Preparation method of chiral intermediate cyclohexane dimethanol

A technology of cyclohexanedimethanol and chiral intermediate, applied in the field of medicine, can solve the problems of high cost, large amount of red aluminum, unfavorable industrial production, etc., and achieves the effects of low price and stable properties
CN102952001AInactive Publication Date: 2013-03-06TIANJIN INSTITUTE OF PHARMA RESEARCH
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Patent Information

Authority / Receiving Office
CN · China
Patent Type
Applications(China)
Current Assignee / Owner
TIANJIN INSTITUTE OF PHARMA RESEARCH
Publication Date
2013-03-06
Estimated Expiration
Not applicable · inactive patent

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Abstract

The invention belongs to the technical field of medicine, and specifically relates to a preparation method of a chiral intermediate 1R,2R-cyclohexane dimethanol. The chiral intermediate 1R,2R-cyclohexane dimethanol is an important intermediate of an antischizophrinic medicine lurasidone. Lurasidone has substantially treatment effects against both positive and negative symptoms of mental patients. A reduction agent adopted by the invention has low cost and stable property. The preparation method is suitable for industrialized productions.
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Description

technical field

[0001] The invention belongs to the technical field of medicine, and in particular relates to a preparation method of a chiral medicine intermediate 1R, 2R-cyclohexanedimethanol. Background technique

[0002] The chiral compound 1R, 2R-cyclohexanedimethanol (I) is an important intermediate of the anti-schizophrenia drug Lurasidone. Lurasidone is a dual-action antipsychotic drug, which has high affinity for both 5-HT2 receptors and dopamine D2 receptors, and has a significant effect on both positive and negative symptoms of psychosis.

[0003]

[0004] Japanese patent JP2004-224764 reported the preparation method of 1R, 2R-cyclohexanedimethanol: using 1R, 2R-cyclohexanedicarboxylic acid as raw material, using red aluminum solution as reducing agent to obtain the target compound, the amount of red aluminum used in this method Large, the reduction of 1g of 1R, 2R-cyclohexanedicarboxylic acid requires about 5g of red aluminum solution, which is expensive and ...

Claims

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