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Integrated ultrasonic cyclic extracting and separating technology for cistanche functional ingredient

A technology of ultrasonic circulation extraction and functional components, which is applied in the direction of medical preparations containing active ingredients, organic active ingredients, plant/algae/fungus/moss components, etc., can solve the problem of resource waste of Cistanche deserticola, shorten the extraction time, improve Extraction efficiency, the effect of increasing the strength of the ultrasonic field

Active Publication Date: 2013-07-10
内蒙古宏魁生物药业有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

At present, in the extraction of Cistanche deserticola, the extraction method of a certain type or a certain main active ingredient such as phenylethanol glycosides, polysaccharides, and galactitol is generally studied separately, and a variety of active ingredients are considered comprehensively for integrated extraction. Less research results in a great waste of Cistanche resources

Method used

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  • Integrated ultrasonic cyclic extracting and separating technology for cistanche functional ingredient

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0020] Cistanche powder 1kg, add 20 times the amount of 50% ethanol solution, 60 ℃ cycle ultrasonic extraction for 60 minutes (ultrasonic power is 100W / L, stirring speed is 600r / min, duty ratio is 1:1), filter, and the filtrate is decompressed Concentrate to obtain concentrated solution I and filter residue 400g. Wherein, the concentrated solution I was added to the macroporous adsorption resin HPD-300 column, eluted with deionized water of 4 times the column volume, collected the water eluate for later use, and then eluted with 50% ethanol solution of 3 times the column volume, Collect the fractions containing total glycosides of phenylethyl alcohol, concentrate and freeze-dry to obtain 60 g of total glycosides of phenylethyl alcohol of Cistanche cistanche, wherein the content of total phenylethyl alcohol glycosides is 60%, the content of echinacoside is 13.0%, and the content of verbascoside is 12.9%; the filter residue is dried Then add 30 times the amount of water, 70 ° C ...

Embodiment 2

[0022] Cistanche powder 1kg, add 20 times the amount of 40% ethanol solution, 60 ℃ ultrasonic circulation extraction for 60 minutes (ultrasonic power is 100W / L, stirring speed is 600r / min, duty ratio is 1:1, filter, and the filtrate is concentrated under reduced pressure , to obtain concentrated solution I and filter residue 430g.Wherein, concentrated solution I is added in the macroporous adsorption resin column AB-8, with the deionized water elution of 4 times of column volumes, collects water eluate and retains, and then uses 3 times of column volumes Eluted with 50% ethanol solution by volume, collected the fractions containing total phenylethanol glycosides, concentrated, and freeze-dried to obtain 65 g of total phenylethanol glycosides of Cistanche deserticola, wherein the content of total phenylethanol glycosides was 52%, and the content of echinacoside was 16%. The content of verbascoside is 9%. After the filter residue is dried, add 30 times the amount of water, 70°C f...

Embodiment 3

[0024] Cistanche powder 1kg, add 20 times the amount of 60% ethanol solution, 50 ℃ ultrasonic circulation extraction for 60 minutes (ultrasonic power is 100W / L, stirring speed is 600r / min, duty ratio is 1:1, filter, and the filtrate is concentrated under reduced pressure , to obtain concentrated solution I and filter residue 380g.Wherein, concentrated solution I is added in the macroporous adsorption resin column D101, with the deionized water elution of 4 times of column volumes, collects water eluent and stays for use, then uses 3 times of column volumes Eluted with 50% ethanol solution, collected fractions containing total phenylethanol glycosides, concentrated, and freeze-dried to obtain 55 g of total phenylethanol glycosides of Cistanche deserticola, wherein the content of total phenylethanol glycosides was 66%, the content of echinacoside was 11%, and verbascoside The content is 15%; after the filter residue is dried, add 30 times the amount of water, 70 ° C circular ultr...

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Abstract

The invention relates to an integrated ultrasonic cyclic extracting and separating technology for a cistanche functional ingredient. The integrated ultrasonic cyclic extracting and separating technology is characterized by comprising the step of carrying out integrated extraction and subsequent separation on the main effect ingredients, such as phenylethanoid glycosides, polysaccharide and total oligosaccharide of the cistanche by an ultrasonic reinforced extraction technology. By adopting the technology, the comprehensive utilization problem of the cistanche resource is solved; the cistanche extracting efficiency is improved; the production cost is reduced; and the integrated ultrasonic cyclic extracting and separating technology has good industrial production and market development prospects.

Description

technical field [0001] The invention relates to an integrated ultrasonic circulation extraction and separation process of functional components of Cistanche deserticola, in particular to an integrated extraction and separation process of total phenylethanol glycosides of Cistanche deserticola, total oligosaccharides of Cistanche deserticola and polysaccharides of Cistanche deserticola. Background technique [0002] Cistanche is the scaly dry fleshy stem of Cistanche deserticola, also known as Cistanche deserticola, Da Yun, golden bamboo shoots, and goblin. Cistanche deserticola is a well-known tonifying traditional Chinese medicine, which has the functions of nourishing kidney yang, nourishing essence and blood, moistening intestines and laxative. The most frequently used kidney-yang medicine. Modern pharmacological studies have shown that Cistanche has various functions such as improving sexual function, anti-aging, improving learning and memory, anti-senile dementia, and ...

Claims

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Application Information

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IPC IPC(8): A61K36/64A61K31/715A61K31/702A61K135/00
Inventor 赵兵袁晓凡刘伯言王丽卫赵庆生王晓东
Owner 内蒙古宏魁生物药业有限公司
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