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Total flavone extract of Hyssopus officinalis, preparation method thereof and application thereof

A technology for the extraction and preparation of total flavonoids of the herb and its total flavonoids, which can solve the undiscovered problems of the preparation method, pharmacological activity and medicinal use of the total flavonoids of the herb, making the extraction method safe and simple, and highlighting technological progress , good repeatability

Inactive Publication Date: 2013-03-13
XINJIANG MEDICAL UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

So far, no literature has been found on the preparation method, pharmacological activity and medicinal use of the total flavonoids of the herb

Method used

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  • Total flavone extract of Hyssopus officinalis, preparation method thereof and application thereof
  • Total flavone extract of Hyssopus officinalis, preparation method thereof and application thereof
  • Total flavone extract of Hyssopus officinalis, preparation method thereof and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0017] The medicinal herb selected is dried whole herb, which is used after being crushed through a 20-mesh sieve; the sieved divine herb is placed in a 10L round-bottomed flask, and the volume percentage concentration is 60% ethanol / water for extraction, ethanol / water is 6 times the weight of the herbal medicinal herb, heated in a water bath to 70°C, extracted once under reflux for 2 hours, filtered the extract, concentrated the filtrate under reduced pressure to 1.0 g crude drug / mL, and obtained the extract of the herb; Extract, add 1 times the amount of water to dilute, let it stand for 12 hours, remove insoluble substances by suction filtration, and concentrate the filtrate to 1.0g crude drug / mL; the medium sample of Shenxiangcao extract is adsorbed by HPD-300 macroporous adsorption resin, Shenxiangcao The weight ratio to the macroporous adsorption resin is 1:1, the concentration of flavonoids in the sample solution is 1.28mg / mL, the flow rate of the sample is 3BV / h, and th...

Embodiment 2

[0019] The medicinal herb for selection is dried whole herb, which is used after being crushed through a 20-mesh sieve; the sieved herb is placed in a 10L round-bottomed flask, and the volume percentage concentration is 70% ethanol / water for extraction, ethanol / water is 8 times the weight of the herbal medicinal herb, heated to 80°C in a water bath, extracted 3 times under reflux, the extraction time was 1 hour, the extract was filtered, and the filtrate was concentrated under reduced pressure to 0.25g crude drug / mL to obtain the extract of the herb; Vanilla extract, add 3 times the amount of water to dilute, let it stand for 18 hours, remove insoluble substances by suction filtration, and concentrate the filtrate to 0.25g crude drug / mL; use AB-8 macroporous adsorption resin to absorb the Chinese herb extract, The weight ratio of vanilla to macroporous adsorption resin is 1:4, the concentration of flavonoids in the sample solution is 2.56mg / mL, the flow rate of the sample is 4B...

Embodiment 3

[0021] The medicinal herb for selection is dried whole herb, which is used after being crushed through a 20-mesh sieve; the sieved herb is placed in a 10L round-bottomed flask, and the volume percentage concentration is 75% ethanol / water for extraction, ethanol / water is 10 times the weight of the herbal medicinal herb, heated in a water bath to 60°C, extracted twice under reflux for 3 hours, filtered the extract, concentrated the filtrate under reduced pressure to 0.5g crude drug / mL, and obtained the extract of the herb; Vanilla extract, add 2 times the amount of water to dilute, let it stand for 24 hours, remove insoluble substances by suction filtration, and concentrate the filtrate to 0.5g crude drug / mL; use HPD-600 macroporous adsorption resin to absorb the Chinese herb extract, The weight ratio of vanilla to macroporous adsorption resin is 1:6, the concentration of flavonoids in the sample solution is 3.84mg / mL, the flow rate of the sample is 5BV / h, and the diameter-to-hei...

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Abstract

The invention provides a total flavone extract of Hyssopus officinalis, a preparation method thereof and an application thereof. The method comprises extracting whole plant of the Uygur medicine Hyssopus officinalis by using aqueous ethanol, and enriching by using macroporous resin to obtain the total flavone of the Hyssopus officinalis, wherein a content of the total flavone is not less than 65 % of the total flavone extract of the Hyssopus officinalis. The total flavone of Hyssopus officinalis provided by the invention has effects of anti inflammatory, cough relieving, eliminating phlegm, relieving asthma, etc.; and preparations prepared by using the total flavone of the Hyssopus officinalis as raw materials and adding different medicament excipients can be used as medicaments for treating cold, pneumonia, bronchitis and asthma. The preparation method is safe and simple, good in repeatability, no environmental pollution and suitable for large-scale production.

Description

technical field [0001] The invention relates to the extraction of traditional Chinese medicinal materials, and the method is especially suitable for the extraction and preparation of the total flavonoids of the herb. Background technique [0002] Hyssopus cuspidatus Boriss. (Hyssopus cuspidatus Boriss.) or the same plant (Hyssopus officinalis L.) is the dried whole herb of the Labiatae plant. In "Drug Standards of the Ministry of Health of the People's Republic of China: Uyghur Medicine Sub-volume" (Urumqi: Xinjiang Science and Technology Health Publishing House, 1999), "Chinese Materia Medica Uyghur Medicine Volume" (Shanghai: Shanghai Science and Technology Press, 2005), "Uyghur Medicine Chronicles (Volume 1) (Urumqi: Xinjiang Science and Technology Health Publishing House, 1999). It is recorded in the "Drug Standards of the Ministry of Health of the People's Republic of China: Uyghur Medicine Sub-volume": Shenxiang grass matures and removes abnormal mucus, promotes the b...

Claims

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Application Information

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IPC IPC(8): A61K36/53A61P29/00A61P11/14A61P11/10A61P11/06A61P11/00
Inventor 阿不都热依木·玉苏甫哈木拉提·吾甫尔麦合苏木·艾克木安尼瓦尔·托乎提
Owner XINJIANG MEDICAL UNIV
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