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Neural electrode interface modification material as well as neural electrode and preparation method of neural electrode

A technology for electrode interface and modified materials, which is applied in electrodes, internal electrodes, medical science, etc., can solve the problems of neuron damage, affect the performance of nerve electrodes, and fail to meet long-term implantation, so as to improve biocompatibility and improve durability. sexual effect

Active Publication Date: 2013-05-08
SHENZHEN INST OF ADVANCED TECH CHINESE ACAD OF SCI
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

Microglia are then activated, and then secrete reactive oxygen species and inflammatory cytokines, some of which are toxic, so their adjacent neurons may be damaged, which seriously affects the performance of nerve electrodes and cannot meet the purpose of long-term implantation

Method used

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  • Neural electrode interface modification material as well as neural electrode and preparation method of neural electrode
  • Neural electrode interface modification material as well as neural electrode and preparation method of neural electrode
  • Neural electrode interface modification material as well as neural electrode and preparation method of neural electrode

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preparation example Construction

[0049] see figure 2 , the preparation method of the neural electrode of an embodiment, comprises the following steps:

[0050] Step S110: performing hydrophilic treatment on the surface of the nerve electrode body, and introducing hydrophilic groups into the surface of the nerve electrode body.

[0051] The non-functional area of ​​the nerve electrode body is formed of materials such as silicone rubber, polyimide, or silicon dioxide. Due to the strong hydrophobicity of silicone rubber, polyimide and other materials, in order to subsequently form an interface modification layer closely combined with the nerve electrode body, the surface of the nerve body is firstly treated with hydrophilicity to improve the hydrophilicity of the nerve body surface.

[0052] In this embodiment, the nerve electrode body is subjected to plasma treatment for 30 to 120 seconds under glow discharge conditions, and hydrophilic groups are introduced into the surface of the nerve electrode body, and t...

Embodiment 1

[0076] Preparation of neural electrodes

[0077] 1. The nerve electrode body is subjected to plasma treatment under glow discharge conditions for 30 seconds, and hydrophilic groups are introduced into the surface of the nerve electrode body, and the hydrophilic groups are distributed on the surface of the non-functional area and the functional area of ​​the nerve electrode body;

[0078] 2. Mix acrylic acid monomer and polyvinyl alcohol aqueous solution (the mass fraction of polyvinyl alcohol is 2%), wherein the molar ratio of acrylic acid monomer and polyvinyl alcohol repeating segment is 3:2. Acrylic acid is polymerized in the mixed solution to form polyacrylic acid, and forms polyacrylic acid-polyvinyl alcohol cross-linked polymer with polyvinyl alcohol to obtain a water-containing gel polymer, wherein the mass ratio of polyacrylic acid to polyvinyl alcohol is 27: 11. Coating the above-mentioned hydrogel polymer on the surface of the nerve electrode body with hydrophilic g...

Embodiment 2

[0087] Preparation of neural electrodes

[0088] 1. The nerve electrode body is subjected to plasma treatment under glow discharge conditions for 120 seconds, and hydrophilic groups are introduced into the surface of the nerve electrode body, and the hydrophilic groups are distributed on the surface of the non-functional area and the functional area of ​​the nerve electrode body;

[0089] 2. Mix acrylic acid monomer and polyvinyl alcohol aqueous solution (the mass fraction of polyvinyl alcohol is 5%), wherein the molar ratio of acrylic acid monomer and polyvinyl alcohol repeating segment is 2:3. Acrylic acid is polymerized in the mixed solution to form polyacrylic acid, and forms polyacrylic acid-polyvinyl alcohol cross-linked polymer with polyvinyl alcohol to obtain a water-containing gel polymer, wherein the mass ratio of polyacrylic acid to polyvinyl alcohol is 12: 11. Coating the above-mentioned hydrogel polymer on the surface of the nerve electrode body with hydrophilic ...

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Abstract

The invention relates to a neural electrode interface modification material, a neural electrode and a preparation method of the neural electrode. The neural electrode interface modification material comprises a gel polymer, a conducting polymer, a bioactive substance and an anti-inflammatory drug, wherein the gel polymer is a cross-linked polymer which is formed from polyacrylic acid and polyvinyl alcohol; a cross-linked network is formed by the conducting polymer and the cross-linked polymer; and the bioactive substance and the anti-inflammatory drug are inserted in the cross-linked network. The high-molecular polymer which is high in biocompatibility and stability is composed of the gel polymer, the conducting polymer, the bioactive substance and the anti-inflammatory drug, and the neutral electrode interface modifying a neural prosthesis through the neural electrode interface modification material can enhance durable biocompatibility of the neural electrode.

Description

technical field [0001] The invention relates to the technical field of medical materials, in particular to a nerve electrode interface modification material, a nerve electrode and a preparation method of the nerve electrode. Background technique [0002] With the continuous acceleration of the pace of life, people's body and mind are often in a state of high tension, which makes depression, epilepsy and other neurological diseases significantly increase. At the same time, as the global population gradually transitions to aging, neurodegenerative diseases are gradually increasing and becoming a major social burden. [0003] The development of implantable electrical nerve stimulation therapy (neural modulation) and the emergence of neural prostheses (neural prostheses) have brought hope to a large number of patients. Implantable nerve electrical stimulation therapy is a treatment method that regulates nerves without destroying nerve tissue, and it can treat or partially resto...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L27/34A61L27/54A61N1/05
Inventor 鲁艺王立平钟成张元元屠洁杨帆
Owner SHENZHEN INST OF ADVANCED TECH CHINESE ACAD OF SCI
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