/04
Inventor 刘军锋郭沛鑫张志伟刑云涛姜海胡雪娇
Owner SHINEWAY PHARMA ZHANGJIAKOU
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