Preparation method of niacin sevelamer

A technology of nicotinic acid and nicotinic acid, which is applied in the field of preparation of nicotinic acid sevelamer, can solve the problems of vitamin deficiency, large dosage, undisclosed preparation method of nicotinic acid sevelamer, etc. The method is simple and the effect of taking medicine is convenient

Inactive Publication Date: 2015-02-25
NEW FOUNDER HLDG DEV LLC +2
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

These sevelamer salts have a common shortcoming: the dosage is large, and the daily dosage will reach 2-3g. Due to the large dosage, it will often cause symptoms such as constipation and vitamin deficiency in the user.
[0008] However, there is no disclosure about the above preparation method of nicotinic acid sevelamer in the prior art, therefore, the present invention provides the above preparation method of this nicotinic acid sevelamer

Method used

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  • Preparation method of niacin sevelamer
  • Preparation method of niacin sevelamer
  • Preparation method of niacin sevelamer

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0048] Preparation of basic polyallylamine

[0049] First disperse 80mg of polyallylamine hydrochloride in 500ml pure water, then prepare an aqueous solution of 0.04mg / ml of sodium hydroxide, add 250ml of sodium hydroxide solution to the aqueous dispersion of polyallylamine hydrochloride, and heat up the mixed solution to Stir at 35°C for 30 minutes, filter, collect the filter cake, wash the filter cake 3 times with pure water, and then dry the wet cake obtained after washing at 80°C for 5 hours to obtain basic polyallylamine. Analysis and identification of polyallylamine.

Embodiment 2

[0051] Analysis of Basic Polyallylamine

[0052] Take some samples of the basic polyallylamine prepared in Example 1, disperse them in water, stir, add silver nitrate solution to the dispersion, and no precipitation occurs. It shows that the chloride ions in the basic polyallylamine have been completely removed.

Embodiment 3

[0054] Preparation of Nicotinic Acid Polyallylamine

[0055] Take 10 g of the basic polyallylamine prepared according to the method of Example 1 and disperse it in 50000 ml of pure water, then dissolve 15 g of nicotinic acid in 500 ml of aqueous solution to make a nicotinic acid solution, and add the nicotinic acid solution to the basic polyallylamine The aqueous dispersion of allylamine was stirred at 30° C. for 8 hours, and the obtained reaction product was filtered to collect the filter cake, washed with pure water for 5 times, and freeze-dried.

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Abstract

The invention provides a preparation method of niacin sevelamer. The method comprises steps of: (a) reacting polyallylamine hydrochloride and alkali to obtain alkaline polyallylamine; (b) reacting the alkaline polyallylamine and niacin to obtain niacin polyallylamine; and (c) carrying out a crosslinking reaction for the niacin polyallylamine and a crosslinking agent to obtain the niacin sevelamer. The preparation method is simple, low in product impurities and high in yield.

Description

technical field [0001] The invention relates to the field of biomedicine, in particular to a preparation method of nicotinic acid sevelamer. Background technique [0002] Niacin and its derivatives, such as nicotinic acid esters, can not only reduce the levels of triglycerides, very low-density lipoprotein cholesterol, low-density lipoprotein cholesterol, and lipoproteins in plasma, but also effectively increase the level of high-density lipoprotein cholesterol. Recent studies It was found that niacin and its derivatives can effectively reduce the blood phosphorus level of hemodialysis patients with hyperphosphatemia. [0003] Sevelamer salt is a new generation drug approved by the U.S. Food and Drug Administration. It is mainly used as a phosphorus binder. It is a new drug in pharmacological classification. It is characterized by no aluminum, no calcium, and no Polymers containing any metal components should be taken together with the drug at the same time as the three mea...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): C08G73/04C08J3/24A61K31/785A61P7/00A61P3/06
Inventor 托娅易崇勤王振国任爱国张峰王玉莉
Owner NEW FOUNDER HLDG DEV LLC
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