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A traditional Chinese medicine solid particle composition containing zedoary volatile oil and Wuling bacteria powder and its preparation method and preparation

A technology of volatile oil and solid particles of Curcuma radix, applied in the direction of drug combination, medical preparations containing active ingredients, pharmaceutical formulations, etc. Effectiveness, reduced process time, reduced losses

Active Publication Date: 2015-09-16
ZHEJIANG JOLLY PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0011] 2. In the drying process of volatile oil clathrate, some volatile oil escapes and part of it is lost, the retention of volatile oil decreases, and it causes certain working environment pollution, and the operator feels uncomfortable;
[0012] 3. If further processing, granulation, granule drying and other processes are made into solid preparations such as tablets and capsules, the retention of volatile oil in these solid preparations will be further reduced to only about 50%, which will affect the effectiveness and quality of the drug

Method used

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  • A traditional Chinese medicine solid particle composition containing zedoary volatile oil and Wuling bacteria powder and its preparation method and preparation

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Experimental program
Comparison scheme
Effect test

Embodiment 1

[0053] The weight ratio of the composition of the present embodiment is: turmeric oil 2.5%, Wuling powder 32%, dry extract 32%, and other auxiliary materials 29.5%.

[0054] The preparation method of the film-coated tablet containing zedoary oil, the method comprises the following steps:

[0055] 1) Extract zedoary into volatile oil, and make dry extract from zedoary residue, fritillary fritillary and Alisma;

[0056] 2) Inclusion of volatile oil: take β-cyclodextrin to prepare a saturated aqueous solution, dissolve zedoary oil in 50% ethanol with the same weight ratio, and add it to the saturated aqueous solution according to the ratio of zedoary oil: β-cyclodextrin = 1:6, Stir at room temperature for 3 hours at a stirring speed of 100 rpm, let stand overnight, remove the supernatant, vacuum filter the lower precipitate, and set aside;

[0057] 3) Put the wet zedoary oil inclusion compound and Wuling bacteria powder on the rotary granulator for pre-mixing and granulation;

...

Embodiment 2

[0063] The weight ratio of the composition of the present embodiment is: zedoary oil 3.5%, Wuling powder 35%, dry extract 28%, and other auxiliary materials 33.5%.

[0064] The preparation method of the granule containing zedoary oil, the method comprises the following steps:

[0065] 1) Extract zedoary into volatile oil, and make dry extract from zedoary residue, fritillary fritillary and Alisma;

[0066] 2) Inclusion of volatile oil: take β-cyclodextrin to prepare a saturated aqueous solution, dissolve zedoary oil in 50% ethanol with the same weight ratio, and add it to the saturated aqueous solution according to the ratio of zedoary oil: β-cyclodextrin = 1:6, Stir at room temperature for 3 hours at a stirring speed of 100 rpm, let stand overnight, remove the supernatant, vacuum filter the lower precipitate, and set aside;

[0067] 3) Put the wet zedoary oil inclusion compound and Wuling bacteria powder on the rotary granulator for pre-mixing and granulation;

[0068] 4) M...

Embodiment 3

[0072] The weight ratio of the composition of this embodiment is: Zedoary oil 6.0%, Wuling powder 40%, dry extract 36%, and other auxiliary materials 18.0%.

[0073] The preparation method of the capsule containing zedoary oil, the method comprises the following steps:

[0074] 1) Extract zedoary into volatile oil, and make dry extract from zedoary residue, fritillary fritillary and Alisma;

[0075] 2) Inclusion of volatile oil: take β-cyclodextrin to prepare a saturated aqueous solution, dissolve zedoary oil in 50% ethanol with the same weight ratio, and add it to the saturated aqueous solution according to the ratio of zedoary oil: β-cyclodextrin = 1:6, Stir at room temperature for 3 hours at a stirring speed of 100 rpm, let stand overnight, remove the supernatant, vacuum filter the lower precipitate, and set aside;

[0076] 3) Put the wet zedoary oil inclusion compound and Wuling bacteria powder on the rotary granulator for pre-mixing and granulation;

[0077] 4) Mix the ...

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Abstract

The invention relates to a traditional Chinese medicine solid granule composition containing curcuma zedoary volatile oil and Wuling mycelia powder, a preparation method thereof and preparation. The traditional Chinese medicine solid granule composition is prepared by mixing and pelletizing the following components in percentage by weight: 2-10 percent of curcuma zedoary volatile oil, 10-40 percent of Wuling mycelia powder, 10-40 percent of dry extract prepared by curcuma zedoary residues, thunberg fritillary bulb and rhizoma alismatis and 10-75 percent of other preparation accessories, wherein the curcuma zedoary volatile oil is included with beta-cyclodextrin by adopting the saturated water solution method; solid and liquid in an inclusion compound are separated from each other; and the inclusion compound is pelletized after being mixed with the Wuling mycelia powder, then is prepared to the traditional Chinese medicine granule composition. The composition, the method and the preparation have the advantages of removing the drying procedure, reducing the loss of the volatile oil, largely shortening the technique time, improving the retention rate of the curcuma zedoary volatile oil in preparation finished products and guaranteeing the quality and the effectiveness of drugs.

Description

technical field [0001] The invention relates to the field of traditional Chinese medicine preparations, in particular to a traditional Chinese medicine solid particle composition containing zedoary zedoary volatile oil and Wuling bacteria powder, a preparation method and a preparation thereof. Background technique [0002] The application of volatile oils of traditional Chinese medicines has a long history, and the effectiveness of many volatile oils of traditional Chinese medicines has been known to the ancients. According to the chemical research of modern Chinese medicine, there are a large number of Chinese medicinal materials containing volatile oil, involving almost all types of traditional Chinese medicine, such as mint, Bupleurum, Huoxiang, Curcuma, Chuanqiong, Perilla volatile oil, etc. The properties of the volatile oils of traditional Chinese medicines vary greatly. They are liquid at room temperature, relatively volatile, and unstable in nature. At present, soft...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K36/9066A61K9/28A61K9/48A61K9/16A61P13/08
Inventor 陈建朱方剑潘旖逯振宇刘华本彭晓国林丽萍姚炳兴
Owner ZHEJIANG JOLLY PHARMA