Preparation method of soybean isoflavone-chitosan slow-release microcapsules

Abstract

The invention provides a preparation method of soybean isoflavone-chitosan slow-release microcapsules and relates to a method for preparing slow-release microcapsules. At present, microcapsule drug loading capacity and encapsulation efficiency are low, a pharmacodynamic effect of soybean isoflavone is influenced, operation is complex, controllability is poor, and mass production can not be achieved. The preparation method comprises the following steps of: preparing a solution A, wherein the solution A is calcium chloride chitosan gel containing acetic acid, calcium chloride and chitosan; preparing a solution B, namely uniformly dispersing a mixed sol solution containing sodium alginate with the mass concentration of 1-2% and soybean isoflavone with the mass-volume concentration of 10-40mg / ml by stirring by a stirrer, so as to obtain the solution B; and carrying out a gelation reaction, namely dropping the solution B into the solution A in a centrifugal pelletizing manner to initiate the gelation reaction, so as to generate the microcapsules. By adopting the preparation method provided by the invention, production efficiency is high; quality is stable, particles are uniform, and relative productivity is high; drug loading capacity is above 30%; encapsulation efficiency is more than 60%; and accumulation release rate for 4 hours is less than 40%.

Description

technical field [0001] The invention relates to a method for preparing sustained-release microcapsules. Background technique [0002] Humans have been eating soybeans for thousands of years. Soy isoflavone (Soy Isoflavone, SI) is a biologically active substance extracted from the natural plant soybean. A large number of experiments and clinical studies at home and abroad have found that SI has a wide range of pharmacological effects such as regulating blood lipids, preventing and treating cancer, anti-aging, improving women's climacteric syndrome, and improving osteoporosis. Cholesterol (TC), total triglycerides (TG), low-density lipoprotein cholesterol (LDL-C), and increase high-density lipoprotein cholesterol (HDL-C), have the effects of regulating blood lipids and anti-atherosclerosis. Although there are many commercially available SI soft capsules, the actual effect is limited. This is mainly because SI is a fat-soluble drug with low absorption rate in the body, low blo...

AI Technical Summary

Problems solved by technology

Although there are many commercially available SI soft capsules, the actual effect is limited. This is mainly because SI is a fat-soluble drug with low absorption rate in the body, low blood drug concentration, and fast metabolic degradation, resulting in insignificant drug effects. This largely limits the application of SI

[0003] In recent years, chitosan has been widely used as a controlled and sustained release material in oral drug delivery systems. Soy isoflavone sustained release microcapsules have been prepared using chitosan, sodium alginate or other materials alone as wall materials at home and abroad. However, due to the shortcomings of microcapsule drug loading and low encapsulation efficiency, it affects the pharmacodynamic effect of soybean isoflavones.

Moreover, the traditional preparation process is complex in operation, poor in controllability, and cannot be automated and industrialized on a large scale. Therefore, there is no soy isoflavone sustained-release preparation on the market at present.

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