Preparation method of soybean isoflavone-chitosan slow-release microcapsules

A technology of soybean isoflavones and chitosan, which is applied in the directions of non-active ingredients medical preparations, medical preparations containing active ingredients, pharmaceutical formulas, etc., can solve the problems of low absorption rate, complicated operation, limited effect, etc. The effect of stable quality, uniform particles and high production efficiency

Active Publication Date: 2013-05-15
ZHEJIANG CHINESE MEDICAL UNIVERSITY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Although there are many commercially available SI soft capsules, the actual effect is limited. This is mainly because SI is a fat-soluble drug with low absorption rate in the body, low blood drug concentration, and fast metabolic degradation, resulting in insignificant drug effects. This largely limits the application of SI
[0003] In recent years, chitosan has been widely used as a controlled and sustained release material in oral drug delivery systems. Soy isoflavone sustained release microcapsules have bee

Method used

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  • Preparation method of soybean isoflavone-chitosan slow-release microcapsules
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  • Preparation method of soybean isoflavone-chitosan slow-release microcapsules

Examples

Experimental program
Comparison scheme
Effect test

Example Embodiment

[0023] The preparation method of soybean isoflavone-chitosan sustained-release microcapsules includes the following steps:

[0024] 1) Prepare liquid A, which is a calcium chloride chitosan gel containing acetic acid, calcium chloride, and chitosan. When preparing, fully dissolve calcium chloride, chitosan, and acetic acid in distilled water in sequence;

[0025] 2) Prepare liquid B, mix the mixed sol with the mass concentration of 1%-3% sodium alginate and the mass-volume concentration of 10mg / ml-40mg / ml soy isoflavones, and stir the mixed sol with a stirrer to make the mixed sol uniformly dispersed Get B solution;

[0026] 3) Gelation reaction, drop B liquid into A liquid by centrifugal granulation method, trigger the gelation reaction of B liquid, and produce soybean isoflavone-chitosan sustained-release microcapsules.

Example Embodiment

[0027] Example one:

[0028] 1. Prepare liquid A: first pour 2L of distilled water into a large beaker, and use a magnetic stirrer to fully dissolve in 2L in the order of anhydrous calcium chloride (20g), chitosan (10g), and acetic acid (20mL). Distilled water (fully dissolve calcium chloride first, then add chitosan to fully dissolve).

[0029] 2. Preparation of liquid B: first take 2L of distilled water and pour it into a large beaker, then weigh 30g of sodium alginate and dissolve it in 2L of distilled water. The dissolution process needs to be heated in a water bath, and the temperature is controlled within the range of 60℃~70℃. During the heating process, fully stir and emulsify until there are no granular particles or bubbles in the solution; Measure 500mL of sodium alginate solution into the beaker, add the weighed 15g Soy isoflavones, stir evenly with a glass rod until there are no small drug particles in the solution (to prevent the particles from clogging the granulator)...

Example Embodiment

[0035] Embodiment two:

[0036] The difference from Example 1 is that when preparing solution B, the concentration of sodium alginate selected is 1.00%: the relative yield of the obtained soybean isoflavone-chitosan sustained-release microcapsules is 79.5%, and the encapsulation rate is 62.5%. , The drug loading is 23.6%.

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Abstract

The invention provides a preparation method of soybean isoflavone-chitosan slow-release microcapsules and relates to a method for preparing slow-release microcapsules. At present, microcapsule drug loading capacity and encapsulation efficiency are low, a pharmacodynamic effect of soybean isoflavone is influenced, operation is complex, controllability is poor, and mass production can not be achieved. The preparation method comprises the following steps of: preparing a solution A, wherein the solution A is calcium chloride chitosan gel containing acetic acid, calcium chloride and chitosan; preparing a solution B, namely uniformly dispersing a mixed sol solution containing sodium alginate with the mass concentration of 1-2% and soybean isoflavone with the mass-volume concentration of 10-40mg/ml by stirring by a stirrer, so as to obtain the solution B; and carrying out a gelation reaction, namely dropping the solution B into the solution A in a centrifugal pelletizing manner to initiate the gelation reaction, so as to generate the microcapsules. By adopting the preparation method provided by the invention, production efficiency is high; quality is stable, particles are uniform, and relative productivity is high; drug loading capacity is above 30%; encapsulation efficiency is more than 60%; and accumulation release rate for 4 hours is less than 40%.

Description

technical field [0001] The invention relates to a method for preparing sustained-release microcapsules. Background technique [0002] Humans have been eating soybeans for thousands of years. Soy isoflavone (Soy Isoflavone, SI) is a biologically active substance extracted from the natural plant soybean. A large number of experiments and clinical studies at home and abroad have found that SI has a wide range of pharmacological effects such as regulating blood lipids, preventing and treating cancer, anti-aging, improving women's climacteric syndrome, and improving osteoporosis. Cholesterol (TC), total triglycerides (TG), low-density lipoprotein cholesterol (LDL-C), and increase high-density lipoprotein cholesterol (HDL-C), have the effects of regulating blood lipids and anti-atherosclerosis. Although there are many commercially available SI soft capsules, the actual effect is limited. This is mainly because SI is a fat-soluble drug with low absorption rate in the body, low blo...

Claims

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Application Information

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IPC IPC(8): A61K9/52A61K31/352A61K47/36A61P3/06A61P9/10
Inventor 窦晓兵胡林峰高佳陈宣光
Owner ZHEJIANG CHINESE MEDICAL UNIVERSITY
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