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Organic/inorganic hybrid random copolymer, and preparation method and application thereof

A random copolymer, inorganic technology, applied in the field of copolymers

Active Publication Date: 2014-07-30
XIAMEN WAEXIM RUBBER CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

There are even fewer reports on the preparation of temperature / pH dual-sensitive organic / inorganic hybrid random copolymer micelles by copolymerizing inorganic monomers with temperature-sensitive monomers and sensitive monomers.

Method used

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  • Organic/inorganic hybrid random copolymer, and preparation method and application thereof
  • Organic/inorganic hybrid random copolymer, and preparation method and application thereof
  • Organic/inorganic hybrid random copolymer, and preparation method and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0034] 1 random copolymer (MAPOSS 6 -co-NIPAM 100 -co-OEGMA 20 -co-2VP 10 ) preparation

[0035]MAPOSS (0.2849g, 0.3mmol), CDB (0.0136g, 0.05mmol), NIPAM (0.5651g, 5mmol), OEGMA (0.44mL, 1mol), 2VP (0.11mL, 0.5mol) and AIBN (0.00164g, 0.01 mmol) was dissolved in tetrahydrofuran (2mL), and polymerized at 65°C under the protection of argon after continuous freeze-thaw degassing for 3 to 5 times. After 48 hours of reaction, the reaction was quenched with liquid nitrogen to stop the reaction. Using n-hexane as the precipitating agent, the precipitation was repeated three times to obtain an organic-inorganic hybrid random copolymer (MAPOSS) with a molecular weight Mn of 7118 g / mol 6 -co-NIPAM 100 -co-OEGMA 20 -co-2VP 10 ).

[0036] 2 Preparation of organic-inorganic hybrid copolymer micelles

[0037] Dissolve the copolymer (5mg) in 1mLTHF in a graduated test tube, slowly drop 2mL of water into the solution at a rate of 0.5mL / min, and then leave it open at room temperature ...

Embodiment 2

[0044] 1 random copolymer (MAPOSS 6 -co-NIPAM 100 -co-OEGMA 20 -co-2VP 10 ) preparation

[0045] MAPOSS (0.2849g, 0.3mmol), CDB (0.0136g, 0.05mmol), NIPAM (0.5651g, 5mmol), OEGMA (0.44mL, 1mol), 2VP (0.11mL, 0.5mol) and AIBN (0.00164g, 0.01 mmol) was dissolved in tetrahydrofuran (2mL), and polymerized at 65°C under the protection of argon after continuous freeze-thaw degassing for 3 to 5 times. After 24 hours of reaction, the reaction was quenched with liquid nitrogen to stop the reaction. Using n-hexane as the precipitating agent, the precipitation was repeated three times to obtain an organic-inorganic hybrid random copolymer (MAPOSS) with a molecular weight Mn of 5636 g / mol. 6 -co-NIPAM 100 -co-OEGMA 20 -co-2VP 10 ).

[0046] 2 Preparation of organic-inorganic hybrid copolymer micelles

[0047] Dissolve the copolymer (5mg) in 1mLTHF in a graduated test tube, slowly drop 2mL of water into the solution at a rate of 0.5mL / min, and then leave it open at room temperatur...

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Abstract

An organic / inorganic hybrid random copolymer and its preparation method and application relate to a copolymer. An organic / inorganic hybrid random copolymer with good biocompatibility and high temperature / pH double sensitivity and its preparation method and application are provided. The organic / inorganic hybrid random copolymer is Poly(MAPOSSn-co-NIPAMm-co-OEGMAp-co-2VPq). Dissolve MAPOSS, NIPAM, OEGMA, 2VP, initiator, and chain transfer agent in the Schleck tube, remove oxygen through freezing and thawing cycles, and then react under an inert gas atmosphere. After the reaction, add the solution to the precipitant , to obtain organic / inorganic hybrid random copolymers after drying. The application of the organic / inorganic hybrid random copolymer in the preparation of drug carriers, biosensors, micelles for targeted therapy and the like.

Description

technical field [0001] The invention relates to a copolymer, in particular to an organic / inorganic hybrid random copolymer with good biocompatibility and high temperature / pH double sensitivity and its preparation method and application. Background technique [0002] With the rapid development of life science and polymer material science, the research and application of environment-sensitive polymer materials in intelligent drug controlled release system plays an important role, and the research on pH- and temperature-sensitive biocompatible polymer materials has attracted much attention. As a drug carrier, the responsive micellar control system exhibits a series of features and advantages that other systems do not have: (1) The hydrophobic core can encapsulate insoluble drugs, and has a large drug loading capacity, which has a controlled release effect on drugs; ( 2) The nanostructure and hydrophilic shell make it enter the tumor tissue due to the EPR effect (nanoscale polym...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): C08F283/06C08F290/06C08F220/54C08F226/06C08F230/08C08F2/38A61K47/32
Inventor 戴李宗许一婷谢剑杰高辉余世荣罗健龙曾碧榕罗伟昂
Owner XIAMEN WAEXIM RUBBER CO LTD