Drug for treating herpes simplex virus keratities

A technology for viral keratitis and herpes simplex, applied in the direction of antiviral agents, drug combinations, sensory diseases, etc., can solve problems such as ineffectiveness, damage to corneal tissue, damage to the immune mechanism of the body, etc., to achieve the effect of reasonable compatibility and good curative effect

Inactive Publication Date: 2013-03-13
王正艳
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] At present, the clinical treatment methods for herpes simplex virus keratitis mainly include: focus debridement, suitable for superficial cases, the principle is to remove infected cells and viruses through physical or chemical methods, including mechanical debridement, chemical debridement, etc. Debridement, freezing debridement, photoinactivation therapy, debridement of the lesion can only remove infected cells but not prevent virus reproduction, may damage the corneal epithelial basement membrane and stromal layer, and promote the development of lesions to the deep, cryotherapy has no effect on the vitality of HSV Antiviral drugs, such as iodinidine, cytarabine, trifluorothymidine, etc., are mostly used in the late treatment of herpes simplex virus keratitis; corticosteroids, inhibit the release of histamine and toxic lytic enzymes, and reduce inflammation Reaction and tissue damage, reduce scar formation, promote angiogenesis, but there is also the risk of damaging the immune mechanism of the body and corneal tissue; surgical treatment, suitable for deep ulcers, stromal necrotizing keratitis combined with perforation, relying on drugs and conservative treatment alone Conditions that have been ineffective, including conjunctival flap covering, anterior chamber puncture, lamellar or penetrating keratoplasty, surgical therapy has clinical surgical risks

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0042] The raw material composition and the weight of active ingredient of medicine of the present invention are:

[0043] 46g of chrysanthemum, 42g of chrysanthemum, 39g of red peony, 36g of dandelion

[0044] Diding 32g, Cuscuta 29g, Chanyi 25g, Plantago 22g

[0045] Mint 19g Cassia 16g Akebia 12g Gujingcao 10g

[0046] The processing steps of the pharmaceutical preparation method of the present invention are:

[0047] (1) Put Chanyi, Chishao and Diding into the pot, stir-fry over low heat until slightly burnt yellow, take it out and let it cool, grind it into powder, pass through 120 mesh fine powder, and set aside.

[0048] (2) Put chrysanthemum, dandelion, psyllium, mint, akebia, and Gu Jingcao into the container, add six times the amount of water, boil and continue soaking for 8 to 10 hours, then take the soaking liquid; Add four times the amount of water to the medicinal dregs, boil and continue soaking for 5 to 7 hours, then take the soaking liquid; combine the soak...

Embodiment 2

[0053] The raw material composition and the weight of active ingredient of medicine of the present invention are:

[0054] 41g of chrysanthemum, 38g of hot pepper, 35g of red peony, 32g of dandelion

[0055] Diding 29g, Cuscuta 25g, Chanyi 22g, Plantago 19g

[0056] Mint 15g Cassia 13g Akebia 10g Gujingcao 7g

[0057] The process steps, usage and dosage of the medicine preparation method in this embodiment are the same as those in Example 1.

Embodiment 3

[0059] The raw material composition and the parts by weight of the pharmaceutical active ingredient of the present invention are:

[0060] 38g chrysanthemum, 35g hot pepper, 32g red peony, 28g dandelion

[0061] Diding 25g, Cuscuta 22g, Chanyi 19g, Plantago 15g

[0062] Mint 13g Cassia 10g Akebia 8g Gujingcao 5g

[0063] The process steps, usage and dosage of the medicine preparation method in this embodiment are the same as those in Example 1.

[0064] clinical information:

[0065] Clinical follow-up data shows that the cure rate of the medicine of the present invention is 63.7% for superficial stromal keratitis, and the improvement rate reaches 95.2%, and the cure rate for deep stromal keratitis is 54.3%, and the improvement rate reaches 89.6%. The cure rate of herpes simplex virus keratitis was 51.2%, and the improvement rate was 83.8%, which completely reached the clinical treatment standard for herpes simplex virus keratitis and was suitable for popularization and app...

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PUM

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Abstract

The invention discloses a drug for treating herpes simplex virus keratities, belonging to the field of traditional Chinese medicine. The drug comprises the active ingredients in parts by weight: 34-50 parts of chrysanthemum, 30-46 parts of garden balsam, 28-44 parts of radix paeoniae rubra, 25-40 parts of dandelion, 22-36 parts of viola yedoensis, 18-32 parts of semen cuscutae, 15-28 parts of periostracum cicada, 12-25 parts of semen plantaginis, 10-22 parts of corn mint, 8-18 parts of semen cassiae, 5-15 parts of caulis akebiae and 3-12 parts of pipewort. The drug is reasonable in compatibility, and excellent to prepare, is based on clearing heat and detoxifying and dispersing wind and heat, achieves the purposes of inducing diuresis with bland drug and tonifying the liver and kidney, and pursues the effects of removing nebula aiming at the pathopoiesia factors of sthenia syndrome and fever syndrome, wind-heat exterior sthenia, spleen deficiency and damp-heat, liver and gall fire toxin and the like causing herpes simplex virus keratities, and has better curative effects on superficial stromal keratitis, deep stromal keratitis and degenerated herpes keratities.

Description

Technical field [0001] The invention relates to the field of traditional Chinese medicines, in particular to a medicine for treating herpes simplex virus keratitis. Background technique [0002] Herpes simplex virus keratitis is the most serious common corneal disease at present, and it has a clear rising and aggravating trend in recent years. Due to recurrent attacks and increasing number of severe cases, it seriously threatens visual function, so strengthening the research on this disease has become an urgent problem to be solved in ophthalmology. The clinical manifestations of this disease are complicated. In addition to the typical shape of branches, maps and disc-shaped corneal lesions, there are also some atypical clinical changes, which bring great difficulties to diagnosis and treatment. Each type not only has unique clinical characteristics, but also has different pathogenesis and treatment principles. The various types of staining can be transformed into each othe...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/88A61P27/02A61P31/22A61K35/64
Inventor 王正艳
Owner 王正艳
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