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Method for detecting heavy metal elements in anti-inflammatory and analgesic bolus by inductively coupled plasma mass spectrometric method

A technique for Pien Tze Huang and heavy metals, which is applied in the detection field of heavy metal elements in Pien Tze Huang by ion mass spectrometry, and can solve the problem that there is no limit for detecting heavy metals in Pien Tze Huang.

Active Publication Date: 2013-04-03
ZHANGZHOU PIEN TZE HUANG PHARM
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

At present, there is no method to detect the limit of heavy metal elements in Pien Tze Huang

Method used

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  • Method for detecting heavy metal elements in anti-inflammatory and analgesic bolus by inductively coupled plasma mass spectrometric method
  • Method for detecting heavy metal elements in anti-inflammatory and analgesic bolus by inductively coupled plasma mass spectrometric method
  • Method for detecting heavy metal elements in anti-inflammatory and analgesic bolus by inductively coupled plasma mass spectrometric method

Examples

Experimental program
Comparison scheme
Effect test

experiment example 1

[0040] Experimental Example 1: Methodological Research

[0041] The mixed standard solution and Pien Tze Huang 1007031 were used as samples to investigate the linearity, detection limit, repeatability, precision, accuracy and recovery of the method.

[0042] 1. Linear relationship and method detection limit experiment

[0043] (1) Instruments and reagents:

[0044] American Agilent7700x inductively coupled plasma mass spectrometer; American Milli-Q ultrapure water system; microwave digestion instrument (Anton-Paar); Mettler electronic analytical balance (XP205).

[0045] Nitric acid (excellent pure); ultrapure water (18.2MΩ / cm ) newly prepared for immediate use; standard solutions of Cr, Cu, Zn, As, Se, Cd, Hg, Pb, internal standard solutions (Li, Sc, Ge ,Y,In,Tb,Bi ), tuning solution ( 59 Co, 89 Y, 205 Tl, 156 CeO / 140 Ce). Pien Tze Huang (Specification: 3g / capsule).

[0046] All glass instruments, containers and Teflon tanks in this experiment were soaked in 10% nit...

Embodiment 1

[0069] The method of embodiment one measures after 5 batches of Pien Tze Huang samples are processed according to the aforementioned samples, and the measurement results are shown in Table 6.

[0070] Table 6 The results of ICP-MS determination of heavy metals Cr, Cu, Zn, As, Se, Cd, Hg, Pb in Pien Tze Huang (ppm)

[0071]

[0072] The following embodiments can all achieve the effects of the above experimental examples.

Embodiment 1

[0074] A. Preparation of standard stock solution: Measure 1ml of mixed standard solution of Cr, Cu, Zn, As, Se, Cd, Pb elements with a concentration of 10ug / ml, dilute with 10% nitric acid solution, and make every 1ml contain Cr, Cu , Zn, As, Se, Cd, Pb 0.001mg of the mixed standard solution, that is; take another 1ml of Hg element standard solution with a concentration of 10ug / ml, dilute it with 10% nitric acid solution, and make it contain 0.001mg of Hg per 1ml The standard solution, namely;

[0075] B. Preparation of standard solution: Measure 0.5ml of Cr, Cu, Zn, As, Se, Cd, Pb standard stock solution with concentration of 1ug / ml and 2ml of mercury standard stock solution of 1ug / ml, dilute with 2% nitric acid solution Make a mixed solution containing 0, 0.000005, 0.00001, 0.00002, 0.00005, 0.0001mg of Cr, Cu, Zn, As, Se, Cd, Pb per 1ml; a series containing 0, 0.000002, 0.000004, 0.00001, 0.00002mg of Hg concentration standard solution;

[0076]C, the preparation of need ...

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Abstract

The invention discloses a method for detecting heavy metal elements in anti-inflammatory and analgesic bolus, and specifically relates to a method for detecting the heavy metal elements in the anti-inflammatory and analgesic bolus by an inductively coupled plasma mass spectrometric method. The detection method provided by the invention comprises the following steps of: preparing a standard storage solution, preparing a standard solution, preparing a test solution and preparing a reagent blank solution; and through the detection by using the method, the content of Cr is 0.0-1.1 ppm, the content of Cu is 9-26 ppm, the content of Zn is 33-118 ppm, the content of As is 0.6-1.2 ppm, the content of Se is 0.1-0.4 ppm, the content of Cd is 0.1-0.2 ppm, the content of Hg is 0.2-0.4 ppm, and the content of Pb is 3.6-9.6 ppm. The method provided by the invention has the advantages that the method is rapid and simple and has higher sensitivity and wider dynamic linear range, a measuring result is exact and reliable, and the method can be used for detecting heavy metal in the anti-inflammatory and analgesic bolus.

Description

technical field [0001] The invention relates to a method for detecting heavy metal elements in Pien Tze Huang, in particular to a method for detecting heavy metal elements in Pien Tze Huang by inductively coupled plasma mass spectrometry. Background technique [0002] Inductively coupled plasma mass spectrometry is the most powerful element detection analysis method. It has the characteristics of less interference, low detection limit, fast analysis speed, wide linearity and simultaneous detection of multiple elements. It is superior to atomic absorption spectrophotometry and inductively coupled plasma spectrometry, and has become an important tool for heavy metal element analysis. The 2010 edition of the Pharmacopoeia of the People's Republic of China only stipulates the limits of heavy metal content in a few medicinal materials. At present, there is no method to detect the limit of heavy metal elements in Pien Tze Huang. Contents of the invention [0003] The invention...

Claims

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Application Information

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IPC IPC(8): G01N27/62G01N27/626
Inventor 潘杰黄进明于娟陈珏
Owner ZHANGZHOU PIEN TZE HUANG PHARM
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