Hydrogel applicable to angiostomy and preparation method thereof
A hydrogel and anastomosis technology, applied in the field of hydrogel containing poloxamer and hydroxyethyl starch and its preparation, to achieve the effects of high cost performance, increased sealing performance, and improved quality
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Embodiment 1
[0022] Example 1. Preparation of Hydrogel Containing Poloxamer 338 and Hetastarch 40
[0023] In this example, poloxamer 338 and hydroxyethyl starch 40 were selected as raw materials, and organic weak acid citric acid was added to prepare a hydrogel containing poloxamer and hydroxyethyl starch.
[0024] Preparation of hydrogel containing poloxamer 338 and hydroxyethyl starch 40: Weigh 0.01 g of hydroxyethyl starch 40, disperse it in 10 ml of water for injection, dissolve it in a water bath at 30 ° C, add 3.0 g of poloxamer 338 and Shake or stir 0.01 g of citric acid in a water bath at 20°C until completely dissolved to form a hydrogel, freeze-dry to obtain a freeze-dried powder, fill in sterile vials, and seal. Before use, add 10ml of water for injection and shake slightly to form a hydrogel.
Embodiment 2
[0025] Example 2, Preparation of Hydrogel Containing Poloxamer 188 and Hetastarch 130 / 0.4
[0026] In this example, poloxamer 188 and hydroxyethyl starch 130 / 0.4 were selected as raw materials, and glycine was added to prepare a hydrogel containing poloxamer and hydroxyethyl starch.
[0027] Preparation of hydrogel containing poloxamer 188 and hydroxyethyl starch 130 / 0.4: Weigh 0.025g of hydroxyethyl starch 130 / 0.4 and disperse it in 10ml of water for injection, dissolve it in a water bath at 30°C, add 2.5g of polox Sharm 188 and 0.2g glycine were shaken or stirred in a water bath at 20°C until completely dissolved to form a hydrogel, filled into a sterile syringe, and sealed.
Embodiment 3
[0028] Example 3, Preparation of Hydrogel Containing Poloxamer 407 and Hetastarch 130 / 0.4
[0029] In this example, poloxamer 407 and hydroxyethyl starch 130 / 0.4 were selected as raw materials, and an anticoagulant heparin was added to prepare a hydrogel containing poloxamer and hydroxyethyl starch.
[0030] Preparation of hydrogel containing poloxamer 407 and hydroxyethyl starch 130 / 0.4: Weigh 0.1g of hydroxyethyl starch 130 / 0.4 and disperse it in 10ml of water for injection, dissolve it in a water bath at 30°C, add 1.6g of polox Sharm 407, 0.02ml of vascular endothelial growth factor (VEGF), 0.02ml of heparin (5000 units / ml), shake or stir in a water bath at 20°C until completely dissolved to form a hydrogel, fill in a sterile syringe, seal.
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