Small complex prescription of traditional Chinese medicine for preventing and treating glucocorticoids-induced osteoporosis, and preparation method thereof

A technology for osteoporosis and glucocorticoid, which is applied in the field of medicine and achieves the effects of moderate dosage, convenient administration and positive curative effect

Inactive Publication Date: 2013-03-20
CAPITAL UNIVERSITY OF MEDICAL SCIENCES
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Of course, we still need to pay attention to the law-abiding and prescription treatment. Because this disease is a major chronic disease, the eff

Method used

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Examples

Experimental program
Comparison scheme
Effect test

example 1

[0023] Epimedium 15kg, Ligustrum lucidum 15kg

[0024] Mix 15kg of Epimedium and 15kg of Ligustrum lucidum, soak in 240kg of water for 30min, decoct twice, 1hr each time. Combine the two decoctions and concentrate to the extract with a relative density of 1.15-1.20. Add 95% ethanol to make the alcohol content reach 60%. Let it stand overnight, take the supernatant to recover ethanol under reduced pressure, concentrate to an extract with a relative density of 1.3, dry under reduced pressure, and grind into fine powder. Mix 2.4kg of extract powder and 2.4kg of dextrin at a ratio of 1:1 to make a soft material, sieve to make granules, dry at 70°C under normal pressure for 4 hours, and use 0.5g per package.

example 2

[0026] Epimedium 12kg, Ligustrum 8kg

[0027] Mix 12kg of Epimedium and 8kg of Ligustrum lucidum, soak in 160kg of water for 30min, decoct twice, 1hr each time. Combine the two decoctions and concentrate to the extract with a relative density of 1.15-1.20. Add 95% ethanol to make the alcohol content reach 60%. Let it stand overnight, take the supernatant to recover ethanol under reduced pressure, concentrate to an extract with a relative density of 1.3, dry under reduced pressure, and grind into fine powder. Mix 1.5kg of extract powder and 1.5kg of dextrin at a ratio of 1:1 to make a soft material, sieve to make granules, dry at 70°C under normal pressure for 4 hours, granulate, and pack into capsules, each containing 0.5g.

example 3

[0029] Epimedium 12kg, Ligustrum 8kg

[0030] Mix 12kg of Epimedium and 8kg of Ligustrum lucidum, soak in 160kg of water for 30min, decoct twice, 1hr each time. Combine the two decoctions and concentrate to a clear paste with a relative density of 1.15-1.20. Add 95% ethanol to make the alcohol content reach 60%. Let it stand overnight, take the supernatant to recover ethanol under reduced pressure, concentrate to an extract with a relative density of 1.3, dry under reduced pressure, and grind into fine powder. Mix 1.5kg of extract powder and 1.5kg of dextrin in a ratio of 1:1 to make a soft material, sieve to make granules, dry at 70°C under normal pressure for 4 hours, add 0.5% magnesium stearate to mix, and sieve the granules for 14 days. After compression, each tablet weighs 0.4g.

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PUM

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Abstract

The invention provides a small complex prescription of a traditional Chinese medicine for preventing and treating glucocorticoids-induced osteoporosis, and a preparation method thereof. The complex prescription of the traditional Chinese medicine is composed of epimedium brevicornum maxim and ligustrum lucidum ait. Animal experiments demonstrate that the small complex prescription of the traditional Chinese medicine can effectively reduce the content of serum tartrate-resistant acid phosphatase and alkaline phosphatase, increase serum osteocalcin and the calcium content of bone tissues, and effectively improve pathological changes of the bone tissues, in a hormone-intervened wistar osteoporosis model. The small complex prescription of the traditional Chinese medicine is based on neutrally supplementing yin and yang in kidney with tonifying kidney and strengthening bones as treatment principles, can effectively prevent and alleviate adverse effects of osteoporosis caused by taking glucocorticoids for a long time, provide effective preparations for preventing and treating osteoporosis to other varieties of patients suffering from osteoporosis, and has good development and application prospects.

Description

Technical field: [0001] The invention belongs to the technical field of medicines, and in particular relates to a traditional Chinese medicine compound for preventing and treating glucocorticoid-induced osteoporosis and a preparation method thereof. Background technique: [0002] Due to its important and effective immunosuppressive and anti-inflammatory effects, glucocorticoids (glucocorticoid, GC) are widely used in anti-transplant immune rejection, autoimmune diseases, infection and tumor treatment and other fields. However, more than 50% of patients who receive GC treatment for a long time will experience bone loss, which is the main cause of secondary osteoporosis and iatrogenic osteoporosis, and its incidence rate is about 30%-50%, and The higher the dose of GC and the longer the course of treatment, the higher the incidence of spontaneous fracture. Therefore, the effective prevention and treatment of this iatrogenic bone disease is an important problem to be solved ur...

Claims

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Application Information

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IPC IPC(8): A61K36/638A61P19/10
Inventor 刘仁慧王秀娟许利平
Owner CAPITAL UNIVERSITY OF MEDICAL SCIENCES
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