Preparation method for electrondrawing group containing semi-cyanine temperature-sensitive molecular optical probe

A technology of electron-withdrawing groups and optical probes, which is applied in the field of preparation of temperature-sensitive molecular optical probes containing electron-withdrawing groups hemicyanine, can solve problems such as limited applications, and achieve rapid measurement and monitoring effects
CN103113282AInactive Publication Date: 2013-05-22TIANJIN UNIVERSITY OF TECHNOLOGY
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Patent Information

Authority / Receiving Office
CN · China
Current Assignee / Owner
TIANJIN UNIVERSITY OF TECHNOLOGY
Publication Date
2013-05-22
Estimated Expiration
Not applicable · inactive patent

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Abstract

The invention relates to a preparation method for an electrondrawing group containing semi-cyanine temperature-sensitive molecular optical probe. The preparation method comprises the following steps of: 1) mixing iodate of a raw material indoline derivative and aromatic aldehyde by molar ratio of 1:1, and performing reflux in ethanol for 10-15 hours; 2) adding KBF4 and performing reflux for 2 hours for anion exchange; and 3) obtaining the semi-cyanine temperature-sensitive molecular optical probe through recrystallization of absolute ethyl alcohol. The preparation method provided by the invention has the advantages that the electrondrawing group containing semi-cyanine temperature-sensitive molecular optical probe material can quickly determine and monitor temperature of a fluid industrial production line by arranging ultraviolet absorption or fluorescence emission spectrum detection monitoring points; and through fluorescence labeling of living animals by the electrondrawing group containing semi-cyanine temperature-sensitive molecular optical probe, image detection for body temperature of the living animals can be realized through fluorescence imaging technology, so that the electrondrawing group containing semi-cyanine temperature-sensitive molecular optical probe can be applied to fields of biomedical diagnosis and the like.
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Description

【Technical field】

[0001] The invention relates to the preparation of a temperature-sensitive molecular optical probe in optical sensing and detection technology, in particular to a preparation method of a semicyanine temperature-sensitive molecular optical probe containing an electron-withdrawing group. 【Background technique】

[0002] Temperature is an important parameter to describe the basic properties of substances. In many scientific researches and industrial productions, it is necessary to accurately measure the temperature of the acting object. In industrial production, in order to optimize the production process, reduce by-products and energy consumption, real-time temperature measurement is of great significance. The common temperature measurement method is to use contact thermometers, such thermometers include mercury thermometers, thermocouples, thermistors, thermal resistance temperature detectors, etc. With the exception of liquid-scale thermometers such as merc...

Claims

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