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Medicinal granule for treating bronchial asthma and preparation method thereof

A technology for asthma and bronchial disease, applied in the field of medicine, can solve the problems of forskolin and its derivative monomers that have not yet been developed into medicines, difficult formulations, application limitations, etc., and achieves avoiding complex equipment and high costs, and a simple preparation method. The effect of easy operation and high safety

Inactive Publication Date: 2013-05-29
CHENGDU JIANJIANG PHARMA FACTORY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the water solubility of this drug is very poor, which brings great difficulties to pharmacy, and its application is also subject to corresponding restrictions. So far, it has not been developed into a drug for forskolin and its derivative monomers.
At present, there is no better drug for the treatment of bronchial asthma on the market

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0023] Weigh the raw materials according to the following proportions: 0.1 kg of Coleus sage, 0.1 kg of Radix Peucedanum, 0.025 kg of Radix Glycyrrhizae, 0.25 kg of Pinellia Rhizoma, and mix them with 90% ethanol for reflux extraction. After recovering the ethanol, 0.15 kg of extract is obtained. Add 0.15 kg of soluble starch in the ratio of 1:1 to soluble starch, then add 0.45 kg of sweetener white sugar according to the ratio of extract; After powdering, pass through a 10-mesh sieve.

Embodiment 2

[0025] Weigh the raw materials according to the following proportions: 1.0 kg of Coleus sativa, 1.0 kg of Radix Peucedanum, 0.25 kg of Radix Glycyrrhizae, and 3.2 kg of Pinellia Rhizome are mixed, refluxed and extracted with 90% ethanol, and 1.0 kg of extract is obtained after recovering ethanol, according to the extract: Add 1 kg of soluble starch in the ratio of 1:1 to soluble starch, then add 3 kg of sweetener white sugar according to the ratio of extract: sweetener 1:3, and finally add 0.4 kg of dextrin according to the ratio of extract: dextrin 1:0.4 After powdering, pass through a 10-mesh sieve.

Embodiment 3

[0027] Weigh the raw materials according to the following proportions: 3.0 kg of Coleus sativa, 2.5 kg of Radix Peucedanum, 0.65 kg of Radix Glycyrrhizae, and 5.0 kg of Pinellia Rhizome are mixed, refluxed and extracted with 80% ethanol, and 2.75 kg of extract is obtained after recovering ethanol, according to the extract: Add 2.75 kg of soluble starch in the ratio of 1:1 to soluble starch, then add 5.5 kg of sweetener white sugar according to the ratio of extract: sweetener 1:2, and finally add 1.375 kg of dextrin according to the ratio of extract: dextrin 1:0.5 , After powdering, pass through 10 sieves.

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Abstract

The invention discloses a medicinal granule for treating bronchial asthma and a preparation method thereof. The medicinal granule is prepared from the following components in parts by weight: 100-300 parts of coleus forskohlin, 100-250 parts of peucedanum roots, 25-65 parts of liquorices and 250-500 parts of pinellia ternate. The coleus forskohlin, the peucedanum roots, the liquorices and the pinellia ternate are fluxed and extracted by 80%-90% of ethanol; the ethanol is recycled to obtain extract; soluble starch, sweetening agent and dextrin are added to the extract, milled and sieved to obtain the medicinal granule. According to the medical granule disclosed by the invention, the coleus forskohlin and the pinellia ternate are used as the main materials, and so the medical granule has the effects of clearing away heat, relieving asthma and relieving a cough. Meanwhile, peucedanum root is further added, so that the pesticide effect is strengthened; and finally, the medicines are blended by liquorice.

Description

technical field [0001] The invention relates to the field of medicine, in particular to a granule for treating bronchial asthma and a preparation method thereof. Background technique [0002] Bronchial asthma and bronchitis are common and frequently-occurring diseases, and the long-term progress of drug research in this field is slow. At present, the aminophylline and adrenaline drugs used to treat this disease at home and abroad are all - receptor agonists. The side effects are severe, and heart rate increase, palpitations, and muscle tremors are more common. As the heart is excited, the oxygen consumption of the myocardium increases. If an asthmatic patient has severe hypoxia, a large dose can cause severe arrhythmia; in addition, repeated use of this kind of drug will produce tolerance and reduce the curative effect. [0003] In the early 1970s, forskolin, a Labdane-type diterpene lactone compound, proved through pharmacological studies that it has the functions of stren...

Claims

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Application Information

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IPC IPC(8): A61K36/8888A61P11/06
Inventor 张强
Owner CHENGDU JIANJIANG PHARMA FACTORY
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