Preparation method of soybean isoflavone-chitosan slow-release microcapsules
A technology of soybean isoflavones and chitosan, which is applied in the directions of non-active ingredients medical preparations, medical preparations containing active ingredients, pharmaceutical formulas, etc., can solve the problems of low absorption rate, complicated operation, limited effect, etc. The effect of stable quality, uniform particles and high production efficiency
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[0023] The preparation method of soybean isoflavone-chitosan sustained-release microcapsules includes the following steps:
[0024] 1) Prepare liquid A, which is a calcium chloride chitosan gel containing acetic acid, calcium chloride, and chitosan. When preparing, fully dissolve calcium chloride, chitosan, and acetic acid in distilled water in sequence;
[0025] 2) Prepare liquid B, mix the mixed sol with the mass concentration of 1%-3% sodium alginate and the mass-volume concentration of 10mg / ml-40mg / ml soy isoflavones, and stir the mixed sol with a stirrer to make the mixed sol uniformly dispersed Get B solution;
[0026] 3) Gelation reaction, drop B liquid into A liquid by centrifugal granulation method, trigger the gelation reaction of B liquid, and produce soybean isoflavone-chitosan sustained-release microcapsules.
Example Embodiment
[0027] Example one:
[0028] 1. Prepare liquid A: first pour 2L of distilled water into a large beaker, and use a magnetic stirrer to fully dissolve in 2L in the order of anhydrous calcium chloride (20g), chitosan (10g), and acetic acid (20mL). Distilled water (fully dissolve calcium chloride first, then add chitosan to fully dissolve).
[0029] 2. Preparation of liquid B: first take 2L of distilled water and pour it into a large beaker, then weigh 30g of sodium alginate and dissolve it in 2L of distilled water. The dissolution process needs to be heated in a water bath, and the temperature is controlled within the range of 60℃~70℃. During the heating process, fully stir and emulsify until there are no granular particles or bubbles in the solution; Measure 500mL of sodium alginate solution into the beaker, add the weighed 15g Soy isoflavones, stir evenly with a glass rod until there are no small drug particles in the solution (to prevent the particles from clogging the granulator)...
Example Embodiment
[0035] Embodiment two:
[0036] The difference from Example 1 is that when preparing solution B, the concentration of sodium alginate selected is 1.00%: the relative yield of the obtained soybean isoflavone-chitosan sustained-release microcapsules is 79.5%, and the encapsulation rate is 62.5%. , The drug loading is 23.6%.
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