Method for preparing polylactic acid porous support material

A technology of porous scaffold and polylactic acid, which is applied in medical science, prosthesis, etc., can solve the problem of small pore size of porous scaffold, and achieve the effect of no residue of impurities, simple process and high porosity

Inactive Publication Date: 2013-06-19
XIAN REJE BIOLOGICAL TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0003] The purpose of the present invention is to overcome the problem that the pore diameter of the porous scaffold prepared by the current thermally induced phase separation method is too small, and to provide a preparation method of a novel polylactic acid porous scaffold material with a wide pore diameter range

Method used

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  • Method for preparing polylactic acid porous support material

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Effect test

Embodiment 1

[0017] Preparation of Polylactic Acid Porous Scaffold

[0018] Dissolve polylactic acid in a mixed solvent of dioxane and water at a temperature of 40°C to 80°C to obtain a polylactic acid solution. The weight volume concentration of the polylactic acid solution is 1% to 10%. The volume ratio of water is 100 / 1 to 80 / 20; inject the above polylactic acid solution into the mold, roughen for 1 to 12 hours, and the roughening temperature is 10°C to 50°C. Freeze for 0.5 to 3 hours at ℃, and then freeze in a freeze dryer to obtain the polylactic acid porous scaffold of the present invention.

Embodiment 2

[0020] Effect of polylactic acid concentration on the performance of porous scaffolds

[0021] Dissolve poly-L-lactic acid in a mixed solvent of dioxane: water (volume ratio 85 / 15) at 80°C, and the weight-volume concentrations of poly-lactic acid are 4%, 5% and 6% (w / v), Pour into a glass mold with a diameter of 1.2cm and a thickness of 8cm, roughen at 25°C for 5 hours, freeze at -20°C for 1 hour, and then freeze-dry in a freeze dryer for 24 hours to obtain a three-dimensional poly-L-lactic acid porous scaffold . The effect of polylactic acid concentration on the pore size and porosity of porous scaffolds is shown in Table 1.

[0022] Table 1 Effect of polylactic acid concentration on the pore size and porosity of porous scaffolds

[0023]

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Abstract

The present invention discloses a method for preparing polylactic acid porous support material. By changing the conditions in the preparation process, such as ratio of dioxane and water, concentration of a polylactic acid solution, coarsening temperature, coarsening time, and the number of the coarsenings, the micromorphological structure of a porous support such as pore size, pore morphology and porosity can be effectively controlled. The pore size of 5-400 microns is controllable, breaking material pore size ceiling of 200 microns by the conventional thermally induced phase separation. The method has a very important significance for the preparation of porous tissue engineering materials.

Description

technical field [0001] The invention belongs to the technical field of tissue engineering, and in particular relates to a preparation method of a polylactic acid porous scaffold material for tissue engineering. Background technique [0002] Tissue engineering is a hot spot in life science in the 21st century. Its core content is three-dimensional cell culture in vitro, and its basic method is to form a complex of seed cells and biodegradable biomaterials to replace damaged tissues and organs. Porous polymer tissue engineering materials are widely used in bone, cartilage, skin, liver and other tissue engineering because they can simulate extracellular matrix well. As a porous scaffold for tissue engineering, it needs to have suitable mechanical properties to carry a certain load, have a good biocompatibility interface to help cells adhere and grow smoothly, and have appropriate pore size and porosity and a high degree of interconnected structure so that Cell access to the s...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C08J9/28C08L67/04A61L27/18A61L27/56
Inventor 陈富林
Owner XIAN REJE BIOLOGICAL TECH
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